Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus

Infection and Immunity

Volumn 64, Issue 2, 1996, Pages 466-471

  De Bernardis, Flavia ^a   Chiani, Paola ^a   Ciccozzi, Massimo ^a   Pellegrini, Guido ^a   Ceddia, Tommaso ^b   D'Offizzi, Giampiero ^c   Quinti, Isabella ^c   Sullivan, Patrick A ^d   Cassone, Antonio ^a,e  

^a Istituto Superiore di Sanità   (New Zealand)

^b UNIVERSITY OF L'AQUILA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE;

ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; ENZYME RELEASE; FUNGAL GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; PATHOGENICITY; PRIORITY JOURNAL; THRUSH;

EID: 0030031314     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.2.466-471.1996     Document Type: Article

References (45)

1. Agresti, M. G., F. De Bernardis, F. Mondello, et al. 1994. Clinical and mycological evaluation of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS patients. Eur. J Epidemiol. 10:17-22.
2. Barchiesi, F., A. L. Colombo, D. A. McGough, A. W. Fothergill, and M. G. Rinaldi. 1994. In vitro activity of itraconazole against fiuconazole-susceptible and - resistant Candida albicans isolates from oral cavities of patients infected with human immunodeficiency virus Antimicrob. Agents Chemother 38: 1530-1533.
3. Boerlin, P., F. Berlin-Petzold, C. Durussel, M. Addo, J. L. Pagani, J. P. Chave, and J. Bille. 1995. Cluster of oral atypical Candida albicans isolates in a group of human immunodeficiency virus-positive drug users. J. Clin. Microbiol 33:1129-1135.
4. Brawner, D. L., and J. E. Cutler. 1989. Oral Candida albicans isolates from nonhospitalized normal carriers, immunocompetent hospitalized patients, and immunocompromised patients with or without acquired immunodeficiency syndrome J Clin. Microbiol. 27:1335-1341.
5. Bruatto, M., V. Vidotto, G. Marinuzzi, R. Raiteri, and A. Sinicco. 1991. Candida albicans biotypes in human immunodeficiency virus type 1-infectcd patients with oral candidiasis before and after antifungal therapy. J. Clin Microbiol. 29:726-730.
6. + lymphocytes in resistance to mucosal candidiasis. Infect. Immun. 59:2447-2455.
7. Carruba, G., E. Pontierl, F. De Bernardis, P. Martino, and A. Cassone. 1991. DNA fingerprinting and electrophoretic karyotype of environmental and clinical isolates of Candida parapvilosis. J. Clin. Microbiol 29:916-922.
8. Cassone, A., M. Boccanera, D. Adriani, G. Santoni, and F. De Bernardis. 1995. Rats clearing a vaginal infection by Candida albicans acquire specific, antibody-mediated resistance to vaginal reinfection. Infect. Immun. 63:2619-2624.
9. Cutler, J.E. 1991. Putative virulence factors of Candida albicans. Annu Rev Microbiol 45:187-218.
10. De Bernardis, A., L. Agatensi, I. K. Ross, G. W. Emerson, R. Lorenzini, P. A. Sullivan, and A. Cassone. 1990 Evidence for a role for secreted aspartate proteinase of Candida albicans in vulvovaginal candidiasis. J. Infect Dis. 161:1276-1283.
11. De Bernardis, F., M. Boccanera, L. Rainaldi, C. E. Guerra, I. Quinti, and A. Cassone. 1992. The secretion of aspartyl proteinase, a virulence enzyme, by isolates of Candida albicans from the oral cavity of HIV-infected subjects Eur. J. Epidemiol. 8:362-367.
12. De Bernardis, F., A. Cassone, J. Sturtevant, and R. A. Calderone. 1995 Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis Infect. Immun. 63:1887-1892.
13. Fauci, A. S. 1988. The human immunodeficiency virus: infectivity and mechanisms of pathogenesis Science 239:617
14. Fox, R., R. Nealk, C. L. S. Leen, M. E. Ellis, and B. K. Mandal. 1991 Fluconazole-resistant Candida in AIDS. J. Infect. 22:201-204
15. Holmberg, K., and R. D. Meyer. 1986. Fungal infections in patients with AIDS and AIDS-related complex. Scand. J. Infect. Dis. 18:179-185.
16. Hube, B., M. Monod, D. A. Schofield, A. J. P. Drown, and N. A. R. Gow. 1994 Expression of seven members of the gene family encoding secretory aspartyl proteinase in Candida albicans Mol Microbiol. 14:87-89.
17. Iman, N., C. J. Carpenter, H. M. Kenneth, A. Fisher, M. Stein, and S. B. Danforth. 1990. Hierarchical pattern of mucosal candidal infection in HIV-seropositive women Am. J Med 89:142-146.
18. Kaminishi, H., H. Miyaguchi, T. Tamaki, N. Suenaga, M. Hisamatsu, I. Mihashi, H. Matstimoto, H. Maeda, and Y. Hagihara. 1995. Degiadation of humoral host defense by Candida albicans proteinase. Infect. Immun. 63: 984-988.
19. Klein, R. S., C. A. Harris, C. Butkus Small, B. Moll, M. Lesser, and G. H. Friendland. 1984. Oral candidiasis in high risk patients as the initial manifestation of the acquired immunodeficiency syndrome N. Engl. J. Med 311:354-357
20. Lupetti, A., G. Guzzi, A. Paladini, K. Swart, M. Campa, and S. Senesi. 1995. Molecular typing of Candida albicans in oral candidiasis: karyotype epidemiology with human immunodeficiency virus-positive patients in comparison with that with healthy carriers J. Clin. Microbiol. 33:1238-1248.
21. Magee, B. B., J. A. German, B. Hube, R. Wright, P. J. Sullivan, and P. T. Magee. 1993. The genes encoding the secreted aspartyl proteinase of Candida albicans constitute a family with at least three members. Infect. Immun. 61:3240-3243
22. Magee, B. B., Y. Koltin, J. A. Gorman, and P. T. Magee. 1988. Assignment of cloned genes to the seven electrophoretically separated Candida albicans chromosomes. Mol. Cell. Biol. 8:4721-4726.
23. Magee, P. T., L. Bowdin, and J. Staudinger. 1992. Comparison of molecular typing methods for Candida albicans. J. Clin. Microbiol 30:2674-2679.
24. McCullough, M., B. Ross, and P. Read. 1995. Characterization of genetically distinct subgroup of Candida albicans strains isolated from oral cavities of patients infected with human immunodeficiency virus J Clin Microbiol 33:696-700
25. McDonald, F., and F. C. Odds. 1983 Virulence for mice of a proteinase secreting strain of Candida albicans and a proteinase-deficient mutant. J. Gen. Microbiol 129:431-438.
26. Mencacci, A., A. Torosantucci, R. Spaccapelo, L. Romani, F. Bistoni, and A. Cassone. 1994. A mannoprotein constituent Candida albicans that elicits different levels of delayed-type hypersensitivity, cytokine production, and anticandidal protection in mice Infect. Immun. 62:5353-5360.
27. Merz, W. G., C. Connelly, and P. Hieter. 1988. Variation of electrophoretic karyotypes among clinical isolates of Candida albicans. J. Clin. Microbiol 26:842-845.
28. Meyer, S. A., G. Ahearn, and D. Yarrow. 1984. Genus Candida Berkhout, p 764-767. In N J W. Kreger (ed.). The yeasts, a taxonomic study. Elsevier Science Publishing Inc, Amsterdam.
29. Mondello, F., M. Guglielminetti, A. Torosantucci, T. Ceddia, L. Agatensi, and A. Cassone. 1986 Yeast species isolated from outpatients with vulvovaginal candidosis attending a gynecological center in Rome. IRCS Med. Sci. 14:746-747.
30. Monod, M., G. Togni, B. Hube, and D. Sanglard. 1994 Multiplicity of genes encoding secreted aspartic proteinases in Candida species Mol. Microbiol. 13:357-368.
31. Morrison, C. J., S. F. Hursl, S. L. Bragg, R. J. Kujkendall, H. Diaz, J. Pohl, and E. Reiss. 1993 Heterogeneity of the purified extracellular aspartyl proteindse from Candida albicans. characterization with monoclonal antibodies and N-terminal amino acid sequence analysis. Infect. Immun. 61:2030-2036
32. Odds, F. C. 1988. Candida and candidosis. Baillière Tindall, London.
33. Pfaller, M. A., J. Rhine-Chalberg, S. W. Redding, G. Smith, A. W. Farinacci, A. W. Fothergill, and M. G. Rinaldi. 1994. Variations in fluconazole susceptibility and electrophoretic karyotype among oral isolates of Candida albicans from patients with AIDS and oral candidiasis. J. Clin. Microbiol. 32:59-64
34. Quinti, I., C. Palma, E. C. Guerra, et al. 1991. Proliferative and cytotoxic responses to mannoproteins of Candida albicans by peripheral blood lymphocytes of HIV-infected subjects Clin. Exp. Immunol 85:485-492.
35. Romani, L., S. Mocci, C. Bietta, L. Lanfaloni, P. Puccetti, and F. Bistoni. 1991. Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance. Infect. Immun. 59:4647-4654.
36. Ross, I. K., F. De Bernardis, G. W. Emerson, A. Cassone, and P. A. Sullivan. 1990. The secreted aspartate proteinase of Candida albicans' physiology of secretion and virulence of a proteinase-deficient mutant. J. Gen. Microbiol. 136:687-694.
37. Ruchel, R., F. De Bernardis, T. L. Ray, P. A. Sullivan, and G. T. Cole. 1992. Candida acid proteinases. J. Med. Vet. Mycol. 29(Suppl.):1-9.
38. Schmid, J., F. C. Odds, M. J. Wiselka, K. G. Nicholson, and D. R. Soll. 1992. Genetic similarity and maintenance of Candida albicans strains from a group of AIDS patients, demonstrated by DNA fingerprinting. J. Clin Microbiol. 30:935-941.
39. Soll, D. R. 1992. High-frequency switching in Candida albicans. Clin Microbiol. Rev. 5:183-203.
40. Sullivan, D., D. Bennett, M. Henman, P. Harwood, S. Flint, F. Mukahy, D. Shanley, and D. Coleman. 1993 Oligonucleotide fingerprinting of isolates of Candida species other than C. albicans and of atypical Candida species from human immunodeficiency virus-positive and AIDS patients. J. Clin. Microbiol. 31:2124-2133.
41. Torosantucci, A., C. Bromuro, M. J. Gomez, C. M. Ausiello, F. Urbani, and A. Cassone. 1993. Identification of a 65 kDa mannoprotein constituent as a main target of human cell-mediated immune response to Candida albicans J. Infect. Dis. 168:427-435.
42. Tsuchiya, T., M. Taguchi, Y. Fukazawa, and T. Shinoda. Serological characterization Methods Microbiol. 16:75-26.
43. Vazquez, J. A., A. Beckley, J. D. Sobel, and M. J. Zervos. 1991. Comparison of restriction enzyme analysis and pulsed-field gradient gel electrophoresis as typing systems for Candida albicans. J. Clin. Microbiol. 29:962-967.
44. Vollrath, D., and R. W. Davis. 1987 Resolution of DNA molecules greater than 5 megabases by contour clamped homogenous electric fields. Nucleic Acids Res. 15:7865-7876.
45. Whelan, W. L., D. R. Kirsch, K. J. Kwon-Chung, S. M. Wahl, and P. D. Smith. 1990 Candida albicans in patients with the acquired immunodeficiency syndrome: absence of a novel or hypervirulent strain. J. Infect. Dis. 162:513-518.