Osteoprotegerin: A novel local player in bone metabolism

European Journal of Endocrinology

Volumn 137, Issue 4, 1997, Pages 345-346

  Hofbauer, Lorenz C ^a   Heufelder, Armin E ^b  

^a MAYO CLINIC   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COLONY STIMULATING FACTOR 1; CYTOKINE; GLYCOPROTEIN; INTERLEUKIN 1; INTERLEUKIN 11; INTERLEUKIN 6; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ALBERS SCHOENBERG DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BONE DEVELOPMENT; BONE METABOLISM; BONE REMODELING; CELL DIFFERENTIATION; CHONDROSARCOMA; CHROMOSOME 8Q; CONTROLLED STUDY; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOPOROSIS; PRIORITY JOURNAL; RAT; SHORT SURVEY;

ANIMALS; BONE AND BONES; BONE REMODELING; GLYCOPROTEINS; HUMANS; OSTEOPROTEGERIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 0030869237     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1370345     Document Type: Short Survey

References (12)

1. Manolagos SC & Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. New England Journal of Medicine 1995 332 305-311.
2. Raisz LG. Local and systemic factors in the pathogenesis of osteoporosis. New England Journal of Medicine 1988 318 318-328.
3. Mundy GR. Cytokines and growth factors in the regulation of bone remodeling. Journal of Bone and Mineral Research 1993 8 (Suppl 2) S505-S510.
4. Bertolini DR, Nedwin GE, Bringman TS, Smith DD & Mundy GR. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factors. Nature 1986 319 516-518.
5. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 1992 257 88-91.
6. Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA et al. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor, Journal of Clinical Investigation 1995 95 2886-2895.
7. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang M-S, Lüthy R et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997 89 309-319.
8. Smith CA, Farrah T & Goodwin RG. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 1994 76 959-962.
9. Schreiber M, Rajarathnam K & McFadden G. Myxoma virus T2 protein, a tumor necrosis factor (TNF) receptor homolog, is secreted by a monomer and dimer that each bind rabbit TNFα but the dimer is a more potent TNF inhibitor. Journal of Biological Chemistry 1996 271 13333-13341.
10. Ammann P, Rizzoli R, Bonjour J-P, Bourrin S, Meyer J-M, Vassalli P et al. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. Journal of Clinical Investigation 1997 99 1699-1703.
11. Kimble RB, Bain S & Pacifici R. The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. Journal of Bone and Mineral Research 1997 12 935-941.
12. Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD et al. Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP 3. Geromics 1991 9 283-289.