Genetic factors in human hypertension

Current Opinion in Nephrology and Hypertension

Volumn 6, Issue 3, 1997, Pages 215-218

  Miura, Dennis S ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

18 HYDROXYHYDROCORTISONE; 18 OXOHYDROCORTISONE; ALDOSTERONE; ANGIOTENSIN; ANGIOTENSIN RECEPTOR; ANGIOTENSINOGEN; CORTICOTROPIN; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN; HYDROGEN; METHIONINE; NITRIC OXIDE; RENIN; SODIUM; STEROID 11BETA MONOOXYGENASE; THREONINE; TRANSFORMING GROWTH FACTOR BETA;

ALLELE; ARTICLE; BLOOD PRESSURE; CHROMOSOME ABERRATION; FAMILY STUDY; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HUMAN; HYPERALDOSTERONISM; HYPERTENSION; LIDDLE SYNDROME; PHENOTYPE; PRIORITY JOURNAL;

EID: 0030877438     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199705000-00003     Document Type: Article

References (46)

1. Sharma P: Genes for ischaemic stroke: strategies for their detection. J Hypertens 1996, 14:277-285.
2. Ott J: Cutting a Gordian knot in the linkage analysis of complex human traits. Am J Hum Genet 1990, 46:219-221.
3. Lander ES, Schork NJ: Genetic dissection of complex traits. Science 1994, 265:2037-2048.
4. Lindpaintner K: Genetic linkage analysis in hypertension: principles and practice. J Hypertens 1992, 10:121-124.
5. Lifton RP: Genetic determinants of human hypertension. Proc Natl Acad Sci U S A 1995, 92:8545-8551.
6. McIlhany ML, Shaffer JW, Hines EA Jr: The inheritability of blood pressure: an investigation of 200 pairs of twins using the cold pressor test. Johns Hopkins Med J 1975, 136:57-64.
7. Feinleib M, Garrison R, Borhani N, Rosenman R, Christian J: Studies of hypertension in twins. In Epidemiology and Control of Hypertension. Edited by Paul O. New York: Stratton Intercontinental Med Book Corp; 1975:3-17.
8. Biron P, Mongeau JG, Bertrand D: Familial aggregation of blood pressure in adopted and natural children. In Epidemiology and Control of Hypertension. Edited by Paul O. New York: Stratton Intercontinental Med Book Corp; 1975:397-404.
9. Pickering G: High Blood Pressure, 2nd edn. New York: Grune & Stratton; 1968.
10. Platt R: The influence of heredity. In The Epidemiology of Hypertension. Edited by Stamler J, Stamler R, Pullman TN. New York: Grune & Stratton; 1967.
11. + antiporter as a candidate gene in human essential hypertension. Hypertension 1991, 1:8-14.
12. Jeunemaitre X, Rigat B, Charru A, Houot AM, Soubrier F, Corvol P: Sib pair linkage analysis of renin gene haplotypes in essential human hypertension. Human Genet 1992, 88:301-306.
13. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel J: Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nature Genet 1992, 1:72-75.
14. Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P, Soubrier F: Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994, 24:63-69.
15. Nabika T, Bonnardeaux A, James M, Julier C, Jeunemaitre X, Corvol P, Lathrop M, Soubrier F: Evaluation of the SA locus in human hypertension. Hypertension 1995, 25:6-13.
16. Jeunemaitre X, Soubrier F, Kotelevtsev Y, Lifton RP, Williams C, Charru A, Hunt S, Hopkins PN, Williams RR, Lalouel JM, Corvol P: Molecular basis of human hypertension: role of angiotensinogen. Cell 1992, 71:169-180.
17. Lifton RP, Dluhy RG: Hypertension: Pathophysiology, Diagnosis and Management. Edited by Laragh J, Brenner BM. New York: Raven; 1995:2163-2176.
18. Liddle GW, Bledso T, Coppage WS: A familial renal disorder simulating primary aldosteronism but with negligible aldosterone cretion. Trans Assoc Am Physicians 1963, 76:199-213.
19. Gordon RD, Tunny TJ, Klemm SA, Hamlet SM: Hypertension: Pathophysiology, Diagnosis and Management. Edited by Laragh J, Brenner BM. New York: Raven; 1995:2111-2123.
20. Katsuya T, Koike G, Yee TW, Sharpe N, Jackson R, Norton R, Horiuchi M, Pratt RE, Dzau VJ, MacMahon S: Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease. Lancet 1995, 345:1600-1603.
21. Hingorani AD, Sharma P, Jia H, Hopper R, Brown MJ: Blood pressure and the M235T polymorphism of the angiotensinogen gene. Hypertension 1996, 28:907-911. The angiotensinogen gene locus link to hypertension and heart disease is a fascinating story. A number of polymorphic variants of the angiotensinogen gene have been identified with variable effects on blood pressure. This paper suggests that the polymorphic gene may not be the whole story in blood pressure regulation.
22. Hegele RA, Brunt JH, Connelly PW: A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate. Circulation 1994, 90:2207-2212.
23. Nishiuma S, Kario K, Kayaba K, Nagio N, Shimada K, Matsuo T, Matsuo M: Effect of the angiotensinogen gene Met235-Thr variant on blood pressure and other cardiovascular risk factors in two Japanese populations. J Hypertens 1995, 13:717-722.
24. Iwai N, Shimoike H, Ohmichi N, Kinoshita M: Angiotensinogen gene and blood pressure in the Japanese population. Hypertension 1995, 25:688-693.
25. Sutherland DJA, Ruse JL, Laidlaw JC: Hypertension increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. Can Med Assoc J 1966, 95:1109-1119.
26. New MI, Peterson RE: A new form of congenital adrenal hyperplasia. J Clin Endocrinol Metab 1967, 27:300-305.
27. Ulick S, Chu MD, Land MJ: Biosynthesis of 18-oxocortisol by aldosterone-producing adrenal tissue. J Biol Chem 1983, 258:5498-5502.
28. Gomez-Sanchez CE, Montgomery M, Ganguly A, Holland OB, Gomex-Sanchez EP, Grim CE, Weinberger MH: Elevated urinary excretion of 18-oxocortisol in glucocorticoid-suppressible aldosteronism. J Clin Endocrinol Metab 1984, 59:1022-1024.
29. Ulick S, Chan CK, Gill JR, Gutkin M, Letcher L, Mantero F, New MI: Defective fasciculata zone function as the mechanism of glucocorticoid-remediable aldosteronism. J Clin Endocrinol Metab 1990, 71:1151-1157.
30. Lifton RP, Dluhy RG, Powers M, Rich GM, Cook S, Ulick S, Lalouel JM: A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature (Lond) 1992, 355:262-265.
31. Lifton RP, Dluhy RG, Powers M, Rich GM, Gutkin M, Fallo F, Gill J, Feld L, Ganguly A, Laidlaw JC et al.: Hereditary hypertension caused by chimaeric gene duplications and ectopic expressions of aldosterone synthase. Nature Genet 1992, 2:66-74.
32. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR, Ulick S, Milora RV, Findling JW et al.: Liddle's syndrome: heritable human hypertension caused by mutations in beta subunit of the epithelial sodium channel. Cell 1994, 79:407-414.
33. Pratt JH, Jones JJ, Miller JZ, Wagner MA, Fineberg NS: Racial differences in aldosterone excretion and aldosterone concentration in children. N Engl J Med 1989, 321:1152-1157.
34. Weinberger MH: Salt sensitivity of blood pressure in humans. Hypertension 1996, 27:481-490. This paper reviews the controversies surrounding the relationship of dietary salt intake and hypertension. A discussion of epidemiologic factors as well as heritable influences is well done.
35. Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau MT, Brosnan MJ, Devlin AM, Kelman AW, Lindpaintner K, Dominiczak AF: Quantitative trait loci in genetically hypertensive rats: possible sex specificity. Hypertension 1996, 28:898-906.
36. Rapp JP, Deng AY: Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension. Hypertension 1995, 25:1121-1128.
37. Gardemann A, Weiss T, Schwartz O, Eberbach A, Katz N, Hehrlein FW, Tillmanns H, Wass W, Haberbosch W: Gene polymorphism but not catalytic activity of angiotensin l-converting enzyme is associated with coronary artery disease and myocardial infarction in low-risk patients. Circulation 1995, 92:2796-2799.
38. Singer DRJ, Missouris CG, Jeffery S: Angiotensin-converting enzyme gene polymorphism: what to do about all the confusion? Circulation 1996, 94:236-239. This is an editorial describing the controversies and confusion surrounding the link between the deletion variant of the angiotensin converting enzyme gene. The link between gene polymorphism and various forms of cardiovascular disease is of great interest.
39. McLaughlin KJ, Harden PN, Ueda S, Boulton-Jones JM, Connell JMC, Jardine AG: The role of genetic polymorphisms of angiotensin-converting enzyme in the progression of renal diseases. Hypertension 1996, 28:912-915.
40. Cambien F, Ricard S, Troesch A, Mallet C, Generenaz L, Evans A, Arveiler D, Luc G, Ruidavets JB, Poirer O: Polymorphisms of the transforming growth factor-beta1 gene in relation to myocardial infarction and blood pressure: the Etude Cas-Temoin de l'Infarctus du Myocarde (ECTIM) Study. Hypertension 1996, 28:881-887. The molecular biology of the vascular endothelium is becoming the new research area of hypertension regulation. This paper presents transforming growth factor-beta 1 which appears to regulate cellular growth and differentiation. The presence of specific measured polymorphisms may predict increased risks of cardiovascular disease.
41. Ichiki T, Labotsky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BLM, Inagami T: Effects of blood pressure and reduced exploratory behavior in mice lacking angiotensin II type 2 receptor. Nature 1995, 377:748-750.
42. Schiffrin EL: Endothelin: potential role in hypertension and vascular hypertrophy. Hypertension 1995, 25:1135-1143.
43. Benjamin N, Vane J: Nitric oxide and hypertension. Circulation 1996, 94:1197-1198.
44. Taddei S, Virdis A, Mattei P, Ghiadoni L, Sudano I, Salvetti A: Defective L-argenine-nitric oxide pathway in offspring of essential hypertensive patients. Circulation 1996, 94:1298-1303.
45. Schuster H, Wienker TF, Bahring S, Bilginturan N, Toka HR, Neitzel H, Jeschke E, Tokan O, Gilbert D, Lowe A et al.: Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nature Genet 1996, 13:98-100. This paper presents a genetic study in which there is a 50 mm Hg difference in affected individuals via a non-salt/water or angiotensin/renin mechanism. An interesting presentation of a blood pressure mechanism that is still unknown.
46. Luft FC: Blood pressure and salt and water-relevant genes. Nephrol Dial Transplant 1996, 11:1705-1729.