Syntheses and anticancer activity of ribonucleoside analogues containing thai-substituted five-membered heterocyclic base

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 13, 1997, Pages 1607-1610

  Ding, Yun ^a   Zhang, Yun Yan ^a   Zhang, Jiong ^a,b   Chen, Yao Quan ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b E11 SSH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; HETEROCYCLIC COMPOUND; RIBONUCLEOSIDE DERIVATIVE; THIADIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ANALYSIS;

EID: 0030879121     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00274-6     Document Type: Article

References (28)

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5. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
6. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
7. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
8. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
9. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
10. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
11. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
12. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
13. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
14. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
15. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
16. For examples, see Hirota, K.; Tomishi, T.; Maki, Y. Heterocycles 1987, 26, 3089; Belleau, B.; Dixit, D.; Nguyen-Ga, N.; Kraus, J.L. At 5th International Conference on AIDS. Montreal, Canada, June 4-9, 1989; Palomino, E.; Meltsner, B.R.: Kessel, D.; Horwitz, J.P.J. Med. Chem. 1990, 33, 258; Kung, P.P.; Jones, R.A. Tetrahedron Lett. 1991, 32, 3919; Secrist III, J.A.; Tiwari, K.N.; Riordan, J.M.; Montgomery, J.A. J. Med. Chem. 1991, 33, 2361; Wigerinck, P.; Snoeck R.; Claes, P.; De Clercq, E.; Herdewijn, P. ibid. 1991, 34, 1767; Dyson, M.R.; Coe, P.L.; Walker, R.T. J. C. S. Chem. Commun. 1991, 741; Goodwin, J.T.; Glick, G.O. Tetrahedron Lett. 1993, 34, 5549; Jeong, L.S.: Nicklaus, M.C.; George, C.; Marquez, V.E. ibid 1994, 35, 7569; 7573; Xiang, Y.; Teng, Q.; Chu, C.K. ibid 1995, 36, 3781; Van Praanen, N.A.; Freeman, G.A; Short, S.A.; Harvey, R.; Jansen, R.; Szczech, G.; Koszalka, G.W. J. Med Chem. 1996, 39, 538; Rahim, S.G.; Trivedi, N.; Bogunovic-Batchelor, M.V.; Hardy, G.W.; Mills, G.; Selway, J.W.T.; Snowden, W.; Littler, E.; Coe, P.L.; Basnak, I.; Walker, R.T. ibid 1996, 39, 789; Saluja, S.; Zou, R.; Drach, J.C.; Townsend, L.B. ibid 1996, 39, 881; Nishizono, N.; Koike, N.; Yamagata, Y.; Fujii, S.; Matsuda, A. Tetrahedron Lett. 1996, 37, 925.
17. Hohnjec, M.; Kobe, J.; Valcavi, U.; Japelj, M. J. Heterocycl. Chem., 1975, 12, 909.
18. + - base), 102 (base).
19. 4S: 247.0627. Found: 247.0586.
20. 4S: 301.0344. Found: 301.0355.
21. 5S: 250,0498. Found: 250.0502.
22. 2: 265.0191. Found: 265.0185.
23. 4S (base), 102.0000. Found. 102.0000.
24. Ueda, T. In Chemistry of Nucleosides and Nucleotides, Townsend, L.B. Ed.; Plenum Press: New York and London, 1988. Vol. 1. pp. 2-5; Srivastava, P.C.; Robins, R.K.; Meyer, Jr., R.B. ibid., pp. 130-136.
25. Ueda, T. In Chemistry of Nucleosides and Nucleotides, Townsend, L.B. Ed.; Plenum Press: New York and London, 1988. Vol. 1. pp. 2-5; Srivastava, P.C.; Robins, R.K.; Meyer, Jr., R.B. ibid., pp. 130-136.
26. 2: C, 31.70: H, 4.18; N, 15.85. Found: C, 31.57; H, 4.03; N, 15.75.
27. +).
28. 3.