Synthesis of 2-oxindole derivatives via the intramolecular Heck reaction on solid support

Tetrahedron Letters

Volumn 38, Issue 36, 1997, Pages 6473-6476

  Arumugam, Vijayalaksmi ^a   Routledge, Anne ^a   Abell, Chris ^a   Balasubramanian, Shankar ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXINDOLE DERIVATIVE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030879776     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01481-0     Document Type: Article

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19. 2O (1:1) (5 ml), 3 × DMF (5 ml), 3 × DCM (5 ml)) and dried under vacuum for 24 hours. The (E)- and (Z)- 3-ethylidene-2-oxindoles 8 were cleaved by treating with 25% TFA in DCM for 18 hours at ambient temperature.
20. 2O (5 ml), 3 × THF (5 ml), 3 × MeOH (5 ml), 3 × DCM (5 ml)) and dried under vacuum for 24 hours. The oxindole 9a was cleaved by treating with 25% TFA in DCM for 18 hours at ambient temperature. For the diethyl malonate derivative, conditions were the same except that DMF was used as a solvent and the reaction temperature was 80° C.