Investigation of different recombinant isoforms of grass group-V allergens (timothy grass pollen) isolated by low-stringency cDNA hybridization: Antibody binding capacity and allergenic activity

European Journal of Biochemistry

Volumn 247, Issue 1, 1997, Pages 217-223

  Gehlhar, Kirsten ^a   Petersen, Arnd ^a   Schramm, Gabriele ^a   Becker, Wolf Meinhard ^a   Schlaak, Max ^a   Bufe, Albrecht ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Allergenic activity; Grass pollen allergen; IgE reactivity; Isoform; Ribonuclease activity

Indexed keywords

ALLERGEN; RIBONUCLEASE;

ANTIGEN BINDING; ARTICLE; GENETIC RECOMBINATION; GRASS POLLEN; IMMUNOREACTIVITY; IMMUNOTHERAPY; NONHUMAN; POLLEN ALLERGY; PRIORITY JOURNAL;

ESCHERICHIA COLI; PHLEUM PRATENSE;

EID: 0030872895     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.00217.x     Document Type: Article

References (40)

1. D'Amato, G., Spieksma, F. Th. M. & Bonini, S. (1941) Allergenic pollen and pollinosis in Europe, pp. 49-65, Blackwell Scientific Publishers. Oxford.
2. Noon, L. (1911) Prophylactic inoculation against hay fever, Lancet 1, 1572.
3. Creticos, P. S. (1992) Immunotherapy with allergens, JAMA 268, 2834-2839.
4. Aalherse, R. C., van der Gaag, R. & Van Leuwen, J. (1983) Serologic aspects of IgG4 antibodies. J. Immunol. 130, 722-726.
5. AAAI Board of Directors (1995) Measurement of specific and non-specific IgG4 levels as diagnostic and prognostic tests for clinical allergy, J. Allergy Clin. Immunol. 95, 653-654.
6. Durham, S. R., Sun, Y., Varney, V. A., Jacobson, M., Sudderick, R. M., Machay, I. S., Kay, A. B. & Hamid, Q. A. (1992) Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J. Immunol. 148, 2390-2394.
7. Varney, V. A., Hamid, Q. A., Gaga, M., Sun, Y., Jacobson, M., Frew, A. J., Kay, A. B. & Durham, S. R. (1993) Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous response. J. Clin Invest. 92, 644-651.
8. Dreborg, S., Einarsson, R. & Longbottom, J. L. (1986) The chemistry and standardization of allergens, in Handbook of Experimental Immunology (Weir, D. M. & Herzenberg, L. A., eds) pp. 1:10.2, Blackwell Scientific, Oxford.
9. King, T. P., Hoffman, D., Lowenstein, H., Marsh, D. G., Platts-Mills. T. A. E. & Thomas, W. (1994) Allergen Nomenclature, Int. Arch. Allergy Immunol. 105, 224-233.
10. Sutton, B. J. & Gould, H. J. (1993) The IgE network, Nature 366, 421-428.
11. Bufe, A., Becker, W.-M., Schramm, G., Petersen, A., Mamat, U. & Schlaak, M. (1994) Major allergen PhI p Va (timothy grass) hears at least two different IgE-reactive epitopes. J. Allergy Clin. Immunol. 94, 173-181.
12. Scheiner, O. & Kraft, D. (1995) Basic and partial aspects of recombinant allergens. Allergy 50, 384-391.
13. Johnson, P. & Marsh, D. G. (1965) Isoallergens from rye grass pollen. Nature 206, 935-937.
14. Breiteneder, H., Ferreira, F., Hoffman-Sommergruber, K., Ebner, C., Breitenbach, M., Rumpold, H., Kraft, D. & Scheiner, O. (1993) Four recombinant isoforms of Cor a I. the major allergen of hazel pollen, show different IgE-hinding properties. Eur. J. Biochem. 212, 355-362.
15. Larsen, J. N., Stroman, P. & Ipsen, H. (1992) PCR based cloning and sequencing of isogenes encoding the tree pollen major allergen Car b 1 from Carpinus betulus. hornbeam. Mol. Immunol. 29, 703-711.
16. Ferreira, F., Hirtenlehner, K., Jilek, A., Godnik-Cvar, J., Breiteneder, H., Grimm, R., Hoffmann-Sommergruber, K., Scheiner, O., Kraft, D., Breitenbach, M., Rheinberger, H.-J. & Ebner, C. (1996) Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: Potential use of hypoallergenic isoforms for immunotherapy. J. Exp. Med. 183, 599-609.
17. Bute, A. Schramm, G., Keown, M. B., Schlaak, M. & Becker, W.-M. (1995) Major allergen Ph1 p Vb in timothy grass is a novel pollen RNase. FEBS Lett. 363, 6-12.
18. Sanger, F. Nicklen, S. & Coulson, A. R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci. USA 74, 5463-5469.
19. Laemmli, U. K. (1970) Cleavage of structural proetins during the assembly of the head of bacteriophage T4, Nature 227, 680-685.
20. Silvanovich, A., Astwood, J., Zhang, L., Olsen, E., Kisil, F., Sehon, A., Mohapatra, S. & Hill, R. (1991) Nucleotide sequence analysis of three cDNAs coding for Poa p IX isoallergens of Kentucky bluegrass pollen, J. Biol. Chem. 266, 1204-1210.
21. Saunal, H. & Van Regenmortel, H. V. M. (1995) Mapping of viral conformational epitopes using biosensor measurements, J. Immunol. Meth. 183, 33-44.
22. Barna, B., Ibenthal, W. D. & Heitefuss, R. (1989) Extracellular RNase activity in healthy and rust infected wheat leaves, Physiol. Mol. Plant Path. 35, 151-160.
23. Dreborg, S. (1985) Skin-prick test. Allergy 40, 55-59.
24. Petersen, A., Becker, W.-M. & Schlaak, M. (1994) Kpitope analysis of isofoms of the major allergen PhI p V by fingerprinting and microsequencing. Clin. Exp. Allergy 24, 250-256.
25. Mattiesen, F. & Lowenstein, H. (1991) Group-V allergens in grass pollens. I. Purification and characterization of group-V allergens from Pleum pratense pollen. Ph1 p V, Clin. Exp. Allergy 21, 297-307.
26. Petersen, A., Schramm, G., Becker, W.-M. & Schlaak, M. (1993) Comparison of four grass pollen species concerning their allergens of grass group-V by 2D immunoblotting and microsequencing, Biol. Chem. Hoppe-Seyler 374, 855-861.
27. Schramm, G., Petersen, A., Bute, A., Sehlaak, M. & Becker, W.-M. (1996) Identification and characterization of the major allergens of velvet grass (Holcus lanatus). Hol 1 1 and Hol 1 5. Int. Arch. Allergy Immunol. 110, 354-363.
28. Vrtala, S., Sperr, W. R., Reimitzer, I., van Ree, R., Laffler, S., Müller, W.-D., Lechner, K., Valent, P., Kraft, D., Scheiner, O. & Valenta. R. (1993) cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Ph1 p V allergen. J. Immunol. 151, 4773-4781.
29. Pham, N. H. & Baldo, B. A. (1995) Allergenic relationship between taxonomically diverse pollens, Clin. Exp. Allergy 25, 599-606.
30. Ipsen, H., Schou, C. & Klysner, S. (1993) Molecular biology and immunology of allergens (Kraft, D. & Schon. A., eds) pp. 219-222, CRC Press, Boca Raton.
31. Bufe, A., Betzel, C., Schramm, G., Petersen, A., Becker, W.-M., Schlaak, M., Perbandt, M., Dauter, Z. & Weber, W. (1996) Crystallization and preliminary diffraction data of a major pollen allergen: Crystal growth separates a low molecular mass form with elevated biological activity, J. Biol. Chem. 271, 27 193-27 196.
32. Ikagawa, S., Matsushita, S., Chen, Y.-Z., Ishikawa, T. & Nishimura, Y. (1996) Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T-cell response and T-cell receptor antagonism. J. Allergy Clin. Immunol. 97, 53-64.
33. Bond, J. F., Garman, R. D., Keating, K. M., Briner, T. J., Rafner, T., Klapper, D. G. & Rogers, B. L. (1991) Multiple Amb a I allergens demonstrate specific reactivity with IgE and T cells from ragweed-allergic patients. J. Immunol. 146, 3380-3385.
34. Ong, E. K., Knox, R. B. & Singh, M. B. (1995) Mapping of the antigenic and allergenic epitopes of Lol p Vb using gene fragmentation. Mol. Immunol. 32, 295-302.
35. Schramm, G., Bufe, A., Petersen, A., Haas, H., Schlaak, M. & Becker, W.-M. (1997) Antigenic and allergenic B cell epitope mapping on the recombinant major group I allergen of velvet grass pollen. rHol 1 1, J. Allergy Clin. Immunol., in the press.
36. Korenaga, M. Watanabe, N., Abe, T. & Hashiguchi, Y. (1996) Acceleration of IgE responses by treatment with recombinant interleukin-3 prior to infection with Trichinella spiralis in mice. Immunology 87, 642-646.
37. Yamaguchi, M., Hirai, K., Ohta, K., Suzuki, K., Kitani, S., Takaishi, T., Ito, K., Ra, C. & Morita, Y. (1996) Nonreleasing basophils convert to releasing basophils by culturing with II-3, J. Allergy Clin. Immunol. 97, 1279-1287.
38. Pauli, G., Oster, J. P., Deviller, P., Heiss, S., Bessot, J. C., Susani, M., Ferreira, F., Kraft, D. & Valenta, R. (1996) Skin testing with recombinant birch allergens rBet v1 and rBet v2: diagnostic value for birch pollen and associated allergies, J. Allergy Clin. Immunol. 97, 1100-1109.
39. Osterballe, O. (1982) Nasal and skin sensitivity during immunotherapy with two major allergens 19, 25 and partially purified extract of timothy grass pollen, Allergy 37, 169-177.
40. Nüchel Petersen, B., Janniche, H., Munch, E. P., Wihl, J. A., Böwadt, H., Ipsen, H. & Lowenstein, H. (1988) Immunotherapy with partially purified and standardized tree pollen extracts. Allergy 43, 353-362.