A comparison of phenyl- and naphthyl-substituted tris(macrocycle), cation-conducting channels to assess the effect of extended aromaticity

Tetrahedron Letters

Volumn 38, Issue 36, 1997, Pages 6339-6342

  Maguire, Glenn E M ^a   Meadows, Eric S ^a   Murray, Clare L ^a   Gokel, George W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROWN ETHER DERIVATIVE; MACROCYCLIC COMPOUND;

ARTICLE; CONDUCTANCE; DRUG SYNTHESIS; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TECHNIQUE;

EID: 0030873987     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01458-5     Document Type: Article

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40. 12: 1400.0224. Found 1400.0278.
41. The planar bilayer chamber was prepared with 0.5 M NaCl, 0.001 M sodium phosphate (pH=7.0) solution on each side of the membrane. The membrane was formed by the painting method using a solution (30 mg/mL) of L-α-lecithin in decane. The channels were added as 1.0 μM solutions in trifluoroethanol and stirred for 10 minutes. After a 5 minute equilibration period, a holding voltage was applied and the channel responses were recorded using a Warner PC-505 patch clamp amplifier, a DigiData A/D converter and the aquisition software Axoscope.
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43. + conductance of ∼9 pS.