Different susceptibility of three clinically isolated strains of Cryptococcus neoformans to the fungicidal effects of reactive nitrogen and oxygen intermediates: Possible relationships with virulence

Microbiology and Immunology

Volumn 41, Issue 9, 1997, Pages 725-731

  Xie, Qifeng ^a,b   Kawakami, Kazuyoshi ^a   Kudeken, Norifumi ^a   Zhang, Tiantuo ^a,b   Qureshi, Mahboob Hossain ^a   Saito, Atsushi ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cryptococcus neoformans; Nitric oxide; Superoxide; Virulence

Indexed keywords

NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATION; CELL FREE SYSTEM; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; FEMALE; FUNGICIDAL ACTIVITY; MACROPHAGE; MOUSE; MYCOSIS; NONHUMAN; VIRULENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); FILOBASIDIELLA NEOFORMANS;

EID: 0030886927     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.1997.tb01917.x     Document Type: Article

References (34)

1. Adams, L.B., Franzblau, S.G., Vavrin, Z., Hibbs, J.B., Jr., and Krahenbuhl, J.L. 1991. L-arginine-dependent macrophage effector functions inhibit metabolic activity of Mycobacterium leprae. J. Immunol. 147: 1642-1646.
2. Alspaugh, J.A., and Granger, D.L. 1991. Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis. Infect. Immun. 59: 2291-2296.
3. Brummer, E., and Stevens, D. 1994. Anticryptococcal activity of macrophages: role of mouse strain, C5, contact, and L-arginine. Cell. Immunol. 157: 1-10.
4. Denis, M. 1991. Interferon-gamma-treated macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates. Cell. Immunol. 132: 150-157.
5. Furchgott, R.F., and Zawadzki, J. V. 1980. The obligatory role of endothelial cells in the relaxation of arterial muscle by acetylcholine. Nature 288: 373-376.
6. Furchgott, R.F. 1983. Role of endothelium in responses of vascular smooth muscle. Cir. Res. 53: 557-573.
7. Gazinelli, R.T., Oswald, I.P., Hieny, S., James, S.L., and Sher, A. 1992. The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta. Eur. J. Immunol. 22: 2501-2506.
8. Granger, D.L., Hibbs, J.B., Jr., Prefect, J.R., and Durack, D.T. 1990. Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. J. Clin. Invest. 85: 264-267.
9. Hibbs, J., Jr., Taintor, R.R., and Vavrin, Z. 1987. Macrophage cytotoxicity: role for L-arginine deaminase and imino nitrogen oxidation to nitrite. Science 235: 473-476.
10. Hibbs, J.B., Vavrin, Z., and Taintor, R.R. 1987. L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells. J. Immunol. 138: 550-562.
11. Huffnagle, G.B., Yates, J.L., and Lipscome, M.F. 1991. T cell-mediated immunity in the lung: a Cryptococcus neoformans pulmonary infection model using SCID and athymic nude mice. Infect. Immun. 59: 1423-1433.
12. Iyengar, R., Stuehr, D., and Maletta, J. 1987. Macrophage synthesis of nitrite, nitrate and N-nitrosamines: precursors and role of the respiratory burst. Proc. Natl. Acad. Sci. U.S.A. 84: 6369-6373.
13. Jacobson, E.S., and Tinnell, S.B. 1993. Antioxidant function of fungal melanin. J. Bacteriol. 175: 7102-7104.
14. James, S.L., and Glaven, J. 1989. Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates. J. Immunol. 143: 4208-4212.
15. Kagaya, K., Yamada, T., Miyakawa, Y., Fukazawa, Y., and Saito, S. 1985. Characterization of pathogenic constituents of Cryptococcus neoformans strains. Microbiol. Immunol. 29: 517-532.
16. Kawakami, K., Kohno, S., Morikawa, N., Kadota, J., Saito, A., and Hara, K. 1994. Activation of macrophages and expansion of specific T lymphocytes in the lungs of mice intratracheally inoculated with Cryptococcus neoformans. Clin. Exp. Immunol. 96: 230-237.
17. Kawakami, K., Tohyama, M., Teruya, K., Kudeken, N., Xie, Q., and Saito, A. 1996. Contribution of interferon-γ in protecting mice during pulmonary and disseminated infection with Cryptococcus neoformans. FEMS Immunol. Med. Microbiol. 13: 123-130.
18. Kawakami, K., Tohyama, M., Qifeng, X., and Saito, A. 1997. Expression of cytokines and inducible nitric oxide synthase mRNA in the lungs of mice infected with Cryptococcus neoformans: effects of interleukin-12. Infect. Immun. 65: 1307-1312.
19. Kozel, T.R., and Cazin, J., Jr. 1971. Nonencapsulated variant of Cryptococcus neoformans. I. Virulence studies and characterization of soluble polysaccharide. Infect. Immun. 3: 287-294.
20. Kozel, T.R., Pfrommer, S.T., Cuerlain, A.S., Highison, B.A., and Highison, G.J. 1988. Role of the capsule in phagocytosis of Cryptococcus neoformans. Rev. Infect. Dis. 10: S436-439.
21. Kwon-Chang, K.J., and Rhodes, J.C. 1986. Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. Infect. Immun. 51: 218-223.
22. Langermans, J.A.M., van der Hulst, M.E.B., Nibbering, P.H., et al. 1992. IFN-γ-induced L-arginine-dependent toxoplasmatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-α. J. Immunol. 148: 568-574.
23. Liew, F.Y., Millott, S., Parkinson, C., Palmer, R.M.J., and Moncada, S. 1990. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J. Immunol. 144: 4794-4797.
24. Liew, F.Y., and Cox, F.E.G. 1991. Nonspecific defense mechanism: the role of nitric oxide. Immunol. Today 12: A17-21.
25. Nakagawara, A., and Minakami, S. 1975. Generation of superoxide anions by leukocytes treated with cytochalasin E. Biochem. Biophys. Res. Commun. 64: 760-767.
26. Palmer, R.M.J., Ferrige, A.G., and Moncada, S. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526.
27. Polacheck, I., Platt, Y., and Aronovitch, J. 1990. Catecholamines and virulence of Cryptococcus neoformans. Infect. Immun. 58: 2919-2922.
28. Rhodes, J.C., Polacheck, I., and Kwong-Chung, K.J. 1982. Phenoloxidase activity and virulence in isogenic strains of Cryptococcus neoformans. Infect. Immunol. 36: 1175-1184.
29. Stevens, D.A. 1990. Fungal infections in AIDS patients. Br. J. Clin. Practice 44 (Suppl. 1): 11-22.
30. Tohyama, M., Kawakami, K., Futenma, M., and Saito, A. 1996. Enhancing effect of oxygen radical scavengers on murine macrophage anticryptococcal activity through production of nitric oxide. Clin. Exp. Immunol. 103: 436-441.
31. Walker, L., and Lowries, D.B. 1981. Killing of Mycobacterium microti by immunologically activated macrophages. Nature 293: 69-71.
32. Wang, Y., and Casadevall, A. 1994. Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen-and oxygen-derived oxidants. Infect. Immun. 62: 3004-3007.
33. Wheeler, M.H., and Bell, A.A. 1988. Melanins and their importance in pathogenic fungi. Curr. Top. Med. Mycol. 2: 338-387.
34. Yasuoka, A., Kohno, S., Yamada, H., Kaku, M., and Koga, H. 1994. Influence of molecular sizes of Cryptococcus neoformans capsular polysaccharide on phagocytosis. Microbiol. Immunol. 38: 851-856.