How a poliovirus might cause schizophrenia: A commentary on Eagles' hypothesis

Neurochemical Research

Volumn 22, Issue 5, 1997, Pages 647-656

  Squires, R F ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

Eagle's hypothesis; Poliovirus; schizophrenia

Indexed keywords

ARTICLE; HUMAN; HYPOTHESIS; INFLUENZA; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; SCHIZOPHRENIA; TWIN DISCORDANCE; VIRUS ETIOLOGY; VIRUS PATHOGENESIS;

CICONIIFORMES; POLIOVIRUS;

EID: 0030896738     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022486423238     Document Type: Article

References (93)

1. Eagles, J. M. 1992. Are polioviruses a cause of schizophrenia? Br. J. Psychiat. 160:598-600.
2. Squires, R. F., and Saederup, E. 1991. A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of "functional" psychoses. Neurochem. Res. 16:1099-1111.
3. Squires, R. F., and Saederup, E. 1997. Clozapine and some other antipsychotic drugs may preferentially block the same subset of GABAA receptors. Neurochem. Res. 22:151-162.
4. Squires, R. F. 1992. Are polioviruses a cause of schizophrenia? Br. J. Psychiat. 161:427 (Letter to Editor).
5. 3H]flunitrazepam binding in cingulate cortex and hippocampus of postmortem schizophrenic brains: is selective loss of glutamatergic neurons associated with major psychoses? Neurochem. Res. 18:219-223.
6. Torrey, E. F. 1988. Stalking the schizovirus. Schizophrenia Bull. 14:223-229.
7. Torrey, E. F. 1991. A viral-anatomical explanation of schizophrenia. Schizophrenia Bull. 17:15-18.
8. Kaufmann, C. A., Weinberger, D. R., Stevens, J. R., Asher, D. M., Kleinman, J. E., Sulima, M. P., Gibbs, C. J., Jr., and Gajdusek, C. 1988. Intracerebral inoculation of experimental animals with brain tissue from patients with schizophrenia. Arch. Gen. Psychiat. 45:648-652.
9. Taller, A. M., Asher, D. M., Pomeroy, K. L., Eldadah, B. A., Godec, M. S., Falkai, P. G., Bogert, B., Kleinman, J. E., Stevens, J. R., and Torrey, E. F. 1996. Search for viral nucleic acid sequences in brain tissues of patients with schizophrenia using nested polymerase chain reaction. Arch. Gen. Psychiat. 53:32-40.
10. Torrey, E. F., Rawlings, R., and Waldman, I. N. 1988. Schizophrenia births and viral diseases in two states. Schizo. Res. 1:73-77.
11. Bodian, D. 1947. Poliomyelitis. Neuropathologic observations in relation to motor symptoms. J. Amer. Med. Assoc. 134:1149-1154.
12. Johnson, R. T. 1985. Acute anterior poliomyelitis. In: Wyngaarden, J. B., Smith, L. H. Jr. (Eds), Cecil Textbook of Medicine. W. B. Saunders, 2130-2132.
13. Ren, R., and Racaniello, V. R. 1992. Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice. J. Virol. 66:296-304.
14. Brown, R. H., Jr., Johnson, D., Ogonowski, M., and Weiner, H. L. 1987. Type I human poliovirus binds to human synaptosomes. Ann. Neurol. 21:64-70.
15. A receptor subunit for benzodiazepine pharmacology. Nature 338:582-585.
16. A benzodiazepine receptors produced in transfected cells. Science 245:1389-1392.
17. Deng, H., Liu, R., Ellmeir, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R., and Landau, N. R. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
18. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667-673.
19. Morris, P. J. and Pietsch, M. C. 1973. A possible association between paralytic poliomyelitis and multiple sclerosis. Lancet II:847.
20. Pietsch, M. C., and Morris, P. J. 1974. An association of HL-A3 and HL-A7 with paralytic poliomyelitis. Tissue Antigen 4:50-55.
21. Steigman, A. J. 1973. HL-A types and paralytic poliomyelitis. Lancet II:1383.
22. Torrey, E. F., Bowler, A. E., Taylor, E. H., and Gottesman, I.I. 1994. Schizophrenia and Manic-Depressive Disorder, Basic Books, New York, N.Y.
23. Gregersen, P. K. 1993. Discordance for autoimmunity in monozygotic twins. Are "identical" twins really identical? Arthritis Rheum. 36:1185-1192.
24. Ivanyi, P., Droes, J., Schreuder, G. M. Th., D'Amaro, J., and van Rood, J. J. 1983. A search for association of HLA antigens with paranoid schizophrenia. Tissue Antigen 22:186-193.
25. Miyanaga, K., Machiyama, Y., and Juji, T. 1984. Schizophrenic disorders and HLA-DR antigens. Biol. Psychiat. 19:121-129.
26. Cazzullo, C. L., Smeraldi, E., and Penati, G. 1974. The leukocyte antigenic system HL-A as a possible genetic marker of schizophrenia. Brit. J. Psychiat. 125:25-27.
27. Gattaz, W. F., Beckmann, H., and Mendlewicz, J. 1981. HLA antigens and schizophrenia: a pool of two studies. Psychiat. Res. 5:123-128.
28. McGuffin, P., Farmer, A. E., and Yonace, A. H. 1981. HLA antigens and subtypes of schizophrenia. Psychiat. Res. 5:115-122.
29. Crowe, R. R., Thompson, J. S., Flink, R., and Weinberger, B. 1979. HLA antigens and schizophrenia. Arch. Gen. Psychiat. 36: 231-233.
30. Özcan, M. E., Taskin, R., Banoglu, R., Babacan, M., and Tuncer, E. 1996. HLA antigens in schizophrenia and mood disorders. Biol. Psychiat. 39:891-895.
31. Nimgaonkar, V. L., Rudert, W. A., Zhang, X. R., Tsoi, W-F., Trucco, M., and Saha, N. 1995. Further evidence for an association between schizophrenia and the HLA DQB1 gene locus. Schizophr. Res. 18:43-49,
32. Eaton, W. W., Hayward, C., and Ram, R. 1992. Schizophrenia and rheumatoid arthritis: a review. Schizophr. Res. 6:181-192.
33. Feldmann, M., Brennan, F. M., and Maini, R. N. 1996. Rheumatoid arthritis. Cell 85:307-310.
34. Wright, P., Sham, P. C., Gilvarry, C. M., Jones, P. B., Cannon, M., Sharma, T., and Murray, R. M. 1996. Autoimmune diseases in the pedigrees of schizophrenic and control subjects. Schizophr. Res. 20:261-267.
35. Wright, P., Donaldson, P. T., Underhill, J. A., Choudhuri, K., Doherty, D. G., and Murray, R. M. 1996. Genetic association of the HLA DRB1 gene locus on chromosome 6p21.3 with schizophrenia. Amer. J. Psychit. 153:1530-1533.
36. Straub, R. E., MacLean, C. J., O'Neill, F. A., Burke, J., Murphy, B., Duke, F., Shinkwin, R., Webb, B. T., Zhang, J., Walsh, D., and Kendler, K. S. 1995. A potential vulnerability locus for schizophrenia on chromosome 6p24-22 evidence for genetic heterogeneity. Nat. Genet. 11:287-293.
37. Schwab, S. G., Albus, M., Hallmayer, J., Hönig, S., Borrmann, M., Lichtermann, D., Ebstein, R. P., Ackenheil, M., Lerer, B., Risch, N., Maier, W., and Wildenauer, D. B. 1995. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat. Genet. 11:325-327.
38. Moises, H. W., Yang, L., Kristbjarnarson, H., Wiese, C., Byerley, W., Macciardi, F., Arolt, V., Blackwood, D., Liu, X., Sjögren, B., Aschauer, H. N., Hwu, H.-G., Jang, K., Livesley, W. J., Kennedy, J. L., Zoega, T., Ivarsson, O., Bui, M.-T., Yu, M.-H., Havsteen, B., Commenges, D., Weissenbach, J., Schwinger, E., Gottesman, I. I., Pakstis, A. J., Wetterberg, L., Kidd, K. K., and Helgason, T. 1995. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat. Genet. 11:321-324.
39. Alexander, R. C., Coggiano, M., Daniel, D. C., and Wyatt, R. J. 1990. HLA antigens in schizophrenia. Psychiat. Res. 31:221-233.
40. Campion, D., Leboyer, M., Hillaire, D., Halle, L., Gorwood, P., Cavelier, B., Soufflet, M. F., D'Amato, T., Muller, B., Kaplan, C., Jay, M., and Clerget-Darpoux, F. 1992. Relationship of HLA to schizophrenia not supported in multiplex families. Psychiat. Res. 41:99-105.
41. Wekerle, H., Linington, C., Lassmann, H., and Meyermann, R. 1986. Cellular immune reactivity within the CNS. TINS 9:271-277.
42. Luber-Narod, J., and Rogers, J. 1988. Immune system associated antigens expressed by cells of the human central nervous system. Neurosci. Lett. 94:17-22.
43. Aldrich, M. S. 1992. Narcolepsy. Neurology 42:34-43.
44. Douglass, A. B., Harris, L., and Pazderka, F. 1989. Monozygotic twins concordant for the narcoleptic syndrome. Neurology 39: 140-141.
45. Montplaisir, J., and Poirier, G. 1987. Narcolepsy in monozygotic twins. Neurology 37:1089.
46. Billiard, M., and Seignalet, J. 1985. Extraordinary association between HLA-DR2 and narcolepsy. Lancet I:226-227.
47. Marcadet, A., Gebuhrer, L., Betuel, H., Seignalet, J., Freidel, A. C., Confavreux, C., Billiard, M., Dausett, J., and Cohen, D. 1985. DNA polymorphism related to HLA-DR2 Dw2 in patients with narcolepsy. Immunogenetics 22:679-683.
48. Douglass, A. B., Hays, P., Pazderka, F., and Russell, J. M. 1991. Florid refractory schizophrenias that turn out to be treatable variants of HLA-associated narcolepsy. J. Nerv. Ment. Dis. 179:12-17.
49. Roy, A. 1976. Psychiatric aspects of narcolepsy. Brit. J. Psychiat. 128:562-565.
50. Franco, B., Guioli, S., Pragliola, A., Incerti, B., Bardoni, B., Tonlorenzi, R., Carrozzo, R., Maestrini, E., Pieretti, M., Taillon-Miller, P., Brown, C. J., Willard, H. F., Lawrence, C., Persico, M. G., Camerino, G., and Ballabio, A. 1991. A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules. Nature 353:529-536.
51. Legouis, R., Hardelin, J.-P., Levilliers, J., Claverie, J.-M., Compain, S., Wunderle, V., Millasseau, P., Le Paslier, D., Cohen, D., Caterina, D., Bougueleret L., Delemarre-Van de Waal, H., Lutfalla, G., Weissenbach, J., and Petit, C. 1991. The candidate gene for the x-linked Kallmann syndrome encodes a protein related to adhesion molecules. Cell 67:423-435.
52. Cowen, M. A., and Green, M. 1993. The Kallmann's syndrome variant (KSV) model of the schizophrenias. Schizo. Res. 9:1-10.
53. Crow, T. J. 1993. Sexual selection, Machiavellian intelligence, and the origins of psychosis. Lancet 342:594-598.
54. Benes, F. M., Davidson, J., and Bird, E. D. 1986. Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch. Gen. Psychiat. 43:31-35.
55. Meltzer, H. Y., and Crayton, J. W. 1974. Subterminal motor nerve abnormalities in psychotic patients. Nature 249:373-375.
56. Crayton, J. W., and Meltzer, H. Y. 1979. Degeneration and regeneration of motor neurons in psychotic patients. Biol. Psychiat. 14:803-819.
57. Howland, R. H. 1990. Schizophrenia and amyotrophic lateral sclerosis. Compr. Psychiat. 31:327-336.
58. Karson, C. N., Casanova, M. F., Kleinman, J. E., and Griffin, W. S. T. 1993. Choline acetyltransferase in schizophrenia. Amer. J. Psychiat. 150:454-459.
59. Mednick, S. A., Machon, R. A., Huttunen, M. O., and Bonett, D. 1988. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch. Gen. Psychiat. 45:189-192.
60. Barr, C. E., Mednick, S. A., and Munk-Jorgensen, P. 1990. Exposure to influenza epidemics during gestation and adult schizophrenia. Arch. Gen. Psychiat. 47:869-874.
61. O'Callaghan, E., Sham, P., Takei, N., Glover, G., and Murray, R. M. 1991. Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet 337:1248-1250.
62. Sham, P. C., O'Callaghan, E., Takei, N., Murray, G. K., Hare, E. H., and Murray, R. M. 1992. Schizophrenia following prenatal exposure to influenza epidemics between 1939 and 1960. Brit. J. Psychiat. 160:461-466.
63. Kendell, R. E., and Kemp, I. W. 1989. Maternal influenza in the etiology of schizophrenia. Arch. Gen. Psychiat. 46:878-882.
64. Crow, T. J., and Done, D. J. 1992. Prenatal exposure to influenza does not cause schizophrenia. Brit. J. Psychiat. 161:390-393.
65. Crow, T. J. 1994. Prenatal exposure to influenza as a cause of schizophrenia. Brit. J. Psychiat. 164:588-592.
66. Selten, J.-P. C. J., and Slaets, J. P. J. 1994. Evidence against maternal influenza as a risk factor for schizophrenia. Brit. J. Psychiat. 164:674-676.
67. Susser, E., Lin, S. P., Brown, A. S., Lumey, L. H., and Erlenmeyer-Kimling, L. 1994. No relation between risk of schizophrenia and prenatal exposure to influenza in Holland. Amer. J. Psychiat. 151:922-924.
68. Douglas, R. G., Jr. 1985. Influenza. In: J. B. Wyngaarden, J. B. Smith, L. H., Jr. (Eds). Cecil Textbook of Medicine. W. B. Saunders, pp. 1700-1705.
69. Menninger, K. A. 1926. Influenza and schizophrenia. Amer. J. Psychiat. V:469-529.
70. Paul, J. R. 1971. A History of Poliomyelitis, Yale University Press, New Haven and London.
71. Parish, J. G. 1978. Early outbreaks of 'epidemic neuromyasthenia.' Postgrad. Med. J. 54:711-717.
72. Gow, J. W., Behan, W. M. H., Clements, G. B., Woodall, C., Riding, M., and Behan, P. O. 1991. Enteroviral RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome. BMJ 302:692-696.
73. Davis, J. O., and Phelps, J. A. 1995. Twins with schizophrenia: genes or germs? Schizophrenia Bull. 21:13-18.
74. Davis, J. O., Phelps, A., and Bracha, H. S. 1995. Prenatal development of monozygotic twins and concordance for schizophrenia. Schizophrenia Bull. 21:357-366.
75. Zhang, L., van Rood, J. J., and Claas, F. H. J. 1991. The T-cell repertoire is not dictated by self antigens alone. Res. Immunol. 142:441-445.
76. Birnbaum, G., Kotilinek, L., Schwartz, M., and Sternad, M. 1986. Disparate responses of lymphocyte clones to cells of monozygotic twins discordant for multiple sclerosis. J. Neuroimmunol. 11:237-243.
77. Utz, U., Biddlson, W. E., McFarland, H. F., McFarlin, D. E., Flerlage, M., and Martin, R. 1993. Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis. Nature 364:243-247.
78. Oettinger, M. A., Schatz, D. G., Gorka, C., and Baltimore, D. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523.
79. Chun, M. J. M., Schatz, D. G., Oettinger, M. A., Jaenisch, R., and Baltimore, D. 1991. The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell 64:189-200.
80. Matsuoka, M., Nagawa, F., Okazaki, K., Kingsbury, L., Yoshida, K., Müller, U., Larue, D. T., Winer, J. A., and Sakano, H. 1991. Detection of somatic DNA recombination in the transgenic mouse brain. Science 254:81-86.
81. Singer-Sam, J. 1991. An epigenetic role in schizophrenia. Schizophrenia Bull. 17:365.
82. Huttenlocher, P. R. 1979. Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res. 163: 195-205.
83. Zecevic, N., Bourgeois, J.-P., and Rakic, P. 1989. Changes in synaptic density in motor cortex of rhesus monkey during fetal and postnatal life. Develop. Brain Res. 50:11-32.
84. Bourgeois, J.-P., and Rakic, P. 1993. Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage. J. Neurosci. 13:2801-2820.
85. Feinberg, I. 1982-83. Schizophrenia: caused by a fault in programmed synaptic elimination during adolescence? J. Psychiat. Res. 17:319-334.
86. Keshavan, M. S., Anderson, S., and Pettegrew, J. W. 1994. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. J. Psychiat. Res. 28: 239-265.
87. Weinberger, D. R. 1987. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiat. 44:660-669.
88. Fañanas, L., van Os, J., Hoyos, C., McGrath, J., Mellor, C. S., and Murray, R. 1996. Dermatoglyphic a-b ridge count as a possible marker for developmental disturbance in schizophrenia: replication in two samples. Schizophr. Res. 20:307-314.
89. Davis, J. O., and Bracha, H. S. 1996. Prenatal growth markers in schizophrenia. A monozygotic co-twin control study. Amer. J. Psychiat. 153:1166-1172.
90. Eberle, K. E., Nguyen, V. T., and Freistadt, M. S. 1995. Low levels of poliovirus replication in primary human monocytes: possible interactions with lymphocytes. Arch. Virol. 140:2135-2150.
91. Freistadt, M. S., and Eberle, K. E. 1996. Correlation between poliovirus type 1 mahoney replication in blood cells and neurovirulence. J. Virol. 70:6486-6492.
92. Blinzinger, K., Simon, J., Magrath, D., and Boulger, L. 1969. Poliovirus crystals within the endoplasmic reticulum of endothelial and mononuclear cells in the monkey spinal cord. Science 163: 1336-1337.
93. Kowall, N. W., and Beal, M. F. 1991. Glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease. Ann. Neurol. 29:162-167.