The timing of insulin/c-Ras signal is critical for its effect upon the differentiation of C3H1OT1/2-derived preadipocytes

Cancer Letters

Volumn 115, Issue 2, 1997, Pages 165-171

  Preston, Thomas ^a   Brownell, Heather ^a   Raptis, Leda ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

10T1 2 derived preadipocytes; Adipocytic differentiation; c Ras; Insulin

Indexed keywords

INSULIN; PEPTIDE HORMONE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL ONCOGENE; CONTROLLED STUDY; DOWN REGULATION; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROADIPOCYTE; SIGNAL TRANSDUCTION; TIME;

ADIPOCYTES; ANIMALS; DOWN-REGULATION; GENE EXPRESSION REGULATION; GENES, RAS; INSULIN; MICE; MICE, INBRED C3H; RAS PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030897675     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)04724-1     Document Type: Article

References (27)

1. Anderson, S.K., Stankova, J. and Roder, J.C. (1989) Decreased p21 levels in anti-sense ras transfectants augments NK sensitivity, Mol. Immunol., 26, 985-991.
2. Brownell, H.L., Whitfield, J.F. and Raptis, L. (1996) Cellular Ras partly mediates gap junction closure by the polyoma virus middle Tumor antigen, Cancer Lett., 103, 99-106.
3. ras activation, EMBO J., 10, 1103-1109.
4. Butterwith, S.C. (1994) Molecular events in adipocyte development, Pharmacol. Ther., 61, 399-411.
5. v-src expressed in the yeast Saccharomyces cerevisiae, Mol. Biol. Cell, 5, 283-296.
6. Hu, M.C.T. and Davidson, N. (1990) A combination of derepression of the lac operator-repressor system with positive induction by glucocorticoid and metal ions provides a high-level-inducible gene expression system based on the human metallothionein-IIa promoter, Mol. Cell. Biol., 10, 6141-6151.
7. ras, J. Biol. Chem., 269, 5699-5704.
8. ras and protein kinase C function in distinct and interdependent signaling pathways in C3H 10T1/2 fibroblasts, Mol. Cell. Biol., 13, 1471-1479.
9. Lowy, D.R. and Willumsen, B.M. (1993) Function and regulation of Ras, Annu. Rev. Biochem., 62, 851-891.
10. Lu, Y., Raptis, L., Anderson, S., Corbley, M.J., Zhou, Y.C., Pross, H. and Haliotis, T. (1992) Ras modulates commitment and maturation of 10T1/2 fibroblasts to adipocytes. Biochem. Cell Biol., 70, 1249-1257.
11. Maassen, J.A., Burgering, B.M., Medema, R.H., Osterop, A.P., van der Zon, G.C., Moller, W. and Bos, J.L. (1992) The role of Ras proteins in insulin signal transduction, Horm. Metab. Res., 24, 214-218.
12. ras, Mol. Cell. Biol., 13, 155-162.
13. Mulcahy, L.S., Smith. M.R. and Stacey, D.W. (1985) Requirement for ras protooncogene function during serum-stimulated growth of NIH-3T3 cells, Nature, 313, 241-243.
14. ras by transforming growth factor β in epithelial cells, J Biol. Chem., 267, 5029-5031.
15. Navre, M. and Ringold, G.M. (1989) Differential effects of fibroblast growth factor and tumor promoters on the initiation and maintenance of adipocyte differentiation, J. Cell Biol., 109, 1857-1863.
16. Porras, A., Nebreda, A.R., Benito, M. and Santos, E. (1992) Activation of Ras by insulin in 3T3 L1 cells does not involve GTPase-activating protein phosphorylation, J. Biol. Chem., 267, 21124-21131.
17. Raptis, L. and Bolen, J.B. (1989) Polyomavirus transforms rat F111 and mouse NIH 3T3 cells by different mechanisms, J. Virol., 63, 753-758.
18. Raptis, L., Lamfrom, H. and Benjamin. T.L. (1985) Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts, Mol. Cell. Biol., 5, 2476-2486.
19. Raptis, L., Marcellus, R.,Corbley, M.J., Krook. A., Whitfield, J., Anderson, S.K. and Haliotis, T. (1991) Cellular ras gene activity is required for full neoplastic transformation by polyomavirus. J. Virol., 65, 5203-5210.
20. Reznikoff, C.A., Brankow, D.W. and Heidelberger, C. (1973) Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res., 33, 3231-3238.
21. Ringold, G.M., Chapman, A.B., Knight, D.M., Navre, M. and Torti, F.M. (1988) Hormonal control of adipocyte differentiation and adipocyte gene expression, Recent Prog. Horm. Res., 44, 115-140.
22. Smith, MR., DeGudicibus, S.J. and Stacey, D.W. (1986) Requirement for c-Ras proteins during viral oncogene transformation, Nature, 320, 540-543.
23. Sparks, R.L., Alien, B.J. and Straus, E.E. (1992) TGFβ blocks early but not late differentiation-specific gene expression and morphologic differentiation of 3T3 preadipocytes, J. Cell. Physiol., 150, 568-577.
24. Stumpo, D.J. and Blackshear, P.J. (1986) Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3 L1fibroblasts and adipocytes, Proc. Nat. Acad. Sci. USA, 83, 9453-9457.
25. Trimble, W.S., Johnson, P.W., Hozumi. N. and Roder, J.C. (1986) Inducible cellular transformation by a metallothionein-ras hybrid oncogene leads to natural killer cell susceptibility, Nature, 321, 782-784.
26. Wagner, R.W. and Nishikura, K. (1988) Cell cycle expression of RNA duplex unwindase activity in mammalian cells, Mol. Cell. Biol., 8, 770-777.
27. Yonezawa, K., Ando, A., Kaburagi, Y., Yamamoto-Honda, R., Kitamura, T., Hara, K., Nakafuku, M., Okabayashi, Y., Kadowaki, T. and Kaziro, Y. et al. (1994) Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors, J. Biol. Chem., 269, 4634-4640.