Antigenic and molecular structure of the mite allergen der p 2

International Archives of Allergy and Immunology

Volumn 113, Issue 1-3, 1997, Pages 99-101

  Smith, Alisa M ^a   Taketomi, Ernesto A ^a   Mueller, Geoffrey A ^b   Rule, Gordon S ^b   Benjamin, David C ^b   Chapman, Martin D ^a  

^a Asthma and Allergic Diseases Center   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Antigenic determinant; Antigenic variants; Dermatophagoides pteronyssinus; IgE antibody; Mutagenesis; Tertiary structure

Indexed keywords

EPITOPE; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E;

CONFERENCE PAPER; DERMATOPHAGOIDES PTERONYSSINUS; HOUSE DUST ALLERGY; HUMAN; MITE; MUTAGENESIS; PRIORITY JOURNAL;

EID: 0030892511     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237517     Document Type: Article

References (9)

1. Lombardero M, Heymann PW, Platts-Mills TAE, Fox JW, Chapman MD: Conformational stability of B cell epitopes on group I and group II Dermalophagoides spp allergens: Effect of thermal and chemical dcnaturation on the binding of murine IgG and human IgE antibodies, J Immunol 1990;144:1353-1360.
2. C’hua KY, Greene WK, Kchal P, Thomas WR: IgE binding studies with large peptides expressed from Derp2 cDNA constructs, Clin Exp Allergy 1991;21:161-166.
3. van tHof W, Driedck PC, van den Berg M, Beck-Sickinger AG, Jung G, Aalberse RC': Epitope mapping of the Dermalophagoides pte-ronyssimis house dust mite major allergen Der p 2 using overlapping synthetic peptides, Mol Immunol 1991:28:1225-1232.
4. Benjamin DC, Perdue SS: Site-directed mutagenesis in epitope mapping, Methods (Companion to Methods Enzymol) 1996:9:508-515.
5. Hopp T, Woods K: Prediction of protein antigenic determinants from amino acid sequences, Proc Natl Acad Sci USA 1981;78:3824-3828.
6. Smith AM, Chapman MD: Reduction in IgE binding to allergen variants generated by site-directed mutagenesis: Contribution of disulfide bonds to the antigenic structure of the major house dust mite allergen Der p 2. Mol Immunol 1996:33:399-405.
7. Taketomi EA, Sung SJ, Slunt, JB, Smith AM, Platts-Mills TAE, Fu SM: Dendritic cells and B cells in rDer p 2 presentation to memory and naive T cells from atopic patients, J Allergy Clin Immunol 1996:97:296.
8. Smith AM, Chapman MD: Localization of antigenic sites on Der p 2 using oligonuclcotidc-di-rcctcd mutagenesis targeted to predicted surface residues, Clin Exp Allergy, 1997. in press
9. Ovsyannikova I, Vailcs LD, Li Y, Heymann PW, Chapman MD: Monoclonal antibodies to group II Dermalophagoides spp allergens: Murine immune response, epitope analysis, and development of a two site ELISA, J Allergy Clin Immunol 1994:94:537-546