Ricin fusion toxin targeted to the human granulocyte-macrophage colony stimulating factor receptor is selectively toxic to acute myeloid leukemia cells

Leukemia Research

Volumn 21, Issue 7, 1997, Pages 681-690

  Burbage, Chris ^a   Tagge, Edward P ^a   Harris, Billie ^a   Hall, Philip ^b   Fu, Tao ^a   Willingham, Mark C ^a   Frankel, Arthur E ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

GMCSF receptor; Myeloid leukemia cells; Ricin

Indexed keywords

COLONY STIMULATING FACTOR RECEPTOR; GLYCOPROTEIN P; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; PROTEIN ANTIBODY; PROTEIN BCL 2; RICIN;

ACUTE GRANULOCYTIC LEUKEMIA; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNOAFFINITY CHROMATOGRAPHY; LEPIDOPTERA; LEUKEMIA CELL; MOLECULAR WEIGHT; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN SYNTHESIS INHIBITION; RECEPTOR BINDING;

ALPHA-FETOPROTEINS; ANIMALS; ANTIBODIES; ASIALOGLYCOPROTEINS; BCL-X PROTEIN; BINDING, COMPETITIVE; CELL LINE; CELL SURVIVAL; DRUG RESISTANCE, MULTIPLE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HL-60 CELLS; HUMANS; KINETICS; LEUKEMIA, MYELOCYTIC, ACUTE; MOLECULAR WEIGHT; P-GLYCOPROTEIN; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECOMBINANT FUSION PROTEINS; RICIN; SPODOPTERA; TUMOR CELLS, CULTURED;

EID: 0030886711     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(97)00043-X     Document Type: Article

References (37)

1. Bennet, J., Catovsky, D., Daniel, M., Flandrin, G., Galton, G., Galton, D., Gralnick, H. and Sultan, C., Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Annals of Internal Medicine, 1985, 103, 626.
2. List, A., Role of multidrug resistance and its pharmacological modulation in acute myeloid leukemia. Leukemia, 1996, 10, 937.
3. Frankel, A., Tagge, E. and Willingham, M., Clinical trials of targeted toxins. Seminars in Cancer Biology, 1995, 6, 307-317.
4. Xu, Y., Xu, Q., Rosenblum, M. and Scheinberg, D., Antileukemic activity of recombinant humanized M195-gelonin immunotoxin in nude mice. Leukemia, 1996, 10, 321.
5. La Russa, V., Griffin, J., Kessler, S., Cutting, M., Knight, R., Blattler, W., Lambert, J. and Wright, D., Effects of anti-CD33 blocked ricin immunotoxin on the capacity of CD34+ human marrow cells to establish in vitro hematopoiesis in long-term marrow cultures. Experimental Hematology, 1992, 20, 442.
6. Bendel, A., Shao, Y., Davies, S., Warman, B., Yang, C., Waddick, K., Uckun, F. and Perentesis, J., A recombinant fusion toxin targeted to the granulocyte-macrophage colony-stimulating factor receptor. Leukemia and Lymphoma, in press.
7. Olsnes, S. and Pihl, A., Different biological properties of the two constituent peptide chains of ricin, a toxic protein inhibiting protein synthesis. Biochemistry, 1973, 12, 3121.
8. Sandvig, K. and Olsnes, S., Entry of the toxic proteins abrin, modeccin, ricin and diphtheria toxin into cells. Journal of Biological Chemistry, 1982, 257, 7504.
9. Wales, R., Roberts, L. and Lord, J., Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells. Journal of Biological Chemistry, 1993, 268, 23986.
10. Endo, Y. and Tsurugi, K., RNA N-glycosidase activity of ricin A-chain. Journal of Biological Chemistry, 1987, 262, 8128.
11. Eiklid, K., Olsnes, S. and Pihl, A., Entry of lethal doses of abrin, ricin and modeccin into the cytosol of HeLa cells. Experimental Cell Research, 1980, 126, 321.
12. Kochi, S. and Collier, R., DNA fragmentation of cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis. Experimental Cell Research, 1993, 208, 296.
13. Frankel, A., Roberts, H., Afrin, L., Vesely, J. and Willingham, M., Expression of ricin B chain in Spodoptera frugiperda. Biochemistry Journal, 1994, 303, 787.
14. Frankel, A., Tagge, E., Chandler, J., Burbage, C., Hancock, G., Vesely, J. and Willingham, M., Characterization of single site ricin toxin B chain mutants. Bioconjugate Chemistry, 1996, 7, 30.
15. Frankel, A., Tagge, E., Chandler, J., Burbage, C. and Willingham, M., Double-site ricin B chain mutants retain galactose binding. Protein Engineering, 1996, 9, 371.
16. Fu, T., Burbage, C., Tagge, E., Chandler, J., Willingham, M. and Frankel, A., Double lectin-site ricin B chain mutants expressed in insect cells have residual galactose binding: evidence for more than two lectin sites on RTB. Bioconjugate Chemistry, 1996, 7, 651.
17. Frankel, A., Burbage, C., Fu, T., Tagge, E., Chandler, J. and Willingham, M., Ricin toxin contains at least three galactose-binding sites located in B chain subdomains 1α, 1β, and 2γ. Biochemistry, 1996, 35, 14747.
18. Afrin, L., Gulick, H., Vesely, J., Willingham, M. and Frankel, A., Expression of oligohistidine-tagged ricin B chain in Spodoptera frugiperda. Bioconjugate Chemistry, 1994, 5, 539.
19. Frankel, A., Tagge, E., Chandler, J., Burbage, C., Hancock, G., Vesely, J. and Willingham, M., IL2-ricin fusion toxin is selectively cytotoxic in vitro to IL2 receptor bearing tumor cells. Bioconjugate Chemistry, 1995, 6, 666.
20. Frankel, A. E., Burbage, C., Fu, T., Tagge, E. P., Chandler, J. C. and Willingham, M., Characterization of a ricin fusion toxin targeted to the interleukin-2 receptor. Protein Engineering, 1996, 9, 913.
21. Frankel, A., Fu, T., Burbage, C., Chandler, J., Willingham, M. and Tagge, E., IL2 fused to lectin deficient ricin is toxic to human leukemia cells expressing the IL2 receptor. Leukemia, 1997, 11, 22.
22. Frankel, A., Fu, T., Burbage, C., Tagge, E., Harris, B., Vesely, J. and Willingham, M., Lectin-deficient ricin toxin intoxicates cells bearing the D-mannose receptor. Carbon Research, 1997, 300, 251.
23. Sanger, F., Nicklen, S. and Coulson, A., DNA sequencing with chain-terminating inhibitors. Proceedings of the National Academy of Science of the U.S.A., 1977, 74, 5463.
24. Kreitman, R., Puri, R. and Pastan, I., A circularly permuted recombinant interleukin 4 toxin with increased activity. Proceedings of the National Academy of Science of the U.S.A., 1994, 91, 6889.
25. L overexpression inhibits taxol-induced Yama protease activity and apoptosis. Cell Growth and Differentiation, 1996, 7, 1087.
26. Bullock, G., Ray, S., Reed, J., Krajewski, S., Ibrado, A., Huang, Y. and Bhalla, K., Intracellular metabolism of ara-C and resulting DNA fragmentation and apoptosis of human AML HL-60 cells possessing disparate levels of Bcl-2 protein. Leukemia, in press.
27. Marquardt, D., McCrone, S. and Center, M., Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein. Cancer Research, 1990, 50, 1426.
28. Park, L., Waldron, P., Friend, D., Sassenfeld, H., Price, V., Anderson, D., Cosman, D., Andrews, R., Bernstein, I. and Urdal, D., Interleukin-3, GM-CSF and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. Blood, 1989, 74, 56.
29. Hertler, A., Schlossman, D., Borowitz, M., Blythman, H., Casellas, P. and Frankel, A., An anti-CD5 immunotoxin for chronic lymphocytic leukemia: enhancement of cytotoxicity with human serum albumin-monensin. International Journal of Cancer, 1989, 43, 215.
30. Tagge, E., Chandler, J., Tang, B., Hong, W., Willingham, M. and Frankel, A., Cytotoxicity of KDEL-terminated ricin toxins correlates with distribution of the KDEL receptor in the Golgi. Journal of Histochemistry and Cytochemistry, 1996, 44, 159.
31. McKinstry, W., Li, C., Rasko, J., Nicola, N., Johnson, G. and Metcalf, D., Cytokine receptor expression on hematopoietic stem and progenitor cells. Blood, 1997, 89, 65.
32. Park, L., Waldron, P., Friend, D., Sassenfeld, H., Price, V., Anderson, D., Cosman, D., Andrews, R., Bernstein, I. and Urdal, D., Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: receptor heterogeneity and relationship to growth factor responsiveness. Blood, 1989, 74, 56.
33. Walter, M., Cook, W., Ealick, S., Nagabhushan, T., Trotta, P. and Bugg, C., Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor. Journal of Molecular Biology, 1992, 224, 1075.
34. Goldmacher, V., Lambert, J. and Blattler, W., The specific cytotoxicity of immunoconjugates containing blocked ricin is dependent on the residual binding capacity of blocked ricin: evidence that the membrane binding and A-chain translocation activities of ricin cannot be separated. Biochemical and Biophysical Research Communications, 1992, 183, 758.
35. Newton, D., Wales, R., Richardson, P., Walbridge, S., Saxena, S., Ackerman, E., Roberts, L., Lord, J. and Youle, R., Cell surface and intracellular functions for ricin galactose binding. Journal of Biological Chemistry, 1992, 267, 11917.
36. Youle, R., Murray, G. and Neville, D., Studies on the galactose-binding site of ricin and the hybrid toxin Man6P-ricin. Cell, 1981, 23, 551.
37. Engert, A., Brown, A. and Thorpe, P., Resistance of myeloid leukaemia cell lines to ricin A-chain immunotoxins. Leukemia Research, 1991, 15, 1079.