Transcomplementation of nucleotide priming and reverse transcription between independently expressed TP and RT domains of the hepatitis B virus reverse transcriptase

Journal of Virology

Volumn 71, Issue 4, 1997, Pages 2996-3004

  Lanford, Robert E ^a   Notvall, Lena ^a   Lee, Helen ^a   Beames, Burton ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEOTIDE; NUCLEOTIDE; RNA DIRECTED DNA POLYMERASE;

ARTICLE; BACULOVIRUS; DNA STRAND; DNA VIRUS; HEPATITIS B; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENTIAL ANALYSIS; TRANSCRIPTION INITIATION;

EID: 0030896812     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.4.2996-3004.1997     Document Type: Article

References (56)

1. Ayola, B., P. Kanda, and R. E. Lanford. 1993. High level expression and phosphorylation of hepatitis B virus polymerase in insect cells with recombinant baculoviruses. Virology 194:370-373.
2. Bartenschlager, R., M. Junker-Niepmann, and H. Schaller. 1990. The P gene product of hepatitis B virus is required as a structural component for genomic RNA encapsidation. J. Virol. 64:5324-5332.
3. Bartenschlager, R., and H. Schaller. 1988. The amino-terminal domain of the hepadnaviral P-gene encodes the terminal protein (genome-linked protein) believed to prime reverse transcription. EMBO J. 7:4185-4192.
4. Bartenschlager, R., and H. Schaller. 1992. Hepadnaviral assembly is initiated by polymerase binding to the encapsidation signal in the viral RNA genome. EMBO J. 11:3413-3420.
5. Bosch, V., R. Bartenschlager, G. Radziwill, and H. Schaller. 1988. The duck hepatitis B virus P-gene codes for protein strongly associated with the 5′-end of the viral DNA minus strand. Virology 166:475-485.
6. Calvert, J., and J. Summers. 1994. Two regions of an avian hepadnavirus RNA pregenome are required in cis for encapsidation. J. Virol. 68:2084-2090.
7. Chang, L.-J., R. C. Hirsch, D. Ganem, and H. E. Varmus. 1990. Effects of insertional and point mutations on the functions of the duck hepatitis B virus polymerase. J. Virol. 64:5553-5558.
8. Condreay, L. D., T.-T. Wu, C. E. Aldrich, M. A. Delaney, J. Summers, C. Seeger, and W. S. Mason. 1992. Replication of DHBV genomes with mutations at the sites of initiation of minus-and plus-strand DNA synthesis. Virology 188:208-216.
9. Fallows, D. A., and S. P. Goff. 1995. Mutations in the Î sequences of human hepatitis B virus affect both RNA encapsidation and reverse transcription. J. Virol. 69:3067-3073.
10. Galibert, F., E. Mandart, F. Fitoussi, P. Tiollais, and P. Charnay. 1979. Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 281:646-650.
11. Ganem, D., and H. E. Varmus. 1987. The molecular biology of the hepatitis B viruses. Annu. Rev. Biochem. 56:651-693.
12. Hirsch, R. C., J. E. Lavine, L.-J. Chang, H. E. Varmus, and D. Ganem. 1990. Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription. Nature 344:552-555.
13. Hirsch, R. C., D. D. Loeb, J. R. Pollack, and D. Ganem. 1991. cis-acting sequences required for encapsidation of duck hepatitis B virus pregenomic RNA. J. Virol. 65:3309-3316.
14. Hu, J. M., and C. Seeger. 1996. Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase. Proc. Natl. Acad. Sci. USA 93:1060-1064.
15. Junker-Niepmann, M., R. Bartenschlager, and H. Schaller, 1990. A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA. EMBO J. 9:3389-3396.
16. Kaplan, P. M., R. L. Greenman, J. L. Gerin, R. H. Purcell, and W. S. Robinson. 1973. DNA polymerase associated with human hepatitis B antigen. J. Virol. 12:995-1005.
17. Knaus, T., and M. Nassal. 1993. The encapsidation signal on the hepatitis B virus RNA pregenome forms a stem-loop structure that is critical for its function. Nucleic Acids Res. 21:3967-3975.
18. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
19. Landers, T. A., H. B. Greenberg, and W. S. Robinson. 1977. Structure of hepatitis B Dane particle DNA and nature of the endogenous DNA polymerase reaction. J. Virol. 23:368-376.
20. Lanford, R. E., and J. S. Butel. 1979. Antigenic relationship of SV40 early proteins to purified large T polypeptide. Virology 97:295-306.
21. Lanford, R. E., K. D. Carey, L. E. Estlack, G. C. Smith, and R. V. Hay. 1989. Analysis of plasma protein and lipoprotein synthesis in long-term primary cultures of baboon hepatocytes maintained in serum-free medium. In Vitro Cell. Dev. Biol. 25:174-182.
22. Lanford, R. E., and L. Notvall. 1990. Expression of hepatitis B virus core and precore antigens in insect cells and characterization of a core-associated kinase activity. Virology 176:222-233.
23. Lanford, R. E., L. Notvall, and B. Beames. 1995. Nucleotide priming and reverse transcriptase activity of hepatitis B virus polymerase expressed in insect cells. J. Virol. 69:4431-4439.
24. Lien, J., D. J. Petcu, C. E. Aldrich, and W. S. Mason. 1987. Initiation and termination of duck hepatitis B virus DNA synthesis during virus maturation. J. Virol. 61:3832-3840.
25. Lien, J.-M., C. E. Aldrich, and W. S. Mason. 1986. Evidence that a capped oligorihonucleotide is the primer for duck hepatitis B virus plus-strand DNA synthesis. J. Virol. 57:229-236.
26. Loeb, D. D., and D. Ganem. 1993. Reverse transcription pathway of the hepatitis B viruses, p. 329-355. In A. M. Skalka and S. P. Goff (ed.), Reverse transcriptase. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. Loeb, D. D., R. C. Hirsch, and D. Ganem. 1991. Sequence-independent RNA cleavages generate the primers for plus strand DNA synthesis in hepatitis B viruses: implications for other reverse transcribing elements. EMBO J. 10: 3533-3540.
28. Luckow, V. A., S. C. Lee, G. F. Barry, and P. O. Olins. 1993. Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli. J. Virol. 67:4566-4579.
29. Molnar-Kimber, K. L., J. Summers, J. M. Taylor, and W. S. Mason. 1983. Protein covalently bound to minus-strand DNA intermediates of duck hepatitis B virus. J. Virol. 45:165-172.
30. Molnar-Kimber, K. L., J. W. Summers, and W. S. Mason. 1984. Mapping of the cohesive overlap of duck hepatitis B virus DNA and of the site of initiation of reverse transcription. J. Virol. 51:181-191.
31. Nassal, M., and A. Rieger. 1996. Bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesis. J. Virol. 70:2764-2773.
32. Pollack, J. R., and D. Ganem. 1993. An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsidation. J. Virol. 67:3254-3263.
33. Pollack, J. R., and D. Ganem. 1994. Site-specific RNA binding by a hepatitis B virus reverse transcriptase initiates two distinct reactions: RNA packaging and DNA synthesis. J. Virol. 68:5579-5587.
34. Radziwill, G., W. Tucker, and H. Schaller. 1990. Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity. J. Virol. 64:613-620.
35. Rieger, A., and M. Nassal. 1996. Specific hepatitis B virus minus-strand DNA synthesis requires only the 5′ encapsidation signal and the 3′-proximal direct repeat DR1*. J. Virol. 70:585-589.
36. Salas, M. 1991. Protein-priming of DNA replication. Annu. Rev. Biochem. 60:39-71.
37. Seeger, C., D. Ganem, and H. E. Varmus. 1986. Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science 232:477-484.
38. Seeger, C., and J. Maragos. 1989. Molecular analysis of the function of direct repeats and a polypurine tract for plus-strand DNA priming in woodchuck hepatitis virus. J. Virol. 63:1907-1915.
39. Seeger, C., and J. Maragos. 1990. Identification and characterization of the woodchuck hepatitis virus origin of DNA replication. J. Virol. 64:16-23.
40. Seeger, C., and J. Maragos. 1991. Identification of a signal necessary for initiation of reverse transcription of the hepadnavirus genome. J. Virol. 65:5190-5195.
41. Seeger, C., J. Summers, and W. S. Mason. 1991. Viral DNA synthesis. Curr. Top. Microbiol. Immunol. 168:41-60.
42. Seifer, M., and D. N. Standring. 1993. Recombinant human hepatitis B virus reverse transcriptase is active in the absence of the nucleocapsid or the viral replication origin, DR1. J. Virol. 67:4513-4520.
43. Staprans, S., D. D. Loeb, and D. Ganem. 1991. Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA. J. Virol. 65:1255-1262.
44. Summers, J., and W. S. Mason. 1982. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
45. Summers, J., A. O'Connell, and I. Millman. 1975. Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from dane particles. Proc. Natl. Acad. Sci. USA 72:4597-4601.
46. Summers, M. D., and G. E. Smith. 1987. A manual of methods for baculovirus vectors and insect cell culture procedures. Tex. Agric. Exp. Stn. Bull. 1555:1-48, plus appendix.
47. Tavis, J. E., and D. Ganem. 1993. Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription. Proc. Natl. Acad. Sci. USA 90:4107-4111.
48. Tavis, J. E., and D. Ganem. 1996. Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template. J. Virol. 70:5741-5750.
49. Tavis, J. E., S. Perri, and D. Ganem. 1994. Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer. J. Virol. 68:3536-3543.
50. Wang, G.-H., and C. Seeger. 1992. The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis. Cell 71:663-670.
51. Wang, G.-H., and C. Seeger. 1993. Novel mechanism for reverse transcription in hepatitis B viruses. J. Virol. 67:6507-6512.
52. Wang, G.-H., F. Zoulim, E. H. Leber, J. Kitson, and C. Seeger. 1994. Role of RNA in enzymatic activity of the reverse transcriptase of hepatitis B viruses. J. Virol. 68:8437-8442.
53. Weber, M., V. Bronsema, H. Bartos, A. Bosserhoff, R. Baltenschlager, and H. Schaller. 1994. Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription. J. Virol. 68:2994-2999.
54. Will, H., W. Reiser, T. Weimer, E. Pfaff, M. Büscher, R. Sprengel, R. Cattaneo, and H. Schaller. 1987. Replication strategy of human hepatitis B virus. J. Virol. 61:904-911.
55. Wu, T.-T., L. D. Condreay, L. Coates, C. Aldrich, and W. Mason. 1991. Evidence that less-than-full-length cis gene products are functional in hepadnavirus DNA synthesis. J. Virol. 65:2155-2163.
56. Zoulim, F., and C. Seeger. 1994. Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. J. Virol. 68:6-13.