Update: Antiphospholipid antibodies

Journal of Clinical Rheumatology

Volumn 3, Issue 5, 1997, Pages 270-278

  Sammaritano, Lisa R ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Anticardiolipin antibodies; Antiphospholipid antibodies; Antiphospholipid syndrome; Lupus anticoagulant

Indexed keywords

ACETYLSALICYLIC ACID; AUTOANTIBODY; AZATHIOPRINE; BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; CORTICOSTEROID; DANAZOL; EPITOPE; HEPARIN; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 3; LUPUS ANTICOAGULANT; PHOSPHOLIPID; PHOSPHOLIPID ANTIBODY; PHOSPHOLIPID BINDING PROTEIN; PREDNISONE; PROCAINAMIDE; PROTEIN C; PROTEIN S; REAGINIC ANTIBODY; THROMBOMODULIN; WARFARIN;

ANTICOAGULATION; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; AVASCULAR NECROSIS; BLOOD VESSEL OCCLUSION; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS WASTAGE; HELLP SYNDROME; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FAILURE; NEUROLOGIC DISEASE; NONHUMAN; PLASMAPHERESIS; PREECLAMPSIA; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA; THROMBOSIS;

EID: 0030868005     PISSN: 10761608     EISSN: None     Source Type: Journal    
DOI: 10.1097/00124743-199710000-00006     Document Type: Article

References (75)

1. Wassermann A, Neisscr A, Brück C. Eine serodiagnostiche reaktion bei syphilis. Dtsch Med Wochenschr 1906;32:745.
2. Conley CL, Hartmann RC. A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J Lab Clin Invest 1952;31:621-2.
3. Harris EN, Gharavi AE, Boey ML, Patel BM, Mackworth-Young CG, Loizou S, et al. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983; ii:1211-4.
4. Asherson RA, Cer\-era R, Pielte JC, Shoenfeld Y. The antiphospholipid syndrome: history, definition, classification, and differential diagnosis. In: Asherson RA, Cervera R, Piette JC,
5. Shocnfcld Y, editors. The antiphospholipid syndrome. Boca Raton: CRC Press; 1996. p. 3-12.
6. Pengo V, Thiagarajan P, Shapiro SS, Heine MJ. Immunological specificity and mechanism of action of IgG lupus anticoagulants. Blood 1987;70:69-74.
7. McNeil HP, Chesterman CN, Krilis SA. Anticardiolipin and lupus anticoagulants comprise separate antibody subgroups with different phospholipid binding characteristics. Br J Haematol 19S9;73:506-12.
8. Exner T, Sahman N, Trudinger B. Separation . of anticardiolipin antibodies from lupus anticoagulant on a phospholipid-coated polystyrene column. Biochem Biophys Res Commun 1988;155:1001-5.
9. Prieto J, Yuste JR, Beloqui O, Civeira MP, Riezu JI, Aguirre B, et al. Anticardiolipin antibodies in hepatitis C virus as the cause of the antiphospholipid syndrome. Hepatology 1996; 23:199-204.
10. Levy RA, Gharavi AE, Sammaritano LR, Habina L, Qamar T, Lockshin MD. Characteristics of IgG antiphospholipid antibodies in patients with SLE and syphilis. J Rheumatol 1990;171:1036-41.
11. McNeil HP, Simpson RJ, Ch'esterman CN, Krilis SA. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci U S A 1990;87:4120-5.
12. Lozier J, Takahashi N, Putnam FW. Complete amino acid sequence of human plasma beta 2glycoprotein 1. Proc Natl Acad Sci U S A1984; 40:3640-5.
13. Schousboe I. Beta 2-glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood 1985;66: 1086-92.
14. Hunt JE, Simpson RJ, Krilis SA. Identification of a region of beta2-glycoprotein I critical for lipid binding and anticardiolipin cofactor activity. Proc Natl Acad Sci U S A 1993;90: 2141-S.
15. Hunt JE, Krilis SA. The fifth domain of beta2-glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies. J Immunol 1994;152:653-61.
16. Costing JD, Derkson RHVVM, Bobbink IW, Hackeng TM, Bouma BN, deGroot PG. Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism? Blood 1993;81: 2618-25.
17. Cariou R, Tobelem G, Bellucci S, Soria C, Maclouf J, Caen J. Effect of lupus anticoagulant on antithrombogenic properties of endothelial cells -inhibition of thrombomodulin-dependent protein C activation. Thromb Haemost 1988;60:54-9.
18. Simantov R, LaSala JM, Lo SK, Gharavi AE, Sammaritano LR, Salmon JE, et al. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J Clin Invest 1995,-96: 2211-9.
19. Gharavi AE, Mellors RC, Elkon KB. IgG anticardiolipin antibodies in murine lupus. Clin Exp Immunol 1989;78:233-8.
20. Hashimoto Y, Kawamura M, Ichikawa K, Suzuki T, Sumida T, Yoshida S, et al. Anticardiolipin antibodies in NZW X BXSB Fl mice. J Immunol 1992;149:1063-S.
21. Branch DW, Dudley DJ, Mitchell MD, Creighton KA, Abbott TM, Hammond EH, et al. Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in Balb/c mice: a model for autoimmune fetal loss. Am J Obstet Gynecol 1990: 163:210-6.
22. Pierangeli S, Harris EN. Antiphospholipid antibodies in an in vivo thrombosis model in mice. Lupus 19943:247-51.
23. Bakimer R, Fishman P, Blank M, Sredni B, Djaldetti M, Shoenfeld Y. Induction of primary antiphospholipid antibody syndrome in mice by immunization with a human monoclonal antibody (H3). J Clin Invest 1992;89: 1558-63.
24. Gharavi AE, Sammaritano LR, Wen J, Elkon KB. Induction of antiphospholipid autoantibodies by immunization with beta2-glycoprotein I (apolipiprotein H). J Clin Invest 1993;93: 269-72.
25. Tincani A, Shoenfeld Y. Animal models of the antiphospholipid syndrome. In: Asherson RA, Cervera R, Piette JC, Shoenfeld Y, editors. The antiphospholipid syndrome. Boca Raton: CRC Press; 1996. p. 71-82.
26. Mathey F, Walshe K, Mackie IJ, Machin SJ. Familial occurrence of the antiphospholipid syndrome. J Clin Pathol 1989;42:495-7.
27. Mackworth-Young C, Chan C, Harris N, VValport M, Bernstein R, Batchelor R, et al. High incidence of anlicardiolipin antibodies in relatives of patients with systemic lupus erythematosus. J Rheumatol 1987;14:723-6.
28. Sammaritano LR. Pédiatrie and familial antiphospholipid syndromes. In: Asherson RA, Cervera R, Piette JC, Shoenfeld Y, editors. The antiphospholipid syndrome. Boca Raton: CRC Press; 1996. p. 259-66.
29. Sebastian! GD, Passiu G, Galeazzi M, Carcassi U. Prevalence and clinical associations of anticardiolipin antibodies in systemic lupus: a prospective study. Clin Rheumatol 1991;10: 289-93.
30. Worrall JG, Snaith ML, Batchelor JR, Isenberg DA. SLE: a rheumatologic view. Analysis of the clinical features, serology, and immunogenetics of 100 SLE patients during long-term follow-up. Q J Med 1990;74:319-30.
31. Ginsberg KS, Liang MH, Newcomer L, Goldhaber SZ, Schur PH, Hennekens CH, et al. Anticardiolipin antibodies and the risk for ischémie stroke and venous thrombosis. Ann Intern Med 1992;117:997-1002.
32. Pétri M. Epidemiology of the antiphospholipid syndrome. In: Asherson RA, Cervera R, Piettte JC, Shoenfeld Y, editors. The antiphospholipid syndrome. Boca Raton: CRC Press; 1996. p. 13-28.
33. The Antiphospholipid Antibodies in Stroke Study (APASS) Group. Anticardiolipin antibodies are an independent risk factor for first ischémie stroke. Neurology 1993;43:2069-73.
34. Finazzi G, Brancaccio V, Moia M, Ciavarella N, Mazzucconi MG, Schinco PC, et al. Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies: a four-year prospective study from the Italian registry. Am J Med 1996;100:530-6.
35. Hart RG, Miller VT, Coull BM, Bril V. Cerebral infarction associated with lupus anticoagulants -preliminary report. Stroke 1984;15: 114.
36. Asherson RA, Khamashta MA, Gil A, Vazquez JJ, Chan O, Baguley E, et al. Cerebrovascular disease and antiphospholipid an-tibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome. Am J Med 1989;86:391-9.
37. Love PE, Santoro SA. Anliphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus crythematosus (SLE) and in non-SLE disorders. Ann Intern Med 1990;112:682-98.
38. Arnason JA, Graziano FM. Adrenal insufficiency in the antiphospholipid syndrome. Semin Arthritis Rheum 1995;25:109-16.
39. Lockwood CJ, Romero R, Feinberg RF, Clyne LP, Coster B, Bobbins JC. The prevalence and biologic significance of lupus anticoagulant and anticardiolipin antibodies in a general obstetric population. Am J Obstet Gynecol 1989;161:369-73.
40. Deleze M, Alarcon-Segovia D, Valdes-Macho E, Oria CV, Ponce de Leon S. Relationship between antiphospholipid antibodies and recurrent fetal loss in patients with systemic lupus erythematosus and apparently healthy women. J Rheumatol 1989;!6:768-72.
41. Lockshin MD, Druzin ML, Goei S, Qamar T, Magid MS, Jovanovic L, et al. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med 1985;13:152-6.
42. Branch DVV, Scott JR, Kochenour NK, Hershgold E. Obstetric complications associated with the lupus anticoagulant. N Engl J Med 1985;13:1322-6.
43. Kwak JY, Barini R, Gilman-Sachs A, Beaman KD, Beer AE. Down regulation of maternal antiphospholipid antibodies during early pregnancy and pregnancy outcome. Am J Obstet Gynecol 1994;!71:239-46.
44. Sthoeger ZM, Mozes E, Tarta Kovsky B. Anticardiolipin antibodies induce pregnancy failure by impairing embryonic implantation. Proc Natl Acad Sci U S A 1993,-90:6464-7.
45. Sher G, Feinman M, Zouves C, Kuttner G, Maassarani G, Salem R, et al. High fecundity rates following in vitro fertilization and embryo transfer in antiphospholipid antibody sé ropositive women treated with aspirin and heparin. Hum Reprod 1994;9:2278-83.
46. Branch D\V, Andres R, Digre KB, Rote NS, Scott JR. The association of antiphospholipid antibodies with severe preeclampsia. Obstet Gynecol 1989;73:541-3.
47. Ornstein MH, Rand JH. An association between refractory HELLP syndrome and antiphospholipid antibodies during pregnancy: a report of two cases. J Rheumatol 1994;21:13604.
48. Alsulyman OM, Castro MA, Zuckerman E, McGehee W, Goodwin TM. Preeclampsia and liver infarction in early pregnancy associated with the antiphospholipid syndrome. Obstet Gynecol 1996;88:644-6.
49. Smith JB, Cowchock FS. Antiphospholipid antibodies: clinical and laboratory considerations, pathophysiology and treatment. Immunol Allergy Clin 1994;14:821-34.
50. Hazeltine M, Rauch J, Danoff D, Esdaile JM, Tannenbaum H. Antiphospholipid antibodies in systemic lupus erythematosus: evidence of an association with positive Coombs' and hypocomplementemia. J Rheumatol 1988;15:80-6.
51. Nesher G, Hanna VE, Moore TL, Hersh M, Osbom TG. Thrombotic microangiopathic hemolytic anemia in systemic lupus erythematosus. Semin Arthritis Rheum 1994; 24:165-72.
52. Asherson RA, Piette JC, Cervera R. "Primary," "secondary," "catastrophic," and other variants of the antiphospholipid syndrome. In: Asherson RA, Cervera R, Piette JC, Shoenfeld Y, editors. The antiphospholipid syndrome. Boca Raton: CRC Press; 1996. p. 249-57.
53. Grob ]], Bonerandi JJ. Thrombotic skin disease as a marker of the anticardiolipin syndrome: livedo reticularis and distal gangrene associated with abnormal serum antiphospholipid activity. J Am Acad Dermatol 198920:1063-9.
54. Weinstein C, Miller MH, Axtens R, Buchanan R, Littlejohn GO. Livedo reticularis associated with increased tilers of anticardiolipin antibodies in systemic lupus eiythematosus. Arch Dermatol 1987;123:596-600.
55. Briley DP, Coull BM, Goodnight SH. Neurological disease associated with antiphospholipid antibodies. Ann Neurol 1989;25:221-7.
56. Brey RL, Escalante A, Futrell N, Asherson RA. Cerebral thrombosis and other neurological manifestations in the antiphospholipid syndrome. In: Asherson RA, Cervera R, Piette JC, Shoenfeld Y, editors. The antiphospholipid syndrome. Boca Raton: CRC Press; 1996. p. 133-50.
57. Kincaid-Smith P, Fairley FK, Kloss M. Lupus anticoagulant associated with renal thrombotic microangiopathy and pregnancy-related renal failure. Q J Med 1988;69:795-815.
58. Amigo MC, Carcia-Torres R, Robles M, Bochicchio T, Reyes PA. Renal involvement in primary antiphospholipid syndrome. J Rheumatol 1992;19:1181-5.
59. Hamsten A, Norberg R, Bjorkholm M, de Faire U, Holm G. Antibodies to cardiolipin in young survivors of myocardial infarction: an association with recurrent cardiovascular events. Lancet 1986;i:113-6.
60. Morten KE, Gavaghan TP, Krilis SA, Daggard GE, Baron DW, Hickie JB, et al. Coronary artery bypass graft failure -an autoimmune phenomenon. Lancet 1986;ii:l353-7.
61. Leventhal LJ, Borofsky MA, Bergey PD, Schumacher HR Jr. Antiphospholipid antibody syndrome with right atrial thrombosis mimicking an atrial myxoma. Am J Med 1989; 87:111-3.
62. Chartash EK, Lans DM, Paget SA, Qamar T, Lockshin MD. Aortic insufficiency and mitral régurgitation in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Am J Mod 1989;86:406-12.
63. Leung VVH, \Vong KL, Lau CP, Wong CK. Association between antiphospholipid antibodies and cardiac abnormalities in patients with systemic lupus erythematosus. Am J Med 1990;S9:411-9.
64. Cervera R, Khamashta MA, Font J, Reyes PA, Vianna JL, Lopez-Soto A, et al. High prevalence of significant heart valve lesions in patients with the 'primary1 antiphospholipid syndrome. Lupus 1991;l:43-7.
65. Asherson RA, Liote F, Page B, Meyer O, Buchanan N, Khamashta MA, et al. Avascular necrosis of bone and antiphospholipid antibodies in systemic lupus erythematosus. J Rheumatol 199320:284-8.
66. Harris EN, Bos K. An acute disseminated coagulopathy -vasculopathy associated with the antiphospholipid syndrome. Arch Intern Med 1991;151:231-3.
67. Asherson RA. The catastrophic antiphospholipid syndrome. J Rheumatol 1992;!9:508-12.
68. Asherson RA, Khamashta MA, Ordi-Ros J, Derkson RHWM, Machin SJ, Barquinero J, et al. The "primary" antiphospholipid syndrome: major clinical and serological features. Medicine 1989;68:366-74.
69. Rosove MH, Brewer PMC. Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients. Ann Intern Med 1992;117:303-8.
70. Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GRV. The management of thrombosis in the antiphospholipid-antibody syndrome. N Engl J Med 1995;332:9937.
71. Alarcon-Segovia D, Sanchez-Guerrero J. Correction of thrombocytopenia with small dose aspirin in the primary antiphospholipid syndrome. J Rheumatol 19S9;16:1359-61.
72. Kavanaugh A. Danazol therapy in thrombocytopenia associated with the antiphospholipid antibody syndrome. Ann Intern Med 1994; 121:7677-8.
73. Cowchock FS, Reece EA, Balaban D, Branch DW, Plouffe L. Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low dose heparin treatment. Am J Obstet Gynecol 1992;166:1318-23.
74. Rai RS, Regan L, Dave M, Cohen H. Randomized controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997314:253-7.
75. Spinnato JA, Clark AL, Pierangeli SS, Harris EN. Intravenous immunoglobulin therapy for the antiphospholipid syndrome in pregnancy. Am J Obstet Gynecol 1995;172:69(M.