Effects of inhibitors of RNA and protein synthesis on the subcellular distribution of the eukaryotic translation initiation factor, eif-5a, and the HIV-1 Rev Protein

NeuroSignals

Volumn 6, Issue 3, 1997, Pages 143-149

  Shi, Xiao Ping ^a   Yin, Kuo Chang ^a   Waxman, Lloyd ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Eukaryotic translation initiation factor 5A; HIV 1 Rev; Subcellular distribution

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; ALPHA AMANITIN; CALNEXIN; CYCLOHEXIMIDE; DACTINOMYCIN; INITIATION FACTOR; INITIATION FACTOR 5A; PROTEIN SYNTHESIS INHIBITOR; PUROMYCIN; REV PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL POPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOLUS; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; RIBOSOME; RNA SYNTHESIS;

ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; COS CELLS; CYTOPLASM; GENE PRODUCTS, REV; HIV-1; HUMANS; NUCLEIC ACID SYNTHESIS INHIBITORS; PEPTIDE INITIATION FACTORS; PROTEIN SYNTHESIS INHIBITORS; RNA; RNA-BINDING PROTEINS;

ANIMALIA; EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030874587     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000109120     Document Type: Article

References (13)

1. Park MH, Wolff EC, Folk JE: Hypu-sinc: Its post-translational formation in eukaryotic initiation factor 5A and its potential role in cellular regulation. Biofactors 1993:4:95-104.
2. Park MH, Wolff EC, Folk JE: Is hypusine essential for eukaryotic cell proliferation? Trends Biochem Sci 1993;18:475-479.
3. Kang HA, Hershey JWB: Effect of initiation factor clF-5A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae. J Biol Chem 1994;269:3934-3940.
4. Shi X-P, Yin K-C, Zimolo ZA, Stem AM, Waxman L: The subcellular distribution of eukaryotic translation initiation factor, clF-SA, in cultured cells. Exp Cell Res 1996;225: 348-356.
5. Ruhl M, Himmelspach M, Bahr GM, Hammerschmid F, Jaksche H, Wolff B, Aschauer H, Farrington GK, Probst H, Bevec D, Hauber J: Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type I Rev activation domain mediating trans-activation. J Cell Biol 1993; 123:1309-1320.
6. Meyer BE, Malim MH: The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev 1994;8:1538-1547.
7. Richard N, Iacampo S, Cochrane A: HIV-1 Rev is capable of shuttling between the nucleus and cytoplasm. Virology 1994;204:123-131.
8. Cullen BR: RNA-sequence-me-dialed gene regulation in HIV-1. Infect Agents Dis 1994;3:68-76.
9. Fagan JM, Goldberg AL: Inhibitors of protein and RNA synthesis cause a rapid block in prostaglandin production at the prostaglandin synthase step. Proc Natl Acad Sci USA 1986;83:2771-2775.
10. Pachler JS, Yen TJ, Cleveland DW: Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell 1987;51:283-292.
11. Shi XP, Yin KC, Ahem J, Davis U, Stem AM, Waxman L: Effects of N‘-guanyl-l,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture. Biochim Bio-physActa 1996;1310:119-126.
12. Jakus J, Wolff EC, Park MH, Folk JE: Features of the spcrmidine-bind-ing site of deoxyhypusine synthase as derived from inhibition studies. J Biol Chem 1993;268:13151-13159.
13. Park MH, Wolff EC, Lee YB, Folk JE: Antiproliferative effects of inhibitors of deoxyhypusine synthase. J Biol Chem 1994,269:27827-27832.