Protein from chromaffin granules promotes survival of mesencephalic dopaminergic neurons by an EGF-receptor ligand-mediated mechanism

Journal of Neuroscience Research

Volumn 48, Issue 1, 1997, Pages 18-30

  Krieglstein, Kerstin ^a   Unsicker, Klaus ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

adrenal medulla; neurotrophic factor; nigrostriatal system; Parkinson's disease

Indexed keywords

CELL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CHROMAFFIN GRANULE; CULTURE MEDIUM; DOPAMINERGIC NERVE CELL; IMMUNOCYTOCHEMISTRY; MESENCEPHALON; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

1-METHYL-4-PHENYLPYRIDINIUM; ADRENAL GLANDS; ANIMALS; ASTROCYTES; CARBACHOL; CATTLE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; CHROMAFFIN CELLS; CHROMAFFIN GRANULES; DOPAMINE; DOPAMINE AGENTS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; LIGANDS; MESENCEPHALON; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; NEUROPEPTIDES; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PARASYMPATHOMIMETICS; PROTEINS; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 0030887141     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19970401)48:1<18::AID-JNR2>3.0.CO;2-H     Document Type: Article

References (47)

1. Alexi T, Hefti F (1993): Trophic actions of transforming growth factor α on mesencephalic dopmainergic neurons developing in culture. Neuroscience 55:903-918.
2. Becker JB, Freed WJ (1988): Adrenal medulla grafts enhance functional activity of the striatal dopamine system following substantia nigra lesions. Brain Res 462:401-406.
3. Bieger SC, Henkel A, Unsicker K (1995): Localization of basic fibroblast growth factor in bovine adrenal chromaffin cells. J Neurochem 64:1521-1527.
4. Blöchl A, Thoenen H (1995): Characterization of nerve growth factor (NGF) release from hippocampal neurons: Evidence for a constitutive and an unconventional sodium-dependent regulated pathway. Eur J Neurosci 7:1220-1228.
5. Bohn MC, Marciano F, Cupit L, Gash DM (1987): Adrenal medullary grafts promote recovery of striatal dopaminergic fibers in MPTP treated mice. Science 237:913-916.
6. Buchdunger E, Trinks U, Mett H, Regenass U, Müller M, Meyer T, McGlynn E, Pinna LA, Traxler P, Lydon NB (1994): 4,5-Dianilinophthalimide: A protein-tyrosine kinase inhibitor with selectivity for epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc Natl Acad Sci U S A 91:2334.
7. Carpenter G, Wahl MI (1990): The epidermal growth factor family. In Sporn MB, Roberts AB (eds): "Peptide Growth Factors and Their Receptors." Springer Verlag, Heidelberg, pp 69-171.
8. Casper D, Mytilineou C, Blum M (1991): EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture. J Neurosci Res 30:372-381.
9. Coulter CL, McMillen IC, Browne CA (1988): The catecholamine content of the perinatal rat adrenal gland. Gen Pharmacol 19:825-828.
10. Ehringer H, Hornykiewicz O (1960): Verteilung von Noradrenalin und Dopamin (3-Hydroxytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des extrapyramidalen Systems. Klin Wschr 38:1236-1239.
11. Engele J, Bohn MC (1991): The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia. J Neurosci 11:3070-3078.
12. Engele J, Rieck H, Choi-Lundberg D, Bohn MC (1996): Evidence for a novel neurotrophic factor for dopaminergic neurons secreted from mesencephalic glial cell lines. J Neurosci Res 43:576-586.
13. Ferrari G, Minozzi M-C, Toffano G, Leon A, Skaper AD (1989): Basic fibroblast growth factor promotes the survival and development of mesencephalic neurons in culture. Dev Biol 133:140-147.
14. Fisher LJ, Gage FH (1993): Grafting in the mammalian central nervous system. Physiol Rev 73:583-616.
15. Freed WJ (1993): Neural transplantation: Prospects for clinical use. Cell Transplant 2:13-31.
16. Gazit A, Yaissh P, Gilson C, Levittzki A (1989): Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32:2344-2352.
17. Goodman LJ, Hefti F (1994): Regulation and polarity of neurotrophin secretion. Soc Neurosci Abstr 20:1303.
18. Hansen JT, Kordower JH, Fiandaca MS, Jiao S-S, Notter MFD, Gash DM (1988): Adrenal medullary autografts into the basal ganglia of cebus monkeys: Graft viability and fine structure. Exp Neurol 102:65-75
19. Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M (1991): A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science 251:936-939.
20. Jousselin-Hosaja M, Derbin C, Brisorgueil M-J, Rioux F (1994): Morphology and immunohistochemistry of the nerve endings on the chromaffin cells of adrenal medulla grafted into mouse brain. Dev Brain Res 79:321-327.
21. Kimura H, Fischer WH, Schubert D (1990): Structure, expression and function of a Schwannoma-derived growth factor. Nature 348: 257-260.
22. Knusel B, Michel PP, Schwaber JS, Hefti F (1990): Selective and nonselective stimulation of cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. J Neurosci 10:558-570.
23. Kopin IJ, Markey SP (1988): MPTP toxicity: Implications for research in Parkinson's disease. Annu Rev Neurosci 11:81-96.
24. Kordower JH, Cochran E, Penn RD, Goetz CG (1991): Putative chromaffin cell survival and enhanced host-derived TH-fiber innervation following a functional adrenal medulla autograft for Parkinson's disease. Ann Neurol 29:405-412.
25. Krieglstein K, Unsicker K (1994): Transforming growth factor-β promotes survival of midrain dopaminergic neurons and protects them against N-methyl-4-phenylpyridinium ion toxicity. Neuroscience 63:1189-1196.
26. Lachmund A, Gehrke D, Krieglstein K, Unsicker K (1994): Trophic factors from chromaffin granules promote survival of peripheral and central nervous system neurons. Neuroscience 62:361-370.
27. Lee DC, Fenton SE, Berkowitz EA, Hissong MA (1995a): Transforming growth factor α: Expression, regulation, and biological activities. Pharmacol Rev 47:51-85.
28. Lee YL, Helman L, Hoffman T, Laborda J (1995b): dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA. Biochim Biophys Acta 1261:223-232.
29. Lin LFH, Doherty DH, Lile JD, Bektesh S, Collins F (1993): GDNF - A glial cell line derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132.
30. Marchionni MA, Goodearl ADJ, Chen MS, Beermingham-McDonogh O, Cassandra K, Hendricks M, Daheny F, Misumi D, Sudhalter J, Kobayashi K, Wroblewski D, Lynch C, Baldassare M, Hiles I, Davis JB, Hsuan JJ, Totty NF (1993): Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362:312-318.
31. O'Malley EK, Sieber B-A, Morrison RS, Black IB, Dreyfus CF (1994): Nigral type I astrocytes release a soluble factor that increases dopaminergic neuron survival through mechanisms distinct from basic fibroblast growth factor. Brain Res 647:83-90.
32. Ortega JD, Sagen J, Pappas GD (1992): Survival and integration of bovine chromaffin cells transplanted into rat central nervous system without exogenous trophic factors. J Comp Neurol 323:13-24.
33. Otto D, Unsicker K (1993a): FGF-2 modulates dopamine and dopamine-related striatal transmitter systems in the intact and MPTP-lesioned mouse. Eur J Neurosci 5:927-932.
34. Otto D, Unsicker K (1993b): FGF-2-mediated protection of cultured mesencephalic dopaminergic neurons against MPTP and MPP+: Specificty and impact of culture conditions, non-dopaminergic neurons, and astroglial cells. J Neurosci Res 34:382-393.
35. Otto D, Unsicker K (1990): Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice. J Neurosci 10:1912-1921.
36. Schaar DG, Sieber B-A, Dreyfus CF, Black IB (1993): Regional and cell-specific expression of GDNF in rat brain. Exp Neural 124:368-371.
37. Shing Y, Christofori G, Hanahan D, Ono Y, Sasada R, Igarashi K, Folkman J (1993): Betacellulin: A mitogen from pancreatic β cell tumors. Science 259:1604-1607.
38. Shoyab M, Plowman GD, McDonald VL, Bradley JG, Todaro GJ (1989): Structure and function of human amphiregulin: A member of the epidermal growth factor family. Science 243: 1074-1076.
39. Stachowiak MK, Moffett J, Joy A, Puchacz E, Florkiewicz R, Stachowiak EK (1994): Regulation of bFGF gene expression and subcellular distribution of bFGF protein in adrenal medullary cells. J Cell Biol 127:203-223.
40. Takeshima T, Johnston JM, Commissiong JW (1994): Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation. J Neurosci 14:4769-4779.
41. Toyoda H, Komurasaki T, Uchida D, Takayama Y, Isobe T, Okuyama T, Hanada K (1995): Epiregulin: A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. J Biol Chem 270:7495-7500.
42. Unsicker K, Krieglstein K (1996): Growth factors in chromaffin cells. Prog Neurobiol 48:307-324.
43. Unsicker K, Stögbauer F (1992): Screening ot medullary neuropeptides for putative neurotrophic effects. Int J Devl Neuroscience 10:171-179.
44. Unsicker K, Suter-Crazzolara C, Krieglstein K (1996): Functions of growth facgtors in the development and maintenance of midbrain dopaminergic neurons: Concepts, facts, and prospects of the transforming growth factors β. In: "Growth Factors as Drugs for Neurological and Sensory Disorders." CIBA Foundation Symposium #196. Chichester, UK: Wiley, pp 70-84.
45. Unsicker K, Griesser GH, Lindmar R, Löffelholz U, Wolf U (1980): Establishment, characterization and fibre outgrowth of isolated bovine adrenal medullary cells in long-term cultures. Neuroscience 5:1445-1460.
46. Winkler H, Apps DK, Fischer-Colbrie R (1986): The molecular function of adrenal chromaffin granules: Established facts and unresolved topics. Neuroscience 18:261-290.
47. Winkler H, Smith AD (1975): The chromaffin granule and the storage of catecholamines. In Blaschko H, Smith AD, Sayers G (eds): "Handbook of Physiology Section 7," Vol 6, pp 321-339.