Oral tolerance in experimental animals

International Archives of Allergy and Immunology

Volumn 113, Issue 1-3, 1997, Pages 219-223

  Telemo, Esbjörn ^a   Karlsson, Malin ^a   Dahlman Höglund, Anna ^a   Dahlgren, Ulf ^a   Lundin, Samuel ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Experimental animals; Immune regulation; Oral tolerance; Review

Indexed keywords

INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN PRESENTATION; CLONAL ANERGY; CONFERENCE PAPER; DENDRITIC CELL; EXPERIMENTAL ANIMAL; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LYMPH NODE; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE;

ADMINISTRATION, ORAL; ANIMALS; ANTIGEN PRESENTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNE TOLERANCE; INTESTINES; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES;

EID: 0030888451     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237552     Document Type: Article

References (42)

1. Hcmmings WA, Williams E: Transport of large breakdown products of dietary protein through the gut wall, Gut 1978:19:715-723.
2. Husby S, Jensenius JC, Svehag S-F: Passage of undegraded dietary antigen into the blood of healthy adults, Further characterization of the kinetics of uptake and size distribution of the antigen, Scand J Immunol 1986;24:447-455.
3. Tclcmo E, Bailey M, Miller BG, Stokes CR, Bourne FJ: Dietary antigen handling by mother and offspring, Scand J Immunol 1991:34:689-696.
4. Mayer L, Panja A, Li Y, Sidcn E, Pizzimcnti A, Gerardi F, Unique features of antigen presentation in the intestine, Ann NY AcadSci 1992;664:39-46.
5. Bland PW, Warren L: Antigen presentation by epithelial cells of the rat small intestine I, Kinetics, antigen specificity and blocking by anti-la antisera, Immunology 1986:58:1-7.
6. Liu LM, MacPherson GO: Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo, J Exp Med 1993:177: 1299-1307.
7. Liu LM, MacPherson GG: The role of dendritic cells in the uptake and presentation of oral antigens, Adv Exp Med Biol 1994;355:81-86.
8. Vega-Lopez M, Telemo E, Bailey M, Stevens K, Stokes CR: Immune cell distribution in the small intestine of the pig: Immunohistological evidence for an organised compartmentalisa-tion in the lamina propria, Vet Immunol Immu-nopathol 1993:37:49-60.
9. Ngan J, Kind L: Suppressor T-cclls for IgE and IgG in the Peyer's patches of mice made tolerant by oral administration of ovalbumin, J Immunol 1978;120:861-865.
10. Mattingly JA, Waksman B: Immunologic suppression after oral administration of antigen, I, Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration, J Immunol 1978:121:1878-1883.
11. Silverman G, Peri B, Fitch F, Rothbcrg R: Enter-ically induced regulation of systemic immune responses II, Suppression of proliferating T cells by a Lyt-1+, 2- T effector cell, J Immunol 1983:131:2656-2661.
12. Khoury SJ, Hancock WW, Weiner HL: Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downrcgulation of inflammatory cytokines and differential up-regulation of transforming growth factor beta, interleukin 4. and prostaglandin F, expression in the brain, J Exp Med 1992:176:1355-1364.
13. Miller A, al Sabbagh A, Santos LM, Das MP, Weiner HL: Epitopes of myelin basic protein that trigger TGF-beta release after oral toleriza-tion are distinct from cnccphalitogcnic epitopes and mediate epitope-driven bystander suppression, J Immunol 1993:151:7307-7315.
14. Miller A, Lidcr O, Roberts AB, Sporn MB, Weiner IIL: Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering, Proc Natl Acad Sci USA 1992:89:421-425.
15. McMenamin C, McKersey M, Kuhnlcin P, Hu-nig T, Holt PG: Gamma delta T cells down-reg-ulate primary IgE responses in rats to inhaled soluble protein antigens, J Immunol 1995:154: 4390-4394.
16. Miller A, Lider O, Weiner HL: Antigen-driven bystander suppression after oral administration ofantigens, J Exp Med 1991;174:791-798.
17. Dahlman-Hoglund A, Dahlgren U, Ahlstedt S, Hanson IA, Telemo E: Bystander suppression of the immune response to human scrum albumin in rats fed ovalbumin, Immunology 1995; 86:128-133.
18. Bland P, Warren L: Antigen presentation by epithelial cells of the rat small intestine II, Selective induction of suppressor T cells, Immunology 1986:58:9-14.
19. McMenamin C, Holt PG: The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (Ml 1C) class l-restricted CD8+ T cell-mediated but MHC class I l-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin F, production, J Exp Med 1993:178:889-899.
20. Chen Y, Inobe J, Weiner IIL: Induction of oral tolerance to myelin basic protein in CD8-de-pleted mice: Both C'D4+ and CD8+ cells mediate active suppression, J Immunol 1995:155: 910-916.
21. Garside P, Steel M, Worthcy EA, Satoskar A, Alexander J, Bluethmann H, Liew FY, Mowat AM: T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction, J Immunol 1995:154:5649-5655.
22. Garside P, Steel M, Liew FY, Mowat AM: CD4 but not CD8+ T cells are required for the induction of oral tolerance, Int Immunol 1995:7:501-504.
23. Modigliani Y, Bandeira A, Cutinho A: A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens, Immunol Rev 1996:149:155-174.
24. Taguchi O, Takahashi T: Administration of antiinterleukin-2 receptor alpha antibodies in vivo induces localized autoimmune disease, Eur J Immunol 1996:26:1608-1612.
25. Taguchi O, Kontani K, Ikeda II, Kezuka T, Takcuchi M, Takahashi T, Takahashi T: Tissue-specific suppressor T cells involved in self-tolerance are activated cxtrathymically by self-antigens, Immunology 1994;82:365-369.
26. Sakaguchi S, Sakaguchi N, Asano M, Itoli M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25), Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J Immunol 1995; 155:1151-1164.
27. Willcrford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW: lntcrleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment, Immunity 1995:3:521-530.
28. Liu LM, MacPherson GG: Rat intestinal dendritic cells: Immunostimulatory potency and phenotypic characterization, Immunology 1995:85:88-93.
29. Constant S, Sant'Angclo D, Pasqualini T, Taylor T, Levin D, Flavell R, Bottomly K: Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells, J Immunol 1995:154:4915-4923.
30. Friedman A, Weiner IIL: Induction ofanergy or active suppression following oral tolerance is determined by antigen dosage, Proc Natl Acad Sei USA 1994:91:6688-6692.
31. Gregcrson DS, Obritsch WF, Donoso LA: Oral tolerance in experimental autoimmune uveorc-tinitis: Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols, J Immunol 1993; 151:5751-5761.
32. Lundin SB, Dahlgren UIH, Hanson LÄ, Telemo E: Oral tolerisation leads to active suppression and bystander tolerance in old rats while ancrgy dominates in young rats, Scand J Immunol 1996:43:56-63.
33. Melamed D, Friedman A: Direct evidence for ancrgy in T lymphocytes tolerized by oral administration of ovalbumin, Eur J Immunol 1993:23:935-942.
34. Challacombe SJ, Tomasi T: Systemic tolerance of secretory immunity after oral immunisation, J Exp Med, 1980;152:1459-1472.
35. Strobel S, Ferguson A: Immune responses to fed protein antigens in mice, III, Systemic tolerance or priming is related to age at which antigen is first encountered, Pediatr Res 1984; 18:588-594.
36. Miller A, Lider O, Abramsky O, Weiner IIL: Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals, Eur J Immunol 1994; 24:1026-1032.
37. Hanson DG, Roy MJ, Green GM, Miller SD: Inhibition of orally-induced immune tolerance in mice by prcfceding an endopeptidasc inhibitor, Regul Immunol 1993:5:76-84.
38. Bruce MG, Ferguson A: The influence of intestinal processing on the immunogenicity and molecular size of absorbed, circulating ovalbumin in mice, Immunology 1986;59:295-300.
39. Bruce MG, Ferguson A: Oral tolerance to ovalbumin in mice: Studies of chemically modified and 'biologically filtered' antigen, Immunology 1936:57:627-630.
40. Karlsson M, Dahlgren U, Hanson L, Telemo E: Ontogeny of the immune system in the small intestine of rats, Abstr 8th International Congress of Mucosal Immunology, San Diego, Clin Immunol Immunopathol 1995;76:110.
41. Karlsson M, Dahlgren U, Hanson L, Telemo E, Lundin S: Early expression of TGF-ß and reduced enlargement of the draining lymph node after immunisation of orally tolcriscd rats, XXVI Meeting of the Scandinavian Society of Immunology, 1995. Scand J Immunol 1995:41: 625.
42. Dahlman-I löglund A, Dahlgren UI, Hansson L, Ahlstedt S, Telemo E: Different expression of IL2-receptoralpha-chain on a lamina propria T-ccll population in rats orally tolerized or sensitized to ovalbumin (OA) afler colonization with E, coll producing OA, Clin Exp Immunol 1996: 106:534-540