Time-course of deactivation of rat stomach ECL cells following cholecystokinin(B)/gastrin receptor blockade

British Journal of Pharmacology

Volumn 122, Issue 1, 1997, Pages 1-6

  Ding, X Q ^a   Lindstrom E ^a   Hakanson R ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

CCK(B) gastrin receptor antagonist; CCK(B) gastrin receptors; ECL cells; Gastrin; Histamine; Histidine decarboxylase (HDC); Pancreastatin

Indexed keywords

1 [2,3 DIHYDRO 1 (2' METHYLPHENACYL) 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL] 3 (3 METHYLPHENYL)UREA; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; CHROMOGRANIN A; GASTRIN; GASTRIN RECEPTOR; HISTAMINE; HISTIDINE DECARBOXYLASE; MESSENGER RNA; PANCREASTATIN; PEPTIDE; RP 73870; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOCRINE CELL; ENTEROCHROMAFFIN CELL; ENZYME ACTIVITY; GASTRIN BLOOD LEVEL; HISTAMINE RELEASE; HYPERGASTRINEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; STOMACH; STOMACH ACID SECRETION; TIME;

ANIMALS; ANTI-ULCER AGENTS; BENZODIAZEPINES; BODY WEIGHT; ENTEROCHROMAFFIN CELLS; GASTRIC MUCOSA; GASTRINS; HISTAMINE; HORMONE ANTAGONISTS; MALE; PANCREATIC HORMONES; PHENYLUREA COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ; RNA, MESSENGER; STOMACH; TIME FACTORS;

EID: 0030870141     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701316     Document Type: Article

References (42)

1. ANDERSSON, K., CABERO, J.L., MATTSSON, H. & HÅKANSON, R. (1996a). Gastric acid secretion after depletion of enterochromaffin-like cells histamine. Scand. J. Gastroenterol., 31, 24-30.
2. ANDERSSON, K., LINDSTRÖM, E., CHEN, D., MONSTEIN, H.-J., BOKETOFT, A. & HÅKANSON, R. (1996b). Depletion of enterochromaffin-like cells histamine increases histidine decarboxylase and chromogranin A mRNA levels in rat stomach by a gastrin-independent mechanism. Scand. J. Gastroenterol., 31, 959-965.
3. ASAHARA, M., KINOSHITA, Y., NAKATA, H., MATSUSHIMA, Y., NARIBAYASHI, Y., NAKAMURA, A., MATSUI, H., CHIHARA, K., YAMAMOTO, J., ICHIKAWA, A. & CHIBA, T. (1994). Gastrin receptor genes are expressed in gastric parietal and enterochromaffine-like cells of Mastomys natalensis. Dig. Dis. Sci., 39, 2149-2156.
4. BLACK, J.W. & SHANKLEY, N.P. (1987). How does gastrin act to stimulate oxyntic cell secretion? Trends Pharmacol. Sci., 8, 486-490.
5. CHEN, D., MONSTEIN, H.-J., NYLANDER, A.-G., ZHAO, C.-M., SUNDLER, F. & HAKANSON, R. (1994). Acute responses of rat stomach enterochromaffin-like cells to gastrin: Secretory activation and adaptation. Gastroenterology, 107, 18-27.
6. CHIBA, T., KINOSHITA, Y., MORISHITA, T., NAKATA, H., NAKAMURA, A. & HOSODA, S. (1991). Receptors for gastrin on gastric carcinoid tumor membranes of Mastomys natalensis. Biochem. Biophys. Res. Commun., 177, 739-744.
7. DIMALINE, R. & SANDVIK, A.K. (1991). Histidine decarboxylase gene expression in rat fundus is regulated by gastrin. FEBS Lett., 28, 20-22.
8. DIMALINE, R., EVANS, D., FORSTER, E.R., SANDVIK, A.K. & DOCKRAY, G.J. (1993). Control of gastric corpus chromogranin A messenger RNA abundance in the rat. Am. J. Physiol., 264, G583-588.
9. DING, X.-Q., CHEN, D. & HÅKANSON, R. (1995). Cholecystokinin-B receptor ligands of the dipeptoid series act as agonists on rat stomach histidine decarboxylase. Gastroenterology, 109, 1181-1187.
10. DING, X.-Q. & HÅKANSON, R. (1996a). Evaluation of potency and specificity of a series of cholecystokinin-B/gastrin receptor antagonists. Pharmacol. Toxicol., 79, 124-130.
11. DING, X.-Q. & HÅKANSON, R. (1996b). Effect of cholecystokinin-B gastrin receptor blockade on gastric acid secretion in conscious rats. Pharmacol. Toxicol., 79, 324-330.
12. DING, X.-Q., LINDSTRÖM, E. & HÅKANSON, R. (1997). Cholecystokinin-B/gastrin receptor blockade suppresses the activity of rat stomach ECL cells. Pharmacol. Toxicol., 81, 19-25.
13. EISSELE, R., PATBERG, H., KOOP, H., KRACK, W., LORENZ, W., MCKNIGHT, A.T. & ARNOLD, R. (1992). Effect of gastrin receptor blockade on endocrine cells in rats during achlorhydria. Gastroenterology, 103, 1596-1601.
14. GARLICHI, J., KONTUREK, P.K., MAJKA, J., KWIECIEN, N. & KONTUREK, S.J. (1990). Cholecystokinin receptor and vagal nerves in the control of food intake in rat. Am. J. Physiol., 258, E40-45.
15. HÅKANSON, R., CHEN, D. & SUNDLER, F. (1994). The ECL cells. In Physiology of the Gastrointestinal Tract. ed. Johnson, L.R. pp. 1171-1184. New York: Raven Press.
16. HÅKANSON, R., DING, X.-Q., NORLÉN, P. & CHEN, D. (1995). Circulating pancreastatin is a marker for the enterochromaffin-like cells of the rat stomach. Gastroenterology, 108, 1445-1452.
17. HÅKANSON, R., TIELEMANS, Y., CHEN, D., ANDERSSON, K., MATTSSON, H. & SUNDLER, F. (1992). The biology and pathobiology of the ECL cells. Yale J. Biol. Med., 65, 761-764.
18. HÅKANSON, R., TIELEMANS, Y., CHEN, D., ANDERSSON, K., MATTSSON, H. & SUNDLER, F. (1993). Time-dependent changes in enterochromaffin like cell kinetics in stomach of hypergastrinemic rats. Gastroenterology, 105, 15-21.
19. HÖCKER, M., ZHANG, Z.-S., FENSTERMACHER, D.A., TÅGERUD, S., CHULAK, M., JOSEPH, D. & WANG, T.C. (1996). Rat histidine decarboxylase promoter is regulated by gastrin through a protein kinase C pathway. Am. J. Physiol., 270, G619-633.
20. KAWABATA, S., KANAYAMA, S., SHINOMURA, Y., MIYAZAKI, Y., IMAMURA, I., MORIWAKI, K., WADA, H. & TARUI, S. (1991). Effect of CCK receptor antagonists, MK-329 and L-365,260 on CCK-induced acid secretion and HDC activity in the rat. Regul. Pept., 35, 1-10.
21. KIMURA, K., CHEN, D., LINDSTRÖM, E., ZHAO, C.-M. & HÅKANSON, R. (1997). Evidence that rat stomach ECL cells represent the main source of circulating pancreastatin. Regul. Pept., 68, 177-180.
22. LARSSON, H., CARLSSON, E., MATTSSON, H., LUNDELL, L., SUNDLER, F., SUNDELL, G., WALLMARK, B., WATANABE, T. & HÅKANSON, R. (1986). Plasma gastrin and gastric enterochromaffin like cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology, 90, 391-399.
23. LINDSTRÖM, E., BJÖRKQVIST, M., BOKETOFT, A., CHEN, D., ZHAO, C.-M., KIMURA, K. & HAKANSON, R. (1997). Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells. Regul. Pept., (in press).
24. MONSTEIN, H.-J., NYLANDER, A.-G. & CHEN, D. (1995). RNA extraction from gastrointestinal tract and pancreas by a modified Chomczynski and Sacchi method. Bio. Technol., 19, 340-343.
25. NISHIDA, A., MIYATA, K., TSUTSUMI, R., YUKI, H., AKUZAWA, S., KOBAYASHI, A., KAMATO, T., ITO, H., YAMANO, M., KATUYAMA, Y., SATOH, M., OHTA, M. & HONDA, K. (1994). Pharmacological profile of (R)-1-[2,3 dihydro-1-(2′-methylphenacyl)-2-oxo-5- phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl) urea (YM022), a new potent and selective gastrin/CCK-B receptor antagonist, in vitro and in vivo. J. Pharmacol. Exp. Ther., 269, 725-731.
26. NISHIDA, A., KOBAYASHI, A., AKUZAWA, S., TAKINAMI, Y., SHISHIDO, T., KAMATO, T., ITO, H., YAMANO, M., YUKI, H., NAGAKURA, Y., HONDA, K. & MIYATA, K. (1995). Gastrin receptor antagonist YM022 prevents hypersecretion after long term acid suppression. Am. J. Physiol., 269, G699-705.
27. 14 in rat stomach ECL cells. Regul. Pept., (in press).
28. PENDLEY, C.E., FITZPATRICK, L.R., CAPOLINO, A.-J., DAVIS, M.A., ESTERLINE, N.-J., JAKUBOWSKA, A., BERTRAND, P., GUYON, C., DUBROEUCQ, M.-C. & MARTIN, G.E. (1995). RP73870, a gastrin/CCK-B receptor antagonist with potent anti-ulcer activity in the rat. J. Pharmacol. Exp. Ther., 273, 1015-1022.
29. PRINZ, C., KAJIMURA, M., SCOTT, D.-R., MERCIER, F., HELANDER, H.-F. & SACHS, G. (1993). Histamine release from rat enterochromaffin like cells. Gastroenterology, 105, 449-461.
30. PRINZ, C., SCOTT, D.-R., HURWITZ, D., HELANDER, H.-F. & SACHS, G. (1994). Gastrin effects on isolated rat enterochromaffin like cells in primary culture. Am. J. Physiol., 267, G663-672.
31. ROCHE, S., GUSDINAR, T., BALI, J.-P. & MAGOUS, R. (1991a). 'Gastrin' and 'CCK' receptors on histamine- and somatostatin-containing cells from rabbit fundic mucosa. I. Characterization by means of agonists. Biochem. Pharmacol., 42, 765-770.
32. ROCHE, S., GUSDINAR, T., BALI, J.-P. & MAGOUS, R. (1991b). 'Gastrin' and 'CCK' receptors on histamine- and somatostatin-containing cells from rabbit fundic mucosa. II. Characterization by means of selective antagonists L-364,718 and L-365,260. Biochem. Pharmacol., 42, 771-776.
33. RÖNNBERG, A.-L. & HAKANSON, R. (1984). A simplified procedure for fluorometric determination of histamine in rat stomach. Agents Actions, 14, 195-199.
34. SANDVIK, A.K., DIMALINE, R., MARVIK, R., BRENNA, E. & WALDUM, H.-L. (1994). Gastrin regulates histidine decarboxylase activity and mRNA abundance in rat oxyntic mucosa. Am. J. Physiol., 267, G254-G258.
35. SANDVIK, A.K. & WALDUM, H.L. (1991). CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion. Am. J. Physiol., 260, G925-928.
36. SCHMASSMANN, A., GARNER, A., FLOGERZI, B., HASAN, M.Y., SANNER, M., VARGA, L. & HALTER, F. (1994). Cholecystokinin type B receptor antagonist PD 136,450 is a partial agonist in the stomach and a full agonist in the pancreas of the rat. Gut, 35, 270-274.
37. SONG, M., WONG, H., OHNING, G. & WALSH, J.H. (1996). Immunohistochemical localization of the gastrin CCK-B receptor in the rat stomach (abs). Gastroentrology, 110, A1120.
38. STADIL, F. & REHFELD, J.-F. (1973). Determination of serum gastrin. An evaluation of the reliability of a radioimmunoassay. Scand. J. Gastroenterol., 8, 101-112.
39. WALDUM, H.L., SANDVIK, A.-K., BRENNA, E. & PETERSEN, H. (1991). The gastrin-histamine sequence in the regulation of gastric acid secretion. Gut, 32, 698-700.
40. WILLIS, G.L., HANSKY, J. & SMITH, G.C. (1986). Central and peripheral proglumide administration and cholecystokinin-induced satiety. Regul. Pept., 15, 87-98.
41. WINKLER, H., APPS, D.-K. & FISCHER-COLBRIE, R. (1986). The molecular function of adrenal chromaffin granules: established facts and unresolved topics. Neuroscience, 18, 261-290.
42. WINKLER, H. & FISHER-COLBRIE, R. (1992). The chromogranins A and B: the first 25 years and future perspectives. Neuroscience, 49, 497-528.