Glucocorticoids use a positive liver element to repress fibrate-induced adipose transcription of the phosphoenolpyruvate carboxykinase gene

Molecular and Cellular Endocrinology

Volumn 127, Issue 2, 1997, Pages 171-177

  Franckhauser Vogel, Sylvie ^a   Glorian, Martine ^a   Forest, Claude ^a  

^a CNRS   (France)

Author keywords

Adipocytes; Fibrates; Glucocorticoids; Phosphoenolpyruvate carboxykinase; Response elements

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; CLOFIBRATE; DEXAMETHASONE; DNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; ISOPRENALINE; MESSENGER RNA; MIFEPRISTONE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DNA TRANSFECTION; GENE MUTATION; GENE REPRESSION; HEPATOMA CELL; HORMONAL REGULATION; HORMONE RESPONSIVE ELEMENT; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REPORTER GENE; TRANSCRIPTION REGULATION;

3T3 CELLS; ADIPOCYTES; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTILIPEMIC AGENTS; CELL EXTRACTS; CLOFIBRATE; DEXAMETHASONE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOCORTICOIDS; ISOPROTERENOL; LIVER; MICE; MIFEPRISTONE; MUTATION; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; TRANS-ACTIVATION (GENETICS);

EID: 0030888169     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(96)04006-3     Document Type: Article

References (42)

1. Nitsch, D., Boshart, M. and Schütz, G. (1993) Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements. Proc. Natl. Acad. Sci. USA 90, 5479-5483.
2. Imai, E., Stromstedt, P.E., Quinn, P.G., Carlstedt-Duke, J., Gustafsson, J.A. and Granner, D.K. (1990) Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 10, 4712-4719.
3. Diamond, M.I., Miner, J.N., Yoshinaga, S.K. and Yamamoto, K.R. (1990) Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249, 1266-1272.
4. Chatterjee, V.K.K., Madison, L.D., Mayo, S. and Jameson, J.L. (1991) Repression of the human glycocoprotein hormone α-subunit gene by glucocorticoids: evidence for receptor interactions with limiting transcriptional activators. Mol. Endocrinol. 5, 100-110.
5. Jonat, C., Rahmsdorf, H.J., Park, K., Cato, A.C.B., Gebel, S., Ponta, H. and Herrlich, P. (1990) Antitumor promotion and antiinflammation: down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 62, 1189-1204.
6. Imai, E., Miner, J.N., Mitchell, J.A., Yamamoto, K.R. and Granner, D.K. (1993) Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids. J. Biol. Chem. 268, 5353-5356.
7. Xing, L. and Quinn, P.G. (1993) Involvement of 3', 5'-cyclic adenosine monophosphate regulatory element binding protein (CREB) in both basal and hormone-mediated expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene. Mol. Endocrinol. 7, 1484-1494.
8. Lucas, P.C., O'Brien, R.M., Mitchell, J.A., Davis, C.M., Imai, E., Forman, B.M., Samuels, H.H. and Granner, D.K. (1991) A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene. Proc. Natl. Acad. Sci. USA 88, 2184-2188.
9. Hall, R.K., Scott, D.K., Noisin, E.L., Lucas, P.C. and Granner, D.K. (1992) Activation of the phosphoenolpyruvate carboxykinase gene retinoic acid response element is dependent on a retinoic acid receptor/coregulator complex. Mol. Cell. Biol. 12, 5527-5535.
10. Hall, R.K., Sladek, F.M. and Granner, D.K. (1995) The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Proc. Natl. Acad. Sci. USA 92, 412-416.
11. Meyuhas, O., Reshef, L., Gunn, J. M., Hanson, R.W. and Ballard, F.J. (1976) Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin. Biochem. J. 158, 1-7.
12. Nechushtan, H., Benvenisty, N., Brandeis, R. and Reshef, L. (1987) Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner. Nucleic Acids Res. 15, 6405-6417.
13. Franckhauser, S., Antras-Ferry, J., Robin, P., Robin, D., Granner, D.K. and Forest, C. (1995) Expression of the phosphoenolpyruvate carboxykinase gene in 3T3-F442A adipose cells: opposite effects of dexamethasone and isoprenaline on transcription. Biochem. J. 305, 65-71.
14. Antras-Ferry, J., Franckhauser, S., Robin, D., Robin, P., Granner, D.K. and Forest, C. (1994) Expression of the phosphoenolpyruvate carboxykinase gene in 3T3-F442A adipose cells: effects of retinoic acid and differentiation. Biochem. J. 302, 943-948.
15. Franckhauser, S., Antras-Ferry, J., Robin, P., Robin, D. and Forest, C. (1994) Glucocorticoids antagonize retinoic acid stimulation of PEPCK gene transcription in 3T3-F442A adipocytes. Cell. Mol. Biol. 40, 723-729.
16. Antras-Ferry, J., Le Bigot, G., Robin, P., Robin, D. and Forest, C. (1994) Stimulation of phosphoenolpyruvate carboxykinase gene expression by fatty acids. Biochem. Biophys. Res. Commun. 203, 385-391.
17. Antras-Ferry, J., Robin, P., Robin, D. and Forest, C. (1995) Fatty acids and fibrates are potent inducers of transcription of the phosphoenolpyruvate carboxykinase gene in adipocytes. Eur. J. Biochem. 234, 390-396.
18. Wahli, W., Braissant, O. and Desvergne, B. (1995) Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more... Chem. Biol. 2, 261-266.
19. Tontonoz, P., Hu,E., Devine, J., Beale, E.G. and Spiegelman, B.M. (1995) PPARγ 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 15, 351-357.
20. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann. Biochem. 162, 156-159.
21. Beale, E.G., Chrapkiewicz, N.B., Scoble, H.A., Metz, R.J., Quick, D.P., Noble, R.L., Donelson, J.E., Biemann, K. and Granner, D.K. (1985) Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). J. Biol. Chem. 260, 10748-10760.
22. Gorski, K., Carneiro, M. and Schibler, U. (1986) Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47, 767-776.
23. Shapiro, D.J., Sharp, P.A., Wahli, W.W. and Keller, M.J. (1988) A high-efficiency HeLa cell nuclear transcription extract. DNA 7, 47-55.
24. Picard, V., Ersdal-Badju, E., Lu, A. and Clark Bock, S. (1994) A rapid and efficient one-tube PCR-based mutagenesis technique using Pfu DNA polymerase. Nucleic Acids Res. 22, 2587-2591.
25. Magnuson, M.A., Quinn, P.G. and Granner, D.K. (1987) Multihormonal regulation of phosphoenolpyruvate carboxykinasechloramphenicol acetyltransferase fusion genes. J. Biol. Chem. 262, 14917-14920.
26. MacDougald, O.A., Cornelius, P., Lin, F.T., Chen, S.S. and Lane, M.D. (1994) Glucocorticoids reciprocally regulate expression of the CCAAT/Enhancer-binding protein α and δ genes in 3T3-L1 adipocytes and white adipose tissue. J. Biol. Chem. 269, 19041-19047.
27. Park, E.A., Roesler, W.J., Liu, J., Klemm, D.J., Gurney, A.L., Thatcher, J.D., Shuman, J., Friedman, A. and Hanson, R.W. (1990) The role of the CCAAT/Enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). Mol. Cell. Biol. 10, 6264-6272.
28. Park, E.A., Gurney A.L., Nizielski, Hakimi, P., Cao, Z., Moorman, A. and Hanson R.W. (1993) Relative roles of CCAAT/Enhancer-binding protein β and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP). J. Biol. Chem. 268, 613-619.
29. Liu, J., Park, E.A., Gurney, A.L., Roesler, W.J. and Hanson, R.W. (1991) Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements. J. Biol. Chem. 266, 19095-19102.
30. Roesler, W.J., Vandenbark, G.R., and Hanson, R.W. (1989) Identification of multiple protein binding domains in the promoter-regulatory region of the phosphoenolpyruvate carboxykinase (GTP) gene. J. Biol. Chem. 264, 9657-9664.
31. Gurney, A.L., Park, E.A., Giralt, M., Liu, J. and Hanson, R.W. (1992) Opposing actions of fos and jun on transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. J. Biol. Chem. 267, 18133-18139.
32. Quinn, P.G., Wong, T.W., Magnuson, M.A., Shabb, J.B. and Granner, D.K. (1988) Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Mol. Cell. Biol. 8, 3467-3475.
33. Guardiola-Diaz, H.M., Kolinske, J.S., Gates, L.H. and Seasholtz, A.F. (1996) Negative glucocorticoid regulation of cyclic adenosine 3',5'-monophosphate-stimulated corticotropin-releasing hormone-reporter expression in AtT-20 cells. Mol. Endocrinol. 10, 317-329.
34. Cooney, A.J., Leng, X., Tsai, S.Y., O' Malley, B.W. and Tsai, M.J. (1993) Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. J. Biol. Chem. 268, 4152-4160.
35. Kliewer, S.A., Umesono, K., Noonan, D.J., Heyman, R.A. and Evans, R.M. (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358, 771-774.
36. Willy, P.J., Umesono, K., Ong, E.S., Evans, R.M., Heyman, R.A. and Mangelsdorf, D.J. (1995) LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev. 9, 1033-1045.
37. Miyata, K.S., McCaw, S.E., Patel, H.V., Rachubinski, R.A. and Capone, J.P. (1996) The orphan nuclear hormone receptor LXRa interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling. J. Biol. Chem. 271, 9189-9192.
38. Mangelsdorf, D.J. and Evans, R.M. (1995) The RXR heterodimers and orphan receptors. Cell 83, 841-850.
39. Katzenellenbogen, J.A., O' Malley, B.W. and Katzenellenbogen, B.S. (1996) Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter- specific action of these hormones. Mol. Endocrinol. 10, 119-131.
40. Chen, J.D., Umesono, K. and Evans, R.M. (1996) SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. Proc. Natl. Acad. Sci. USA 93, 7567-7571.
41. Chakravarti, D., LaMorte, V.J., Nelson, M.C., Nakajima, T., Schulman, I.G., Juguilon, H., Montminy, M. and Evans, R.M. (1996) Role of CBP/P300 in nuclear receptor signalling. Nature 383, 99-102.
42. O'Brien, R.M., Lucas, P.C., Forest, C.D., Magnuson, M.A., and Granner, D.K. (1990) Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science 249, 533-537.