Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template

Journal of Virology

Volumn 70, Issue 9, 1996, Pages 5741-5750

  Tavis, John E ^a   Ganem, Don ^b  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; VIRUS ENZYME;

ARTICLE; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; HEPATITIS B VIRUS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; RNA BINDING; VIRUS REPLICATION;

EID: 0029833252     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.9.5741-5750.1996     Document Type: Article

References (29)

1. Bohen, S. P., A. Kralli, and K. R. Yamamoto. 1995. Hold 'em and fold 'em: chaperones and signal transduction. Science 268:1303-1304.
2. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991-1995.
3. Clark, J. M. 1988. Novel non-templated addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases. Nucleic Acids Res. 16:9677-9686.
4. Ganem, D., J. R. Pollack, and J. E. Tavis. 1994. Hepatitis B virus reverse transcriptase and its many roles in hepadnaviral genomic replication. Infect. Agents Dis. 3:85-93.
5. Gething, M.-J., and J. Sambrook. 1992. Protein folding in the cell. Nature (London) 355:33-44.
6. Hartl, F.-U., R. Hlodan, and T. Langer. 1994. Molecular chaperones in protein folding: the art of avoiding sticky situations. Trends Biochem. Sci. 19:20-25.
7. Hendrick, J. P., and F.-U. Hartl. 1993. Molecular chaperone functions of heat-shock proteins. Annu. Rev. Biochem. 62:349-384.
8. Hu, J., and C. Seeger. 1996. Hsp90 is required for the activity of a hepatitis b virus reverse transcriptase. Proc. Natl. Acad. Sci. USA 93:1060-1064.
9. Huovila, A. J., A. M. Eder, and S. D. Fuller. 1992. Hepatitis B surface antigen assembles in a post-ER, pre-Golgi compartment. J. Cell Biol. 118:1305-1320.
10. Inouye, S., and M. Inouye. 1993. Bacterial reverse transcription, p. 391-410. In A. M. Skalka and S. P. Goff (ed.), Reverse transcriptase. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
11. Jakob, U., and J. Buchner. 1994. Assisting spontaneity: the role of Hsp90 and small Hsps as molecular chaperones. Trends Biochem. Sci. 19:205-211.
12. Kimura, Y., I. Yahara, and S. Lindquist. 1995. Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways. Science 268:1362-1365.
13. Kolodziej, P. A., and R. A. Young. 1991. Epitope tagging and protein surveillance. Methods Enzymol. 194:508-519.
14. Loeb, D. D., and D. Ganem. 1993. Reverse transcription pathway of the hepatitis B viruses, p. 329-355. In A. M. Skalka and S. P. Goff (ed.), Reverse transcriptase. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
15. Patzer, E. J., G. R. Nakamura, C. C. Simonsen, A. D. Levinson, and R. Brands. 1986. Intracellular assembly and packaging of hepatitis B surface antigen particles occur in the endoplasmic reticulum. J. Virol. 58:884-892.
16. Pollack, J. R., and D. Ganem. 1994. Site-specific RNA binding by a hepatitis B virus reverse transcriptase initiates two distinct reactions: RNA packaging and DNA synthesis. J. Virol. 68:5579-5587.
17. Radziwill, G., H. Zentgraf, H. Schaller, and V. Bosch. 1988. The duck hepatitis B virus DNA polymerase is tightly associated with the viral core structure and unable to switch to an exogenous template. Virology 163:123-132.
18. Seifer, M., and D. N. Standring. 1993. Recombinant human hepatitis B virus reverse transcriptase is active in the absence of the nucleocapsid or the viral replication origin, DR1. J. Virol. 67:4513-4520.
19. Simon, K., V. R. Lingappa, and D. Ganem. 1988. Secreted hepatitis B surface antigen polypeptides are derived from a transmembrane precursor. J. Cell Biol. 107:2163-2168.
20. Summers, J., and W. S. Mason. 1982. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
21. Tavis, J. E. Unpublished data.
22. Tavis, J. E., and D. Ganem. 1993. Expression of functional hepatitis B virus polymerase in yeast reveals it to be the sole viral protein required for correct initiation of reverse transcription. Proc. Natl. Acad. Sci. USA 90:4107-4111.
23. Tavis, J. E., and D. Ganem. 1995. RNA sequences controlling the initiation and transfer of duck hepatitis B virus minus-strand DNA. J. Virol. 69:4283-4291.
24. Tavis, J. E., S. Perri, and D. Ganem. 1994. Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer. J. Virol. 68:3536-3543.
25. Wang, G.-H., and C. Seeger. 1992. The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis. Cell 71:663-670.
26. Wang, G.-H., and C. Seeger. 1993. Novel mechanism for reverse transcription in hepatitis B viruses. J. Virol. 67:6507-6512.
27. Wang, G.-H., F. Zoulim, E. H. Leber, J. Kitson, and C. Seeger. 1994. Role of RNA in enzymatic activity of the reverse transcriptase of hepatitis B viruses. J. Virol. 68:8437-8442.
28. Weber, M., V. Bransema, H. Bartos, A. Bosserhoff, R. Bartenschlager, and H. Schaller. 1994. Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription. J. Virol. 68:2994-2999.
29. Zoulim, F., and C. Seeger. 1994. Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. J. Virol. 68:6-13.