Effects of nicotinamide on central cholinergic transmission and on spatial learning in rats

Pharmacology Biochemistry and Behavior

Volumn 53, Issue 4, 1996, Pages 783-790

  Köppen, Andrea ^a   Klein, Jochen ^a   Schmidt, Bernard H ^b   Van Der Staay, Franz Josef ^b   Löffelholz, Konrad ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b MEDA Manufacturing GmbH   (Germany)

Author keywords

Acetylcholine; Choline; Morris water maze; Nicotinamide

Indexed keywords

ACETYLCHOLINE; CHOLINE; NICOTINAMIDE; NOOTROPIC AGENT;

ACETYLCHOLINE RELEASE; AGE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN LEVEL; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DRUG POTENTIATION; EXTRACELLULAR SPACE; HIPPOCAMPUS; LEARNING; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; SPATIAL ORIENTATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0343463073     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02118-3     Document Type: Article

References (33)

1. Aquilonius, S. M.; Winbladh, B. Cerebrospinal fluid clearance of choline and some other amines. Acta Physiol. Scand. 85:78-90; 1972.
2. Bartus, R. T.; Dean, R. L.; Beer, B.; Lippa, A. S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-417; 1982.
3. Benveniste, H.; Hüttemeier, P. C. Microdialysis-theory and application. Prog. Neurobiol. 35:195-215; 1990.
4. 1 cholinergic agonist, AF102B. Pharmacol. Biochem. Behav. 36:89-95; 1990.
5. Court, J. A.; Perry, E. K. Dementia: The neurochemical basis of putative transmitter orientated therapy. Pharmacol. Ther. 52: 423-443; 1991.
6. Coyle, J. T.; Price, D. L.; DeLong, M. R. Alzheimers disease: A disorder of cortical cholinergic innervation. Science 219:1184-1189; 1983.
7. Deutsch, J. A. The cholinergic synapse and the site of memory. Science 174:788-794; 1971.
8. Flynn, C. J.; Wecker, L. Concomitant increases in the levels of choline and free fatty acids in rat brain: Evidence supporting the seizure induced hydrolysis of phosphatidylcholine. J. Neurochem. 48:1178-1184; 1987.
9. Gage, F. H.; Björklund, A.; Stenevi, U. Intrahippocampal septal grafts ameliorate learning impairments in aged rats. Science 225: 533-536; 1984.
10. Horsman, M. R.; Hoyer, M.; Honess, D. J.; Dennis, I. F.; Overgaard, J. Nicotinamide pharmacokinetics in humans and mice: A comparative assessment and the implications for radiotherapy. Radiother. Oncol. 27:131-139; 1993.
11. Irwin, S. Comprehensive observational assessment: Ia. A systematic quantitative procedure for assessing the behavioral and physiological state of the mouse. Psychopharmacology (Berlin) 13: 222-257; 1968.
12. Jenden, D. J.; Rice, K. M.; Roche, M.; Booth, R. A.; Lauretz, S. D. Effects of nicotinamide on choline and acetylcholine levels in rats. Adv. Neurol. 51:131-138; 1990.
13. Jope, R. S. High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis. Brain Res. Rev. 1:313-344; 1979.
14. Kang-Lee, Y. A. E.; McKee, R. W.; Wright, S. M.; Swenseid, M. E.; Jenden, D. J.; Jope, R. S. Metabolic effects of nicotinamide administration in rats. J. Nutr. 113:215-221; 1983.
15. Katzman, R.; Saitoh, T. Advances in Alzheimer's disease. FASEB J. 5:278-286; 1991.
16. Klein, J.; Köppen, A.; Löffelholz, K. Uptake and storage of choline by rat brain: Influence of dietary choline supplementation. J. Neurochem. 57:370-375; 1991.
17. Klein, J.; Köppen, A.; Löffelholz, K.; Schmitthenner, J. Uptake and metabolism of choline by rat brain after acute choline administration. J. Neurochem. 58:870-876; 1992.
18. 2 but not from phospholipase D. Brain Res. 630:337-340; 1993.
19. Köppen, A.; Klein, J.; Holler T.; Löffelholz, K. Synergistic effect of nicotinamide and choline administration on extracellular choline levels in the brain. J. Pharmacol. Exp. Ther. 266:720-725; 1993.
20. Koshimura, K.; Miwa, S.; Lee, K.; Hayashi, Y.; Hasegawa, H.; Hamahata, K.; Fujiwara, M.; Kimura, M.; Itokawa, Y. Effects of choline administration on in vivo release and biosynthesis of acetylcholine in the rat striatum as studied by in vivo brain microdialysis. J. Neurochem. 54:533-539; 1990.
21. Kumar, V.; Calache, M. Treatment of Alzheimer's disease with cholinergic drugs. Int. J. Clin. Pharmacol. Ther. Toxicol. 29:23-37; 1991.
22. Lanman, R. C.; Schanker, L. S. Transport of choline out of the cranial cerebrospinal fluid spaces of the rabbit. J. Pharmacol. Exp. Ther. 215:563-568; 1980.
23. McNamara, R. K.; Skelton, R. W. The neuropharmacological and neurochemical basis of place learning in the Morris water maze. Brain Res. Rev. 18:33-49; 1993.
24. Miettinen, R.; Sirviö, S.; Riekkinen, R.; Laakso, M. P.; Riekkinen, M.; Riekkinen, P., Jr. Neocortical, hippocampal and septal parvalbumin-and somatostatin-containing neurons in young and aged rats: Correlation with passive avoidance and water maze performance. Neuroscience 53:367-378; 1993.
25. Möhler, H.; Polc, P.; Cumin, R.; Pieri, L.; Kettler, R. Nicotinamide is a brain constituent with benzodiazepine-like actions. Nature 278:563-565; 1979.
26. Morris, R. G. M. Development of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11:181-188; 1984.
27. Mrochek, J. E.; Jolley, R. L.; Young, D. S.; Turner, W. J. Metabolic response of humans to ingestion of nicotinic acid and nicotinamide. Clin. Chem. 22:1821-1827; 1976.
28. Paxinos, G.; Watson, C. The rat brain in stereotaxis coordinates. San Diego: Academic Press; 1986.
29. Santiago, M.; Westerink, B. H. C. Characterization of the in vivo release of dopamine as recorded by different types of intracerebral microdialysis probes. Naunyn Schmiedebergs Arch. Pharmacol. 342:407-414; 1990.
30. Van der Staay, F.-J.; De Jonge, M. Effects of age on water escape behavior and on repeated acquisition in rats. Behav. Neural Biol. 60:33-41; 1993.
31. Wecker, L. Choline utilization by central cholinergic neurons. In: Wurtman, R. J.; Wurtman, J. J., eds. Nutrition and the brain. Vol. 8. New York: Raven Press; 1990:147-162.
32. Westerink, B. H. C.; deBoer, P. Effect of choline administration on the release of acetylcholine from the striatum as determined by microdialysis in awake rats. Neurosci. Lett. 112:297-301; 1990.
33. Winer, B. J. Statistical principles in experimental design. New York: McGraw-Hill; 1971.