-
2
-
-
0029873472
-
Construction of a high affinity zinc-switch in the k-opioid receptor
-
THIRSTRUP, K., C. E. ELLING, S. A. HJORTH & T. W. SCHWARTZ. 1996. Construction of a high affinity zinc-switch in the k-opioid receptor. J. Biol. Chem. 271: 7875-7878.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7875-7878
-
-
Thirstrup, K.1
Elling, C.E.2
Hjorth, S.A.3
Schwartz, T.W.4
-
3
-
-
0026660322
-
Modeling of G-protein-coupled receptors: Application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors
-
TRUMPP-KALLMEYER, S., J. HOFLACK, A. BRUINVELS & M. HIBERT. 1992. Modeling of G-protein-coupled receptors: Application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors. J. Med. Chem. 35: 3448-3462.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3448-3462
-
-
Trumpp-Kallmeyer, S.1
Hoflack, J.2
Bruinvels, A.3
Hibert, M.4
-
4
-
-
0027465713
-
Modeling of transmembrane seven helix bundles
-
CRONET, P., C. SANDER & G. VRIEND. 1993. Modeling of transmembrane seven helix bundles. Protein Eng. 6: 59-64.
-
(1993)
Protein Eng.
, vol.6
, pp. 59-64
-
-
Cronet, P.1
Sander, C.2
Vriend, G.3
-
5
-
-
0027506471
-
The probable arrangement of the helices in G protein-coupled receptors
-
BALDWIN, J. 1993. The probable arrangement of the helices in G protein-coupled receptors. EMBO J. 12: 1693-1703.
-
(1993)
EMBO J.
, vol.12
, pp. 1693-1703
-
-
Baldwin, J.1
-
6
-
-
0027933763
-
Locating ligand-binding sites in 7TM receptors by protein engineering
-
SCHWARTZ, T. W. 1994. Locating ligand-binding sites in 7TM receptors by protein engineering. Curr. Opinion Biotech. 5: 434-444.
-
(1994)
Curr. Opinion Biotech.
, vol.5
, pp. 434-444
-
-
Schwartz, T.W.1
-
8
-
-
0026669569
-
Sequence Alignment of the G-Protein Coupled Receptor Superfamily
-
PROBST, W. C., L. A. SNYDER, D. I. SCHUSTER, J. BROSIUS & S. C. SEALFON. 1992. Sequence Alignment of the G-Protein Coupled Receptor Superfamily. DNA Cell Biol. 11: 1-20.
-
(1992)
DNA Cell Biol.
, vol.11
, pp. 1-20
-
-
Probst, W.C.1
Snyder, L.A.2
Schuster, D.I.3
Brosius, J.4
Sealfon, S.C.5
-
9
-
-
0024519931
-
Structural basis of β-adrenergic receptor function
-
STRADER, C. D., I. S. SIGAL & R. A. F. DIXON. 1989. Structural basis of β-adrenergic receptor function. FASEB J. 3: 1825-1832.
-
(1989)
FASEB J.
, vol.3
, pp. 1825-1832
-
-
Strader, C.D.1
Sigal, I.S.2
Dixon, R.A.F.3
-
11
-
-
0027043104
-
Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor
-
FONG, T. M., R. C. HUANG & C. D. STADER. 1992. Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor. J. Biol. Chem. 267:25664-25667.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25664-25667
-
-
Fong, T.M.1
Huang, R.C.2
Stader, C.D.3
-
12
-
-
0027402089
-
Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist
-
GETHER, U., T. E. JOHANSEN, R. M. SNIDER, J. A. LOWE III, S. NAKANISHI & T. W. SCHWARTZ. 1993. Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist. Nature 362: 345-348.
-
(1993)
Nature
, vol.362
, pp. 345-348
-
-
Gether, U.1
Johansen, T.E.2
Snider, R.M.3
Lowe III, J.A.4
Nakanishi, S.5
Schwartz, T.W.6
-
13
-
-
0027402090
-
Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345
-
FONG, T. M., M. A. CASCIERI, H. YU, A. BANSAL, C. SWAIN & C. D. STRADER. 1993. Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. Nature 362: 350-353.
-
(1993)
Nature
, vol.362
, pp. 350-353
-
-
Fong, T.M.1
Cascieri, M.A.2
Yu, H.3
Bansal, A.4
Swain, C.5
Strader, C.D.6
-
14
-
-
0028318167
-
Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor
-
CASCIERI, M. A., A. M. MACCLEOD, D. UNDERWOOD, L. SHIAO, E. BER, S. SADOWSKI, H. YU, K. J. MERCHANT, C. J. SWAIN, C. D. STRADER & T. M. FONG. 1994. Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor. J. Biol. Chem. 269: 6587-6591.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6587-6591
-
-
Cascieri, M.A.1
Maccleod, A.M.2
Underwood, D.3
Shiao, L.4
Ber, E.5
Sadowski, S.6
Yu, H.7
Merchant, K.J.8
Swain, C.J.9
Strader, C.D.10
Fong, T.M.11
-
15
-
-
0028076832
-
Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345
-
GETHER, U., L. NILSSON, J. A. LOWE III & T. W. SCHWARTZ. 1994. Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345. J. Biol. Chem. 269: 23959-23964.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23959-23964
-
-
Gether, U.1
Nilsson, L.2
Lowe III, J.A.3
Schwartz, T.W.4
-
16
-
-
0028293626
-
Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor
-
HUANG, R. C., H. YU, C. D. STRADER & T. M. FONG. 1994. Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor. Biochemistry 33: 3007-3013.
-
(1994)
Biochemistry
, vol.33
, pp. 3007-3013
-
-
Huang, R.C.1
Yu, H.2
Strader, C.D.3
Fong, T.M.4
-
17
-
-
0028043957
-
Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding
-
ROSENKILDE, M. M., M. CAHIR, U. GETHER, S. A. HJORTH & T. W. SCHWARTZ. 1994. Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding. J. Biol. Chem. 269: 28160-28164.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 28160-28164
-
-
Rosenkilde, M.M.1
Cahir, M.2
Gether, U.3
Hjorth, S.A.4
Schwartz, T.W.5
-
18
-
-
0027988149
-
Identification of peptide binding residues in the extracellular domains of the AT1 receptor
-
HJORTH, S. A., H. T. SCHAMBYE, W. J. GREENLEE & T. W. SCHWARTZ. 1994. Identification of peptide binding residues in the extracellular domains of the AT1 receptor. J. Biol. Chem. 269: 30953-30959.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 30953-30959
-
-
Hjorth, S.A.1
Schambye, H.T.2
Greenlee, W.J.3
Schwartz, T.W.4
-
19
-
-
0028926576
-
Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms
-
NODA, K., Y. SAAD, A. KONOSHITA, T. P. BOYLE, R. M. GRAHAM, A. HUSAIN & S. S. KARNIK. 1995. Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms. J. Biol. Chem. 270: 2284-2289.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 2284-2289
-
-
Noda, K.1
Saad, Y.2
Konoshita, A.3
Boyle, T.P.4
Graham, R.M.5
Husain, A.6
Karnik, S.S.7
-
20
-
-
0029025788
-
1)
-
1). J. Biol. Chem. 270: 14024-14030.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14024-14030
-
-
Yamano, Y.1
Ohyama, K.2
Kikyo, M.3
Sano, T.4
Nakagomi, Y.5
Inoue, Y.6
Nakamura, N.7
Morishima, I.8
Guo, D.9
Hamakubo, T.10
Inagami, T.11
-
22
-
-
0027986888
-
The ligand binding site of the neurokinin 2 receptor - Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor
-
BHOGAL, N., D. DONNELLY & J. B. C. FINDLAY. 1994. The ligand binding site of the neurokinin 2 receptor - Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor. J. Biol. Chem. 269:27269-27274.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 27269-27274
-
-
Bhogal, N.1
Donnelly, D.2
Findlay, J.B.C.3
-
23
-
-
0029165752
-
Identification of residues involved in ligand binding to the neurokinin-2 receptor
-
HUANG, R. C., P. P. VICARIO, C. D. STRADER & T. M. FONG. 1995. Identification of residues involved in ligand binding to the neurokinin-2 receptor. Biochemistry 34: 10048-10055.
-
(1995)
Biochemistry
, vol.34
, pp. 10048-10055
-
-
Huang, R.C.1
Vicario, P.P.2
Strader, C.D.3
Fong, T.M.4
-
24
-
-
0027787499
-
Conserved His VI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P
-
ZOFFMANN, S., U. GETHER & T. W. SCHWARTZ. 1993. Conserved His VI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P. FEBS Lett. 336: 506-510.
-
(1993)
FEBS Lett.
, vol.336
, pp. 506-510
-
-
Zoffmann, S.1
Gether, U.2
Schwartz, T.W.3
-
25
-
-
0028145295
-
The role of histidine 265 in antagonist binding to the neurokinin-1 receptor
-
FONG, T. M., H. YU, M. A. CASCIERI, D. UNDERWOOD, C. J. SWAIN & C. D. STRADER. 1994. The role of histidine 265 in antagonist binding to the neurokinin-1 receptor. J. Biol. Chem. 269: 2728-2732.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2728-2732
-
-
Fong, T.M.1
Yu, H.2
Cascieri, M.A.3
Underwood, D.4
Swain, C.J.5
Strader, C.D.6
-
26
-
-
0028169253
-
Acidic residues in extracellular loops of the human Y1 neuropeptide Y receptor are essential for ligand binding
-
WALKER, P., M. MUNOZ, R. MARTINEZ & M. C. PEITSCH. 1994. Acidic residues in extracellular loops of the human Y1 neuropeptide Y receptor are essential for ligand binding. J. Biol. Chem. 269: 2863-2869.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2863-2869
-
-
Walker, P.1
Munoz, M.2
Martinez, R.3
Peitsch, M.C.4
-
27
-
-
0029155366
-
Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding
-
SAUTEL, M., R. MARTINEZ, M. MUNOZ, M. C. PEITSCH, A. G. BECK-SICKINGER & P. WALKER. 1995. Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding. Mol. Cell. Endocrinol. 112: 215-222.
-
(1995)
Mol. Cell. Endocrinol.
, vol.112
, pp. 215-222
-
-
Sautel, M.1
Martinez, R.2
Munoz, M.3
Peitsch, M.C.4
Beck-Sickinger, A.G.5
Walker, P.6
-
28
-
-
0029100680
-
Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor
-
ROSE, P. M., P. FERNANADES, J. S. LYNCH, S. T. FRAZIER, S. M. FISHER, K. KODUKULA, B. KIENZLE & R. SEETHALA. 1995. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J. Biol. Chem. 270: 22661-22664.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 22661-22664
-
-
Rose, P.M.1
Fernanades, P.2
Lynch, J.S.3
Frazier, S.T.4
Fisher, S.M.5
Kodukula, K.6
Kienzle, B.7
Seethala, R.8
-
29
-
-
0028800462
-
Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY
-
LUNDELL, I., A. G. BLOMQVIST, M. M. BERGLUND, D. A. SCHOBER, D. JOHNSON, M. A. STATNICK, D. R. GEHLERT & D. LARHAMMER. 1995. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem. 270: 29123-29128.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 29123-29128
-
-
Lundell, I.1
Blomqvist, A.G.2
Berglund, M.M.3
Schober, D.A.4
Johnson, D.5
Statnick, M.A.6
Gehlert, D.R.7
Larhammer, D.8
-
30
-
-
0028892357
-
Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY
-
BARD, J. A., M. W. WALKER, T. A. BRANCHEK & R. L. WEINSHANK. 1995. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J. Biol. Chem. 270: 26762-26765.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26762-26765
-
-
Bard, J.A.1
Walker, M.W.2
Branchek, T.A.3
Weinshank, R.L.4
-
31
-
-
0028805778
-
Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype
-
GERALD, C., M. W. WALKER, P. J.-J. VAYSSE, C. HE, T. A. BRANCHEK & R. L. WEINSHANK. 1995. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J. Biol. Chem. 270: 26758-26761.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26758-26761
-
-
Gerald, C.1
Walker, M.W.2
Vaysse, P.J.-J.3
He, C.4
Branchek, T.A.5
Weinshank, R.L.6
-
32
-
-
0028916599
-
A hot spot of binding energy in a hormone-receptor interface
-
CLACKSON, T. & J. A. WELLS. 1995. A hot spot of binding energy in a hormone-receptor interface. Science 383-386.
-
(1995)
Science
, pp. 383-386
-
-
Clackson, T.1
Wells, J.A.2
-
33
-
-
0028928407
-
Discovery of L-162,313: A nonpeptide that mimics the biological actions of angiotensin II
-
KIVLIGHN, S. D., W. R. HUCKLE, G. J. ZINGARO, R. A. RIVERO, V. J. LOTTI, R. S. L. CHANG, T. W. SCHORN, N. KEVIN, R. G. JOHNSON, JR., W. J. GREENLEE & P. K. S. SIEGL. 1995. Discovery of L-162,313: A nonpeptide that mimics the biological actions of angiotensin II. Am. J. Physiol. 268: R820-R823.
-
(1995)
Am. J. Physiol.
, vol.268
-
-
Kivlighn, S.D.1
Huckle, W.R.2
Zingaro, G.J.3
Rivero, R.A.4
Lotti, V.J.5
Chang, R.S.L.6
Schorn, T.W.7
Kevin, N.8
Johnson Jr., R.G.9
Greenlee, W.J.10
Siegl, P.K.S.11
-
35
-
-
77049220618
-
Affinity and intrinsic activity in the theory of competitive inhibition - Part 1: Problems and theory
-
ARIËNS, E. J. 1954. Affinity and intrinsic activity in the theory of competitive inhibition - Part 1: Problems and theory. Arch. Int. Pharmacodyn. XCIX: 32-49.
-
(1954)
Arch. Int. Pharmacodyn.
, vol.99
, pp. 32-49
-
-
Ariëns, E.J.1
-
36
-
-
0028235782
-
Differentiation between binding sites for angiotensin II and non-peptide antagonists on the ATI receptors
-
SCHAMBYE, H. T., S. A. HJORTH, D. J. BERGSMA, G. SATHE & T. W. SCHWARTZ. 1994. Differentiation between binding sites for angiotensin II and non-peptide antagonists on the ATI receptors. Proc. Natl. Acad. Sci. USA 91: 7046-7050.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7046-7050
-
-
Schambye, H.T.1
Hjorth, S.A.2
Bergsma, D.J.3
Sathe, G.4
Schwartz, T.W.5
-
37
-
-
0028131452
-
Mutations in transmembrane segment VII of the ATI receptor differentiate between closely related insurmountable and competitive angiotensin antagonists
-
SCHAMBYE, H. T., B. V. WIJK, S. A. HJORTH, W. WIENEN, M. ENTZEROTH, D. J. BERGSMA & T. W. SCHWARTZ. 1994. Mutations in transmembrane segment VII of the ATI receptor differentiate between closely related insurmountable and competitive angiotensin antagonists. Br. J. Pharmacol. 113: 331-333.
-
(1994)
Br. J. Pharmacol.
, vol.113
, pp. 331-333
-
-
Schambye, H.T.1
Wijk, B.V.2
Hjorth, S.A.3
Wienen, W.4
Entzeroth, M.5
Bergsma, D.J.6
Schwartz, T.W.7
-
38
-
-
0026508416
-
A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor
-
EMONDS-ALT, X., P. VILAIN, P. GOULAOUIC, V. PROIETTO, D. V. BROEK, C. ADVENIER, E. NALINE, G. NELIAT, G. LE FUR & J.-C. BRELIÉRE. 1992. A potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. Life Sci. 50: 101-106.
-
(1992)
Life Sci.
, vol.50
, pp. 101-106
-
-
Emonds-Alt, X.1
Vilain, P.2
Goulaouic, P.3
Proietto, V.4
Broek, D.V.5
Advenier, C.6
Naline, E.7
Neliat, G.8
Fur, G.L.E.9
Breliére, J.-C.10
-
39
-
-
0027294053
-
2) receptor antagonist
-
2) receptor antagonist. Regulatory Peptides 46: 31-36.
-
(1993)
Regulatory Peptides
, vol.46
, pp. 31-36
-
-
Emonds-Alt, X.1
Advenier, C.2
Croci, T.3
Manara, L.4
Neliat, G.5
Poncelet, M.6
Proietto, V.7
Santucci, V.8
Soubrié, P.9
Van Broeck, D.10
Vilain, P.11
Le Fur, G.12
Breliére, J.-C.13
-
40
-
-
0011753598
-
Selective nonpeptide opioid antagonists
-
PORTOGHESE, P. S. 1993. Selective nonpeptide opioid antagonists. Handb. Exp. Pharmacol. 104: 276-296.
-
(1993)
Handb. Exp. Pharmacol.
, vol.104
, pp. 276-296
-
-
Portoghese, P.S.1
-
41
-
-
0024426708
-
A single amino acid substitution in the β-adrenergic receptor promotes partial agonist activity from antagonists
-
STRADER, C. D., M. R. CANDELORE, W. S. HILL, R. A. F. DIXON & I. S. SIGAL. 1989. A single amino acid substitution in the β-adrenergic receptor promotes partial agonist activity from antagonists. J. Biol. Chem. 264: 16470-16477.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 16470-16477
-
-
Strader, C.D.1
Candelore, M.R.2
Hill, W.S.3
Dixon, R.A.F.4
Sigal, I.S.5
|