Mechanism of action of fotemustine, a new chloroethylnitrosourea anticancer agent: Evidence for the formation of two DNA-reactive intermediates contributing to cytotoxicity

Biochemistry

Volumn 36, Issue 35, 1997, Pages 10646-10654

  Hayes, Mark T ^a,b,c   Bartley, John ^b   Parsons, Peter G ^c   Eaglesham, Geoff K ^d   Prakash, Arungundrum S ^a  

^a University of Queensland and Queensland Alliance for Environmental Health Sciences   (Australia)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d DEPARTMENT OF EMPLOYMENT ECONOMIC DEVELOPMENT AND INNOVATION   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROETHYLNITROSOUREA; DNA FRAGMENT; FOTEMUSTINE;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL KILLING; CYTOTOXICITY; DNA CROSS LINKING; DNA SEQUENCE; DRUG ACTIVITY; EXCISION; MASS SPECTROMETRY; PRIORITY JOURNAL; SPECIES DIFFERENTIATION; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DNA ADDUCTS; DNA METHYLATION; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; GUANINE; HELA CELLS; HUMANS; MASS SPECTROMETRY; MELANOMA; NITROSOUREA COMPOUNDS; ORGANOPHOSPHORUS COMPOUNDS; TUMOR CELLS, CULTURED;

EID: 0030868927     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970791q     Document Type: Article

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