T helper cells driving pathogenic anti-DNA autoantibody production in lupus: Nucleosomal epitopes and CD40 ligand signals

Lupus

Volumn 6, Issue 3, 1997, Pages 333-336

  Datta, S K ^a   Kaliyaperumal, A ^a   Mohan, C ^a   Desai Mehta, Ami ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Autoimmune disease; Co stimulatory signals; Helper inducer T cells; Immunotherapy; Systemic lupus erythematosus; T cell receptors

Indexed keywords

AUTOANTIBODY; DNA ANTIBODY; EPITOPE; GLYCOPROTEIN GP 39;

CONFERENCE PAPER; HELPER CELL; IMMUNOPATHOGENESIS; NUCLEOSOME; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0030890284     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/096120339700600330     Document Type: Conference Paper

References (4)

1. Datt SK, Desai-Mehta A, Mohan C. Mechanisms of the pathogenic autoimmune response in lupus: Prospects for specific immunotherapy. Immunol Res 1995; 14: 132-147.
2. Datta SK, Kaliyaperumal A. Nucleosome driven autoimmune response in lupus: Pathogenic T helper epitopes and costimulatory signals. In 'B Lymphocytes in Autoimmunity.' Ann NY Acad Sci April, 1997 (in press).
3. Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 1996; 97: 2063-2073.
4. Kaliyaperumal A, Mohan C, Wu W, Datta SK. Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J Exp Med 1996; 183: 2459-2469.