Reaction of N-(2-chloroethyl)-N-nitrosoureas with DNA: Effect of buffers on DNA adduction, cross-linking, and cytotoxicity

Chemical Research in Toxicology

Volumn 9, Issue 1, 1996, Pages 208-214

  Chen, Fa Xian ^a   Bodell, William J ^b   Liang, Gangning ^a   Gold, Barry ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 HYDROXYETHYL) 1 NITROSOUREA; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CARMUSTINE; CHLOROETHYLNITROSOUREA DERIVATIVE; DEOXYGUANOSINE DERIVATIVE; DNA FRAGMENT; LOMUSTINE; METHYLNITROSOUREA; NITROSOUREA DERIVATIVE; RANIMUSTINE; TROMETAMOL; UNCLASSIFIED DRUG;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; DNA ALKYLATION; DNA CROSS LINKING; DNA DAMAGE; DNA MODIFICATION; DOSE RESPONSE; DRUG DNA INTERACTION; DRUG STRUCTURE; LEUKEMIA L 1210; REACTION ANALYSIS; RESTRICTION FRAGMENT;

ALKYLATION; ANIMALS; BASE SEQUENCE; CROSS-LINKING REAGENTS; DNA ADDUCTS; DNA DAMAGE; DRUG INTERACTIONS; ETHYLNITROSOUREA; LEUKEMIA L1210; MICE; TROMETHAMINE;

EID: 0030051757     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx950097g     Document Type: Article

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