Involvement of transcription factor encoded by the mouse mi locus (MITF) in apoptosis of cultured mast cells induced by removal of interleukin-3

American Journal of Pathology

Volumn 151, Issue 4, 1997, Pages 1043-1051

  Tsujimura, Tohru ^a,b   Hashimoto, Koji ^a   Morii, Eiichi ^a   Tunio, Ghulam Muhammad ^a   Tsujino, Kumiko ^a   Kondo, Taizo ^a   Kanakura, Yuzuru ^a   Kitamura, Yukihiko ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 3; TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ETIOLOGY; GENE LOCUS; MAST CELL; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; CELL COUNT; CELLS, CULTURED; DNA FRAGMENTATION; DNA PRIMERS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-3; MALE; MAST CELLS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; SPLEEN; TRANSCRIPTION FACTORS;

EID: 0030874846     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Hodgkinson CA, Moore KJ, Nakayama A, Steingrimsson E, Copeland NG, Jenkins NA, Arnheiter H: Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell 1993, 74:395-404
2. Hughes JJ, Lingrel JB, Krakowsky JM, Anderson KP: A helix-loop-helix transcription factor-like gene is located at the mi locus. J Biol Chem 1993, 268:20687-20690
3. Steingrimsson E, Moore KJ, Lamoreux ML, Ferre-D'Amare AR, Burley SK, Zimring DCS, Skow LC, Hodgkinson CA, Arnheiter H, Copeland NG, Jenkins NA: Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nature Genet 1994, 8:256-263
4. Hemesath TJ, Steingrimsson E, McGill G, Hansen MJ, Vaught J, Hodgkinson CA, Arnheiter H, Copeland NG, Jenkins NA, Fisher DE: Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev 1994, 8:2770-2780
5. Silvers WK: The Coat Colors of Mice: A Model for Mammalian Gene Action and Interaction. New York, Springer-Verlag, 1979
6. Green MC: Catalog of mutant genes and polymorphic loci. Genetic Variants and Strains of the Laboratory Mouse. Edited by Lyon MF, Searle AG. Stuttgart, Germany, Gustav Fischer Verlag, 1981, pp 158-161
7. Stevens J, Loutit JF: Mast cells in spotted mutant mice (W, Ph, mi). Proc R Soc Lond 1982, 215:405-409
8. Stechschulte DJR, Sharma KN, Dileepan KM, Simpson N, Aggarwal J, Clancy JR, Jilka RL: Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57BL/6J mice. J Cell Physiol 1987, 132:565-570
9. Ebi Y, Kasugai T, Seino Y, Onoue H, Kanemoto T, Kitamura Y: Mechanism of mast cell deficiency in mutant mice of mi/mi genotype: an analysis by co-culture of mast cells and fibroblasts. Blood 1990, 75:1247-1251
10. Tachibana M, Hara Y, Vyas D, Hodgkinson C, Fex J, Grundfast K, Arnheiter H: Cochlear disorder associated with melanocyte anomaly in mice with a transgenic insertional mutation. Mol Cell Neurosci 1992, 3:433-445
11. Kasugai T, Oguri K, Jippo-Kanemoto T, Morimoto M, Yamatodani A, Yoshida K, Ebi Y, Isozaki K, Tei H, Tsujimura T, Nomura S, Okayama M, Kitamura Y: Deficient differentiation of mast cells in the skin of mi/mi mice: usefulness of in situ hybridization for evaluation of mast cell phenotype. Am J Pathol 1993, 143:1337-1347
12. Morii E, Takebayashi K, Motohashi H, Yamamoto M, Nomura S, Kitamura Y: Loss of DNA binding ability of the transcription factor encoded by the mutant mi locus. Biochem Biophys Res Commun 1994, 205:1299-1304
13. Morii E, Tsujimura T, Jippo T, Hashimoto K, Takebayashi K, Tsujino K, Nomura S, Yamamoto M, Kitamura Y: Regulation of mouse mast cell protease 6 gene expression by transcription factor encoded by the mi locus. Blood 1996, 88:2488-2494
14. Ebi Y, Kanakura Y, Jippo-Kanemoto T, Tsujimura T, Furitsu T, Ikeda H, Adachi S, Kasugai T, Nomura S, Kanayama Y, Yamatodani A, Nishikawa SI, Kitamura Y: Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit. Blood 1992, 80:1454-1462
15. Isozaki K, Tsujimura T, Nomura S, Morii E, Koshimizu U, Nishimune Y, Kitamura Y: Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype. Am J Pathol 1994, 145:827-836
16. Tsujimuta T, Morii E, Nozaki M, Hashimoto K, Moriyama Y, Takebayashi K, Kondo T, Kanakura Y, Kitamura Y: Involvement of transcription factor encoded by the locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice. Blood 1996, 88:1225-1233
17. Reith AD, Bernstein A: Molecular biology of the W and Steel loci. Genes and Phenotypes, vol 3. Edited by Davis KE, Tilghman S. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1991, pp 105-133
18. Bentley NJ, Eisen T, Goding CR: Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator. Mol Cell Biol 1994, 14:7996-8006
19. Yasumoto KI, Yokoyama K, Shibata K, Tomita Y, Shibahara S: Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol Cell Biol 1994, 14:8058-8070
20. Vätrik I, Mäkelä TP, Koskinen PJ, Klefstrom J, Alitalo K: Myc protein: partners and antagonists. Crit Rev Oncog 1994, 5:59-68
21. Bello-Fernandez C, Packham G, Cleveland JL: The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc Natl Acad Sci USA 1993, 90:7804-7808
22. Eilers M, Schirm S, Bishop JM: The Myc protein activates transcription of the α-prothymosin gene. EMBO J 1991, 10:133-141
23. Reisman D, Elkind NB, Roy B, Beamon J, Rotter V: c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ 1993, 4:57-65
24. Bevenisty N, Leder A, Kuo A, Leder P: An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding site. Genes Dev 1992, 6:2513-2523
25. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC: Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992, 69:119-128
26. Malde P, Collins MKL: Disregulation of Myc expression in murine bone marrow cells results in an inability to proliferate in sub-optimal growth factor and an increased sensitivity to DNA damage. Int Immunol 1994, 6:1169-1176
27. Nakahata T, Spicer SS, Cantey JR, Ogawa M: Clonal assay of mouse mast cell colonies in methylcellulose culture. Blood 1982, 60:352-361
28. v mice: evidence that cultured mast cells can give rise to both "connective tissue-type" and "mucosal" mast cells. J Exp Med 1985, 162:1025-1043
29. Mann R, Mulligan RC, Baltimore D: Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell 1983, 33:153-159
30. Kitayama H, Kanakura Y, Furitsu T, Tsujimura T, Oritani K, Ikeda H, Sugahara H, Mitsui H, Kanayama Y, Kitamura Y, Matsuzawa Y: Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell line. Blood 1995, 85:790-798
31. Yamatodani A, Maeyama K, Watanabe H, Wada H, Kitamura Y: Tissue distribution of histamine in a mutant mouse deficient in mast cells: clear evidence for the presence of non-mast-cell histamine. Biochem Pharmacol 1982, 31:305-309
32. Enerbäck L: Berberine sulfate binding to mast cell polyanions: a cytofluorometric method for the quantitation of heparin. Histochemistry 1974, 42:301-313
33. Jippo T, Tsujino K, Kim HM, Kim DK, Lee YM, Nawa Y, Kitamura Y: Expression of mast-cell-specific proteases in tissues of mice studied by in situ hybridization. Am J Pathol 1997, 150:1373-1382
34. Auffray C, Rougenon F: Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem 1980, 107:303-314
35. Reynolds DS, Stevens RL, Gurley DS, Lane WS, Austen KF, Serafine WE: Isolation and molecular cloning of mast cell carboxypeptidase A: a novel member of the carboxypeptidase gene family. J Biol Chem 1989, 264:20094-20099
36. Tokunaga K, Taniguchi H, Yoda K, Shimizu M, Sakiyama S: Nucleotide sequence of a full-length cDNA for mouse cytoskeletal β-actin mRNA. Nucleic Acids Res 1986, 14:2829
37. Jenkins JR, Rudge K, Redmond S, Wade-Evans A: Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53. Nucleic Acids Res 1984, 12:5609-5626
38. Watanabe-Fukunaga R, Brannan CI, Itoh N, Yonehara S, Copeland NG, Jenkins NA, Nagata S: The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol 1992, 148:1274-1279
39. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S: Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994, 76:969-976
40. Kume TU, Takada S, Obinata M: Probability that the commitment of murine erythroleukemia cell differentiation is determined by the c-myc level. J Mol Biol 1988, 202:779-786
41. Negrini M, Silini E, Kozak C, Tsujimoto Y, Croce CM: Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 1987, 49:455-463
42. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993, 74:609-619
43. Takebayashi K, Chida K, Tsukamoto I, Morii E, Munakata H, Arnheiter H, Kuroki T, Kitamura Y, Nomura S: The recessive phenotype displayed by a dominant negative microphthalmia-associated transcription factor mutant is a result of impaired nuclear localization potential. Mol Cell Biol 1996, 16:1203-1211
44. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992, 119:493-501
45. Mekori Y, Oh CK, Metcalfe DD: IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. J Immunol 1993, 151:3775-3784
46. Iemura A, Tsai M, Ando A, Wershil BK, Galli SJ: The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis. Am J Pathol 1994, 144:321-328
47. Yee NS, Paek I, Besmer P: Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice. J Exp Med 1994, 179:1777-1787
48. Stewart BW: Mechanisms of apoptosis: integration of genetic, biochemical and cellular indicators. J Natl Cancer Inst 1994, 86:1286-1296
49. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH: Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993, 362:849-852
50. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T: p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993, 362:847-849
51. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S-I, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991, 66:233-243
52. Tsai M, Tam S-Y, Veis DJ, Korsmeyer SJ, Galli SJ: Bcl-2 and mast cell survival. Bcl-2 is overexpressed in a growth factor-independent mouse mast cell line but mast cells develop in Bcl-2 null mice. FASEB J 1994, 8:A742
53. Hughes DPM, Crispe IN: A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J Exp Med 1995, 182: 1395-1401
54. Galli SJ: New concepts about the mast cell. N Engl J Med 1993, 328:257-265
55. Savill J, Fadok V, Henson P, Haslett C: Phagocyte recognition of cells undergoing apoptosis. Immunol Today 1993, 14:131-136