The molecular genetics of mood disorders

Current Opinion in Psychiatry

Volumn 10, Issue 2, 1997, Pages 79-83

  Holmes, Clive ^a   Lovestone, Simon ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; HUMAN; MANIC DEPRESSIVE PSYCHOSIS; MOLECULAR GENETICS; MOOD; SHORT SURVEY;

EID: 0030888891     PISSN: 09517367     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001504-199703000-00004     Document Type: Short Survey

References (45)

1. Comings DE: Candidate genes and association studies in psychiatry. Am J Med Genet 1994, 54:324-325.
2. Nöthen MM, Propping P, Fimmers R: Association versus linkage studies in psychosis genetics. J Med Genetics 1992, 30:634 7.
3. Slater E, Cowie V: The genetics of mental disorder. London: Oxford University Press; 1971.
4. McGuffun P, Katz R: Nature, nurture and affective disorder. In The biology of depression. Edited by Deakin JFW. London: Gaskill; 1986:26 51.
5. Reich T, Clayton PJ, Winokur G: Family history studies. V. The genetics of mania. Am J Psychiatry 1969, 125:1358 1369.
6. Mendlewicz J, Simon P, Sevy S: Polymorphic DNA marker and X chromosome and manic depression. Lancet 1987, 1:1230 1232.
7. Egeland JA, Gerhard DS, Pauls DL, Susses JN, Kidd KK, Allen CR, Hostetter AM, Houseman DE: Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 1987, 325:783 787.
8. Coon H, Jensen S, Hoff M, Holik J, Plaetke R, Reimherr F, Wender P, Leppert M, Byerley W: A genome-wide search for genes predisposing to manic depression assuming autosomal dominant inheritance. Am J Hum Genet 1993, 52:11234 11249.
9. Craddock N, Owen M, Burge S, Kurian B, Thomas P, McGuffin P: Family cosegregation of major affective disorders and Darrier's disease (Keratosis-Follicularis). Br J Psychiatry 1994, 164:355 358.
10. Straub RE, Lehner T, Luo Y: A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nature Genet 1994, 8:291-296.
11. Berrettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberger JIJ, Gershon ES: Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci U S A 1994, 91:5918 5921.
12. Risch N, Botstein D: A manic depressive history. Nature Genet 1996, 12:351 353.
13. Byerley B, Holik J, Hoff M, Coon H: Search for a gene predisposing to manic-depression on chromosome 21. Am J Med Genet 1995, 60:231 233.
14. Pekkarinen P, Terwilliiger J, Bredbacka PE, Lonnqvist J, Peltonen L: Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree. Genome Res 1995, 5:105 113.
15. Smyth C, Kalsi G, Brynjolfsson J, O'Neil J, Curtis D, Rifkin L, Moloney E, Murphy P, Sherrington R, Petursson H, Gurling H: Further tests for linkage of bipolar affective-disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective-disorder pedigrees. Am J Psychiatry 1996, 153:271 274.
16. Shah M, Coon H, Holik J, Hoff M, Helmer V, Panos P, Byerley B: Mutation scan of the D1 dopamine receptor gene in 22 cases of bipolar 1 disorder. Am J Med Genet 1995, 60:150 153.
17. Dawson E, Parfitt E, Roberts Q, Daniels J, Lim L, Sham P, Nothen M, Propping P, Lanczik M, Maier W et al.: Linkage studies of bipolar disorder in the region of the Darrier's disease gene on chromosome 12q23-24.1. Am J Med Genet 1995, 60:94-102.
18. Dawson E, Gill M, Curtis D, Castle D, Hunt N, Murray RM, Powell JF: Genetic association between alleles of pancreatic phospholipase A2 gene and bipolar affective disorder. Psychiatr Genet 1995, 5:177 180.
19. Toumier-Lasserve E, Joutel A, Melki-J, Weissenbach J, Lathrop GM, Chabriat H, Mas JL, Cabaric EA, Baudrimont M, Maciazek J et al.: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12. Nature Genet 1993, 3:256-9
20. Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, Alamowitch S, Domenga V, Cecillion M, Marechal E et al.: Notch 3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 1996, 383:707 710.
21. Maier W, Hallmayer J, Zill P, Bondy B, Lichtermann D, Ackenheil M, Minges J, Wildenauer D: Linkage analysis between pericentrometric markers on chromosome 18 and bipolar disorder: a replication test. Psychiatr Res 1995, 59:7 15.
22. Stine OC, Xu J, Koskela R, McMahon FJ, Gschwend M, Friddle C, Clark CD, Mclnnis MG, Simpson SG, Breschel TS et al.: Evidence for linkage of bipolar disorder to chromosome 18 with parent-of-origin effect. Am J Hum Genet 1995, 57:1384 1394. A small study but the finding of linkage to chromosome 18 confirms other studies. Of most interest is the suggestion of a parent-of-origin effect with chromosome 18 markers showing linkage to paternally inherited disease.
23. Freimer NB, Reus VI, Escamilla MA, Mclnnis LA, Spesny M, Leon P, Service SK, Smith LB, Silva S, Rojas E et al.: Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23. Nature Genet 1996, 12:436-441. Genetically isolated pedigrees are highly informative and this group examined two such pedigrees with a combination of genetic approaches strongly implicating a small region of chromosome 18.
24. Pauls DL, Ott J, Paul SM, Allen CR, Fann CSJ, Carulli JP, Falls KM, Bouthillier CA, Gravius TC, Keith TP et al.: Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish. Am J Hum Genet 1995, 57:636 643.
25. Gershon ES, Goldin LR, Badner JA, Berrettini WH: Detection of linkage to affective disorders in the catalogued Amish pedigrees: a reply to Pauls et at. Am J Hum Genet 1996, 58:1381 1384.
26. Ginns EI, Ott J, Egeland JA, Allen CR, Fann CSJ, Pauls DL, Weissenbach J, Carulli JP, Falls KM, Keith TP, Paul SM: A genome wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nature Genet 1996, 12:431 435. The authors report linkage to three new sites on chromosomes 6,13 and 15 but with low LOD scores.
27. Pauls DL, Bailey JN, Carter AS, Allen CR, Egeland JA: Complex segregation analyses of Old Order Amish families ascertained through bipolar I individuals. Am J Med Genet 1995, 60:290 297. An analysis of the fascinating Amish data indicating that closely related subsets of families show an autosomal dominant mode of transmission of bipolar illness but that more distantly related families are more likely to be polygenic or oligogenic.
28. Ewald H, Mors O, Flint T, Koed K, Eiberg H, Kruse TA: A possible locus for manic depressive illness on chromosome 16p13. Psychiatr Genet 1995, 5:71 81.
29. Blackwood DHR, He L, Morris SW, McLean A, Whitton C, Thomson M, Walker MT, Woodburn K, Sharp CM, Wright AF et al.: A locus for bipolar affective disorder on chromosome 4p. Nature Genet 1996,12:427 430.
30. Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ, Pauls DL, Long RT, Kidd KK, Giovanni C et al.: Reevaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 1989, 342:238 243.
31. McGuffin P, Sargeant M: Genetic markers and affective disorder. In The new genetics of mental illness. Edited by McGuffin P, Murray R. Oxford: Butterworth Heinemann; 1991:27 43.
32. Kawada Y, Hattori M, Fukuda R, Arai H, Inoue R, Nanko S: No evidence of linkage or association between tyrosine hydroxylase gene and affective disorder. J Affect Disord 1995, 34:89-94.
33. Meloni R, Leboyer M, Bellivier F, Barbe B, Samolyk D, Allilaire JF, Mallet J: Association of manic-depressive illness with tyrosine hydroxylase microsatelllte marker [Letter]. Lancet 1995, 345:932.
34. Lim L, Powell JF, Sham P, Castle D, Hunt N, Murray RM, Gill M: Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder. Am J Med Genet 1995, 60:325 331.
35. Craddock N, Daniels J, Roberts E, Rees M, McGuffin P, Owen M: No evidence for allelic association between bipolar disorder and monoamine oxidase A gene polymorphisms. Am J Med Genet 1995, 60:322 324.
36. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CAD: Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996, 347:731 733.
37. Collier DA, Arranz MJ, Sham P, Battersby S, Gill P, Aitchison KJ, Sodhi M, Li T, Smith B, Morton J et al.: A VNTR in the serotonin transporter is a potential susceptibility factor for bipolar affective disorder. Neuro-report 1996, 7:1675 1679.
38. 2A receptor gene and bipolar affective disorder [Letter]. Lancet 1995, 346:969.
39. Gutierrez B, Fananas L, Arranz MJ, Valles V, Guillamat R, Vanos J, Collier D: Allelic association analysis of the 5HT-2 receptor gene in bipolar affective-disorder. Neurosci Lett 1996, 212:65 67.
40. Manki H, Kanba S, Muramatsu T, Higuchi S, Suzuki E, Matsushita S, Ono Y, Chiba H, Shintani F, Nakamura M et al.: Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders. J Affect Disord 1996, 40:7 13.
41. Gelernter J: Genetics of bipolar affective disorder: time for another reinvention? Am J Hum Genet 1995, 56:1262 1266.
42. Engstrom C, Thornlund A, Johansson E, Langstrom M, Chotai J, Adolfsson R, Nylander P: Anticipation in unipolar affective disorder. J Affect Disord 1995, 35:31-40. The finding of an earlier age of onset in the offspring of parents with unipolar illness suggests the phenomenon of anticipation. In Huntingdon's disease, myotonic dystrophy and a handful of other conditions, this is attributed to a trinucleotide repeat expansion mechanism. This group suggests a similar mechanism may be operating in unipolar illness which, if true, would greatly aid the search for determinant or risk genes.
43. McMahon FJ, Stine OC, Meyers DA, Simpson SG, Depaulo JR: Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet 1995, 56:1277-1286.
44. Lander E, Kruglyak L: Genetic dissection of complex traits - guide-lines for interpreting and reporting linkage results. Nature Genet 1995, 11:241 247.
45. Lim L, Craddock N, Owen M, Sham P, Nothen M, Komer J, Rietschel M, Fimmer R, Propping P, McGuffin P et al.: Assessing the statistical power to detect linkage in a sample of 51 bipolar affective disorder pedigrees. Behav Genet 1996, 26:113 122. A number of the studies reviewed are based on the same 51 families used in this study. The authors show that such studies have little power, particularly if affective disorders are heterogeneous at the genetic level.