Cholecystokinin-B/gastrin receptor blockade suppresses the activity of rat stomach ECL cells

Pharmacology and Toxicology

Volumn 81, Issue 1, 1997, Pages 19-25

  Ding, Xi Qin ^a   Lindström, Erik ^a   Håkanson, Rolf ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2,3 DIHYDRO 1 (2' METHYLPHENACYL) 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL] 3 (3 METHYLPHENYL)UREA; CHOLECYSTOKININ B RECEPTOR; CHROMOGRANIN A; GASTRIN 17; GASTRIN RECEPTOR; HISTAMINE; HISTIDINE DECARBOXYLASE; OMEPRAZOLE; RP 73870; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENTEROCHROMAFFIN CELL; HYPERGASTRINEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0030745181     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb00025.x     Document Type: Article

References (40)

1. Andersson, K., J. L. Cabero, H. Mattsson & R. Håkanson: Gastric acid secretion after depletion of enterochromaffin-like cell histamine. Scand. J. Gastroenterol. 1996a, 31, 24-30.
2. Andersson, K., E. Lindström, D. Chen, H.-J. Monstein, Å. Boketoft & R. Håkanson: Depletion of ECL-cell histamine increases histidine decarboxylase and chromogranin A mRNA levels in rat stomach by a gastrin-indenpendent mechanism. Scand. J. Gastroenterol. 1996b, 31, 959-965.
3. Asahara, M., Y. Kinoshita, H. Nakata, Y. Matsushima, Y Naribayashi, A. Nakamura, H. Matsui, K. Chihara, J. Yamamoto, A. Ichikawa & T. Chiba: Gastrin receptor genes are expressed in gastric parietal and enterochromaffin-like cells of Mastomys natalensis. Dig. Dis. Sci. 1994, 39, 2149-2156.
4. Beinfeld, M. C.: Cholecystokinin in the central nervous system: A minireview. Neuropeptides 1983, 3, 411-427.
5. Bertrand, P., G. A. Böhme, C. Durieux, C. Guyon, M. Capet, B. Jeantaud, P. Boudeau, B. Ducos, C. E. Pendley & G. E. Martin: Pharmacological properties of ureido-acctamides, new potent and selective non-peptide CCK gastrin receptor antagonists. Eur. J. Pharmacol. 1994, 262, 233-245.
6. 3H] L-365,260: A new potent and selective brain cholecystokinin (CCK-B) and gastrin receptor antagonist radioligand. Mol. Pharmacol. 1989, 35, 803-810.
7. Chen, D., H.-J. Monstein, A.-G. Nylander, C.-M. Zhao, F. Sundler & R. Håkanson: Acute responses of rat stomach enterochromaffinlike cells to gastrin: Secretory activation and adaptation. Gastroenterology 1994, 107, 18-27.
8. Chen, D., C.-M. Zhao, A.-G. Nylander & R. Håkanson: Time course of hypertrophic and ultrastructural responses of rat stomach enterochromaffin-like cells to sustained hypergastrinemia. Cell Tissue Res. 1996, 284, 55-63.
9. Chiba, T., Y. Kinoshita, T. Morishita, H. Nakata, A Nakamura & S. Hosoda: Receptors for gastrin on gastric carcinoid tumor membranes of Mastomys natalensis. Biochem. Biophys. Res. Commun. 1991, 177, 739-744.
10. Dimaline R & A. K. Sandvik: Histidine decarboxylase gene expression in rat fundus is regulated by gastrin. FEBS 1991, 28, 20-22.
11. Dimaline, R., D. Evans, E. R. Forster, A. K. Sandvik & G. J. Dockray: Control of gastric corpus chromogranin A messenger RNA abundance in the rat. Amer. J. Physiol. 1993, 264, G583-588.
12. Ding, X-Q., D. Chen & R. Håkanson: Cholecystokinin-B receptor ligands of the dipeptoids series act as agonists on rat stomach histidine decarboxylase. Gastroenterology 1995, 109, 1181-1187.
13. Ding, X.-Q. & R. Håkanson: Evaluation of potency and specificity of a series of cholecystokinin-B/gastrin receptor antagonists. Pharmacology & Toxicology 1996a, 79, 124-130.
14. Ding, X.-Q & R. Håkanson: Cholecystokinin-B/gastrin receptor blockade on gastric acid secretion in conscious rats. Pharmacology & Toxicology 1996b 79, 324-330.
15. Eissele, R., H. Patberg, H. Koop, W. Krack, W. Lorenz, A. T. Mcknight & R. Arnold: Effect of gastrin receptor blockade on endocrine cells in rat during achlorhydria. Gastroenterology 1992, 103, 1596-1601.
16. Håkanson R., Y. Tielemans, D. Chen, K. Andersson, B. Ryberg, H. Mattsson & F. Sundler: The biology and pathobiology of the ECL cells. Yale J. Biol. Med. 1992, 65, 761-764.
17. Håkanson R., Y. Tielemans, D. Chen, K. Andersson, H. Mattsson & F. Sundler: Time-dependent changes in enterochromaffin-like cell kinetics in stomach of hypergastrinemic rats. Gastroenterology 1993, 105, 15-21.
18. Håkanson, R., D. Chen & F. Sundler: The ECL cells. In: Physiology of the gastrointestinal tract. Vol. 2. Ed.: L. R. Johnson. Raven Press, New York, 1994, p. 1171-1184.
19. Håkanson, R. X.-Q., Ding, P. Norlén & D. Chen: Circulating pancreastatin is a marker for the enterochromaffin-like cells of the rat stomach. Gastroenterology 1995, 108, 1445-1452.
20. Innis, R. B & S. H. Snyder: Distinct cholecystokinin receptors in brain and pancreas. Proc. Natl. Acad. Sci. USA 1980, 77, 6917-6928.
21. Kawabata, S., S. Kanayama, Y. Shinomura, Y. Miyazaki, I. Imamura, K. Moriwaki, H. Wada & S. Tarui: Effect of cholecystokinin receptor antagonists, MK-329 and L-365,260 on cholecystokinin-induced acid secretion and histidine decarboxylase activity in the rat. Regul. Pept. 1991, 35, 1-10.
22. Kimura, K., D. Chen, E. Lindström, C.-M. Zhao & R. Håkanson: Evidence that rat stomach ECL cells represent the main source of circulating pancreastatin. Regul. Pept. 1997, 68, 177-180.
23. Kopin, A. S., Y.-M. Lee, L. J. McBride, E. W. Miller, M. Lu, H. Y. Lin, L. F. Kolakowski & M. Beinborn: Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc. Natl. Acad. Sci. USA 1992, 89, 3605-3609.
24. Larsson, H., E. Carlsson, H. Mattsson, L. Lundell, F. Sundler, G. Sundell, B. Wallmark, T. Watanabe & R. Håkanson: Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 1986, 90, 391-399.
25. Monstein, H.-J., A.-G. Nylander & D. Chen: RNA extraction from gastrointestinal tract and pancreas by a modified Chomczynski and Sacchi method. Bio. Techn. 1995, 19, 340-343.
26. Nishida, A., K. Miyata, R. Tsutsumi, H. Yuki, S. Akuzawa, A. Kobayashi, T. Kamato, H. Ito, M. Yamano, Y. Katuyama, M. Satoh, M. Ohta & K. Honda: Pharmacological profile of (R)-1-[2,3 dihydro-1-(2′-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3- (3-methylphenyl) urea (YM022), a new potent and selective gastrin cholecystokinin-B receptor antagonist, in vitro and in vivo. J. Pharmacol. Exp. Therap. 1994, 269, 725-731.
27. Nishida, A., A. Kobayashi-Uchida, S. Akuzawa, Y. Takinami, T. Shishido, T. Kamato, H. Ito, M. Yamano, H. Yuki, Y. Nagakura, K. Honda & K. Miyata: Gastrin receptor antagonist YM022 prevents hypersecretion after long term acid suppression. Amer. J. Physiol. 1995, 269, G699-G705.
28. Pendley, C. E., L. R. Fitzpatrick, A. J. Capolino, M. A. Davis, N. J. Esterline, A. Jakubowska, P. Bertrand, C. Guyon, M.-C. Dubroeucq & G. E. Martin: RP73870, a gastrin cholecystokinin-B receptor antagonist with potent anti-ulcer activity in the rat. J. Pharmacol. Exp. Therap. 1995, 273, 1015-1022.
29. Prinz, C., M. Kajimura, D. R. Scott, F. Mercier, H. F. Helander & G. Sachs: Histamine release from rat enterochromaffin-like cells. Gastroenterology 1993, 105, 449-461.
30. Prinz, C., D. R. Scott, D. Hurwitz, H. F. Helander & G. Sachs: Gastrin effects on isolated rat enterochromaffin-like cells in primary culture. Amer. J. Physiol. 1994, 267, G663-672.
31. Roche, S., T. Gusdinar, J.-P. Bali & R. Magous: "Gastrin" and "CCK" receptors on histamine-and somatostatin-containing cells from rabbit fundic mucosa. I. Characterization by means of agonists. Biochem. Pharmacol. 1991a, 42, 765-770.
32. Roche, S., T. Gusdinar, J.-P. Bali & R. Magous: "Gastrin" and "CCK" receptors on histamine-and somatostatin-containing cells from rabbit fundic mucosa. II. Characterization by means of selective antagonists L-364,718 and L-365,260. Biochem. Pharmacol. 1991b, 42, 771-776.
33. Rönnberg, A. L. & R. Håkanson: A simplified procedure for fluorometric determination of histamine in rat stomach. Agents Actions 1984, 14, 195-199.
34. Ryberg, B., J. Axelson, E. Carlsson, R. Håkanson, F. Sundler & H. Mattsson: Correlation between inhibition of gastric acid secretion, plasma gastrin and oxyntic mucosal histidine decarboxylase activity in the rat. Scand. J. Gastroenterol. 1989, 24, 287-292.
35. Sandvik, A. K & H. L. Waldum: CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion. Amer. J. Physiol. 1991, 260, G925-928.
36. Schmassmann, A., A. Garner, B. Flogerzi, M. Y. Hasan, M. Sanner, L. Varga & F. Halter: Cholecystokinin type B receptor antagonist PD136,450 is a partial agonist in stomach and full agonist in the pancreas of the rat. Gut 1994, 35, 270-274.
37. Stadil, F & J. F. Rehfeld: Determination of serum gastrin. An evaluation of the reliability of a radioimmunoassay. Scand. J. Gastroenterol. 1973, 8, 101-112.
38. Waldum, H. L., A. K. Sandvik, E. Brenna & H. Petersen: The gastrin-histamine sequence in the regulation of gastric acid secretion. Gut 1991, 32, 698-700.
39. Wank, S. A., R. Harkins, R. T. Jensen, H. Shapira, A. D. Weerth & T. Slattery: Purification, molecular cloning, and functional expression of the cholecystokinin receptor from rat pancreas. Proc. Natl. Acad. Sci. USA 1992a, 89, 3125-3129.
40. Wank, S. A., J. R. Pisegna & A. D. Weerth: Brain and gastrointestinal cholecystokinin receptor family: Structure and functional expression. Proc. Natl. Acad. Sci. USA. 1992b, 89, 8691-8695.