Ovarian cancer genomic instability correlates with p53 frameshift mutations

Cancer Research

Volumn 57, Issue 6, 1997, Pages 1047-1049

  Sood, Anil K ^a   Stalling, Jeffrey S ^a   Buller, Richard E ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA;

ARTICLE; CONTROLLED STUDY; DNA REPLICATION; FEMALE; FRAMESHIFT MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MISSENSE MUTATION; OPEN READING FRAME; OVARY CANCER; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

CARCINOMA; DNA MUTATIONAL ANALYSIS; DNA REPAIR; DNA, NEOPLASM; FEMALE; FRAMESHIFT MUTATION; GENES, P53; HUMANS; MICROSATELLITE REPEATS; OPEN READING FRAMES; OVARIAN NEOPLASMS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 0030888264     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Jego, N., Thomas, G., and Hamelin, R. Short direct repeats flanking deletions and duplicating insertions in p53 gene in human cancers. Oncogene, 8: 209-213, 1993.
2. Shilling, J. S., Sood, A. K., Niemann, T., Lager, D. J., and Buller, R. E. An abundance of p53 null mutations in ovarian carcinoma. Oncogene, 13: 117-123, 1996.
3. Greenblatt, M. S., Grollman, A. P., and Harris, C. C. Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. Cancer Res., 56: 2130-2136, 1996.
4. Sood, A. K., and Buller, R. E. Genomic instability in ovarian cancer: a reassessment using arbitrarily primed polymerase chain reaction. Oncogene, 13: 2499-2504, 1996.
5. Buller, R. E., Stalling, J. S., Kaliszewski, S., Niemann, T., and Anderson, B. Absence of significant germ line p53 mutations in ovarian cancer patients. Gynecol. Oncol., 58: 368-374, 1995.
6. Strickler, J. G., Zheng, J., Shu, Q., Burgart, L. J., Alberts, S. R., and Shibata, D. p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail. Cancer Res., 54: 4750-4755, 1994.
7. n DNA repeats and tumor suppressor genes in human gastric cancer. Cancer Res., 54: 41-44, 1994.
8. Lane, D. P. p53, guardian of the genome. Nature (Lond.), 358: 15-16, 1992.
9. Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J-M., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G., Bohr, V. A., Weeda, G., Hoeijmakers, J. H. J., Forrester, K., and Harris, C. C. p53 modulation of TFIIH-associated nucleotide excision repair activity. Nat. Genet., 10: 188-195, 1995.
10. Loeb, L. A. Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res., 54: 5059-5063, 1994.
11. Peltomaki, P., Aaltonen, L. A., Sistonen, P., Pylkkanen, L., Mecklin, J. P., Jarvinen, H., Green, J. S., Jass, J. R., Weber, J. L., Leach, F. S., Petersen, G. M., Hamilton. S. R., de la Chapelle, A., and Vogelstein, B. Genetic mapping of a locus predisposing to human colorectal cancer. Science (Washington DC), 260: 810-812, 1993.
12. Aaltonen, L. A., Peltomaki, P., Leach, F. S., Sistonen, P., Pylkkanen, L., Mecklin, J. P., Jarvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., Petersen, G. M., Kinzler, K. W., Vogelstein, B., and de la Chapelle, A. Clues to the pathogenesis of familial colorectal cancer. Science (Washington DC), 260: 812-816, 1993.
13. Lewis, C. M., Neuhausen, S. L., Daley, D., Black, F. J., Swensen, J., Burt, R. W., Cannon-Albright, L. A., and Skolnick, M. H. Genetic heterogeneity and unmapped genes for colorectal cancer. Cancer Res., 56: 1382-1388, 1996.
14. Eshleman, J. R., Markowitz, S. D., Donover, P. S., Lang, E. Z., Lutterbaugh, J. D., Li, G-M., Longley, M., Modrich, P., Veigl, M. L., and Sedwick, W. D. Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability. Oncogene, 12: 1425-1432, 1996.
15. Huang, J., Papadopoulos, N., McKinley, A. J., Farrington, S. M., Curtis, L. J., Wyllie, A. H., Zheng, S., Willson, J. K. V., Markowitz, S. D., Morin, P., Kinzler, K. W., Vogelstein, B., and Dunlop, M. G. APC mutations in colorectal tumors with mismatch repair deficiency. Proc. Natl. Acad. Sci. USA, 93: 9049-9054, 1996.