메뉴 건너뛰기




Volumn 15, Issue 2, 1997, Pages 122-136

EXP3174: The major active metabolite of losartan

Author keywords

Angiotensin II type 1 receptor antagonist; EXP3174; Losartan

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR; CYTOCHROME P450; DRUG METABOLITE; LOSARTAN; RECEPTOR SUBTYPE;

EID: 0030864553     PISSN: 08975957     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1527-3466.1997.tb00327.x     Document Type: Review
Times cited : (17)

References (70)
  • 1
    • 0017109624 scopus 로고
    • Effect of angiotensin II antagonist infusion on autoregulation of renal blood flow
    • Abe Y, Kishimoto T, Yamamoto K, Effect of angiotensin II antagonist infusion on autoregulation of renal blood flow. Am J Physiol 1976;231:1267-1271.
    • (1976) Am J Physiol , vol.231 , pp. 1267-1271
    • Abe, Y.1    Kishimoto, T.2    Yamamoto, K.3
  • 2
    • 0028934394 scopus 로고
    • Effect of acute and chronic treatment with the angiotensin II subtype 1 receptor antagonist EXP3174 on baroreflex function in conscious spontaneously hypertensive rats
    • Bartholomeusz B, Widdop R. Effect of acute and chronic treatment with the angiotensin II subtype 1 receptor antagonist EXP3174 on baroreflex function in conscious spontaneously hypertensive rats. J Hypertens 1995;13:219-225.
    • (1995) J Hypertens , vol.13 , pp. 219-225
    • Bartholomeusz, B.1    Widdop, R.2
  • 3
    • 0028858757 scopus 로고
    • Effect of EXP3174 on blood pressure of normoreninemic renal hypertensive rats
    • Basso N, Kurnjek M, Ruiz P, Cannata M. Effect of EXP3174 on blood pressure of normoreninemic renal hypertensive rats. Hypertension 1995;25:283-287.
    • (1995) Hypertension , vol.25 , pp. 283-287
    • Basso, N.1    Kurnjek, M.2    Ruiz, P.3    Cannata, M.4
  • 4
    • 0029017714 scopus 로고
    • The angiotensin II type 1 receptor antagonists
    • Bauer J, Reams G. The angiotensin II type 1 receptor antagonists. Arch Intern Med 1995;155:1361-1368.
    • (1995) Arch Intern Med , vol.155 , pp. 1361-1368
    • Bauer, J.1    Reams, G.2
  • 6
    • 0026458342 scopus 로고
    • Effect of captopril and the nonpeptide angiotensin II antagonists, SK&F 108566 and EXP3174, on renal function in dogs with a renal artery stenosis
    • Brooks DP, DePalma PD, Ruffolo RR. Effect of captopril and the nonpeptide angiotensin II antagonists, SK&F 108566 and EXP3174, on renal function in dogs with a renal artery stenosis. J Pharmacol Exp Ther 1992;263:422-427.
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 422-427
    • Brooks, D.P.1    DePalma, P.D.2    Ruffolo, R.R.3
  • 7
    • 0025906857 scopus 로고
    • Nomenclature for angiotensin receptors: A report of the nomenclature committee of the council for high blood pressure research
    • Bumpus FM, Catt KJ, Chiu AT, et al. Nomenclature for angiotensin receptors: A report of the nomenclature committee of the council for high blood pressure research. Hypertension 1991;17:720-723.
    • (1991) Hypertension , vol.17 , pp. 720-723
    • Bumpus, F.M.1    Catt, K.J.2    Chiu, A.T.3
  • 8
    • 0003150944 scopus 로고
    • The angiotensin-converting enzyme: Molecular biology and implication of the gene polymorphism in cardiovascular diseases
    • Laragh J, Brenner B, eds. New York:Raven Press
    • Cambien F, Soubrier F. The angiotensin-converting enzyme: Molecular biology and implication of the gene polymorphism in cardiovascular diseases. In: Laragh J, Brenner B, eds. Hypertension: Pathophysiology, Diagnosis, and Management, New York:Raven Press, 1995:1667-1682.
    • (1995) Hypertension: Pathophysiology, Diagnosis, and Management , pp. 1667-1682
    • Cambien, F.1    Soubrier, F.2
  • 9
    • 0026690935 scopus 로고
    • In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist
    • Chang R, Siegl P, Clineschmidt B, et al. In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist. J Pharmacol Exp Ther 1992;262:133-138.
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 133-138
    • Chang, R.1    Siegl, P.2    Clineschmidt, B.3
  • 10
    • 0027380333 scopus 로고
    • Intrinsic properties of the nonpeptide angiotensin II antagonist losartan in glomeruli and mesangial cells at high concentrations
    • Chansel D, Badre L, Czekalski S, Vandermeersch S, Cambar J, Ardaillou R. Intrinsic properties of the nonpeptide angiotensin II antagonist losartan in glomeruli and mesangial cells at high concentrations. J Pharmacol Exp Ther 1993;265:1534-1543.
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 1534-1543
    • Chansel, D.1    Badre, L.2    Czekalski, S.3    Vandermeersch, S.4    Cambar, J.5    Ardaillou, R.6
  • 11
    • 0025305205 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP753, an orally active andhypertensive agent
    • Chiu AT, McCall DE, Price WA, et al. Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP753, an orally active andhypertensive agent. J Pharmacol Exp Ther 1990;252:711-718.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 711-718
    • Chiu, A.T.1    McCall, D.E.2    Price, W.A.3
  • 12
    • 0029068526 scopus 로고
    • Human plasma protein binding of the angiotensin EE receptor antagonist losartan potassium (Dup753/MK954) and its pharmacologically active metabolite EXP3174
    • Christ D. Human plasma protein binding of the angiotensin EE receptor antagonist losartan potassium (Dup753/MK954) and its pharmacologically active metabolite EXP3174. J Clin Pharamacol 1995;35:515-520.
    • (1995) J Clin Pharamacol , vol.35 , pp. 515-520
    • Christ, D.1
  • 13
    • 0346922436 scopus 로고
    • Pharmacokinetics of the novel angiotensin II receptor antagonist DuP753 in dogs
    • Christ D, Wong N, Lam G, Quon C. Pharmacokinetics of the novel angiotensin II receptor antagonist DuP753 in dogs. FASEB J 1990;4:A462.
    • (1990) FASEB J , vol.4
    • Christ, D.1    Wong, N.2    Lam, G.3    Quon, C.4
  • 14
    • 0028202482 scopus 로고
    • The pharmacokinetics and pharmacodynamics of the angiotensin II receptor antagonist losartan potassium (Dup753/MK954) in the dog
    • Christ DD, Wong PC, Wong YN, Hart SD, Quon CY, Lam GN. The pharmacokinetics and pharmacodynamics of the angiotensin II receptor antagonist losartan potassium (Dup753/MK954) in the dog. J Pharmacol Exp Ther 1994;268:1199-1205.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1199-1205
    • Christ, D.D.1    Wong, P.C.2    Wong, Y.N.3    Hart, S.D.4    Quon, C.Y.5    Lam, G.N.6
  • 15
    • 0025858964 scopus 로고
    • Oral administration of Dup753, a specific angiotensin II receptor antagonist, to normal male volunteers inhibition of pressor response to exogenous angiotensin I and II
    • Christen Y, Waeber B, Nussberger J, et al. Oral administration of Dup753, a specific angiotensin II receptor antagonist, to normal male volunteers inhibition of pressor response to exogenous angiotensin I and II Circulation 1991;83:1333-1342.
    • (1991) Circulation , vol.83 , pp. 1333-1342
    • Christen, Y.1    Waeber, B.2    Nussberger, J.3
  • 16
    • 0028107956 scopus 로고
    • BMS-1080560, an insurmoutable inhibitor of angiotensin II-stimulated responses: Comparison with losartan and EXP3174
    • Dickinson K, Cohen R, Skwish S, et al. BMS-1080560, an insurmoutable inhibitor of angiotensin II-stimulated responses: Comparison with losartan and EXP3174. Br J Pharmacol 1994;113:379-189.
    • (1994) Br J Pharmacol , vol.113 , pp. 379-1189
    • Dickinson, K.1    Cohen, R.2    Skwish, S.3
  • 17
    • 0029925086 scopus 로고    scopus 로고
    • Interaction of nonpeptide angiotensin II receptor antagonists with the urate transporter in rat renal brush-border membranes
    • Edwards R, Trizna W, Stack E, Weinstock J. Interaction of nonpeptide angiotensin II receptor antagonists with the urate transporter in rat renal brush-border membranes. J Pharmacol Exp Ther 1996;276:125-129.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 125-129
    • Edwards, R.1    Trizna, W.2    Stack, E.3    Weinstock, J.4
  • 18
    • 0025991435 scopus 로고
    • Effect of an angiotensin II and a kinin receptor antagonist on the renal hemodynamic response to captopril
    • Fenoy FJ, Scicli G, Carretero O, Roman RJ. Effect of an angiotensin II and a kinin receptor antagonist on the renal hemodynamic response to captopril. Hypertension 1991;17:1038-1044.
    • (1991) Hypertension , vol.17 , pp. 1038-1044
    • Fenoy, F.J.1    Scicli, G.2    Carretero, O.3    Roman, R.J.4
  • 19
    • 0026515879 scopus 로고
    • Simultaneous determination of a novel angiotensin II receptor blocking agent, losartan, and its metabolite in human plasma and urine by high performance liquid chromatography
    • Furtek C, Lo M. Simultaneous determination of a novel angiotensin II receptor blocking agent, losartan, and its metabolite in human plasma and urine by high performance liquid chromatography. J Chromato 1992; 573:295-301.
    • (1992) J Chromato , vol.573 , pp. 295-301
    • Furtek, C.1    Lo, M.2
  • 20
    • 9844263597 scopus 로고    scopus 로고
    • Jpn. Patent No. 56-71073, 71074 (1981); U.S. Pat. 4340598, 4355040 (1982)
    • Furukawa Y, Kishimoto S, Nishikawa K. Jpn. Patent No. 56-71073, 71074 (1981); U.S. Pat. 4340598, 4355040 (1982).
    • Furukawa, Y.1    Kishimoto, S.2    Nishikawa, K.3
  • 21
    • 9844269398 scopus 로고    scopus 로고
    • Jpn. Patent No. 58-157768 (1983); U.S. Pat. 504049 (1983)
    • Furukawa Y, Nishikawa K. Jpn. Patent No. 58-157768 (1983); U.S. Pat. 504049 (1983).
    • Furukawa, Y.1    Nishikawa, K.2
  • 22
    • 9844268337 scopus 로고
    • Sites of action benzothiazines, furosemide and ethacynic acid
    • Lant AJ, Wilson GM. eds. Amsterdam:Excepta Medica
    • Goldberg M, Beck LH, Puschett JB. Sites of action benzothiazines, furosemide and ethacynic acid. In: Lant AJ, Wilson GM. eds. Modern Diuretic Therapy. Amsterdam:Excepta Medica, 1973:135-147.
    • (1973) Modern Diuretic Therapy , pp. 135-147
    • Goldberg, M.1    Beck, L.H.2    Puschett, J.B.3
  • 24
    • 0029972753 scopus 로고    scopus 로고
    • Phenobarbital minimally alters plasma concentrations of losartan and its active metabolite E-3174
    • Goldberg M, Lo M, Deutsch P, Wilson S, McWilliams E, McCrea J. Phenobarbital minimally alters plasma concentrations of losartan and its active metabolite E-3174. Clin Pharmacol Ther 1996;59:268-274.
    • (1996) Clin Pharmacol Ther , vol.59 , pp. 268-274
    • Goldberg, M.1    Lo, M.2    Deutsch, P.3    Wilson, S.4    McWilliams, E.5    McCrea, J.6
  • 25
    • 0002436092 scopus 로고    scopus 로고
    • Vasoactive peptides and the kidney
    • Brenner B, ed. Philadelphia: W.B. Saunders
    • Gunning M, Ingelfinger J, King A, Brenner B. Vasoactive peptides and the kidney. In: Brenner B, ed. The Kidney. Philadelphia: W.B. Saunders, 1996:627-712.
    • (1996) The Kidney , pp. 627-712
    • Gunning, M.1    Ingelfinger, J.2    King, A.3    Brenner, B.4
  • 26
    • 0025804369 scopus 로고
    • Kinin contribution to renal vasodilator effect of captopril in rabbit
    • Hajj-ali AF, Zimmerman BG. Kinin contribution to renal vasodilator effect of captopril in rabbit. Hypertension 1991;17:504-509.
    • (1991) Hypertension , vol.17 , pp. 504-509
    • Hajj-ali, A.F.1    Zimmerman, B.G.2
  • 27
    • 0022500358 scopus 로고
    • Regulation of glomerular filtration rate and sodium excretion by angiotensin II
    • Hall JE. Regulation of glomerular filtration rate and sodium excretion by angiotensin II. FASEB J 1986; 45:1431-1437.
    • (1986) FASEB J , vol.45 , pp. 1431-1437
    • Hall, J.E.1
  • 28
    • 0022065404 scopus 로고
    • Tubular transport responses to angiotensin
    • Harris PJ, Navar LG. Tubular transport responses to angiotensin. Am J Physiol 1985;248:F621-F630.
    • (1985) Am J Physiol , vol.248
    • Harris, P.J.1    Navar, L.G.2
  • 29
    • 0029988760 scopus 로고    scopus 로고
    • Effects of the specific angiotensin EI receptor antagonist losartan on urate homeostasis and intestinal urate transport
    • Hatch M, Freel R, Shahinfar F, Vaziri N. Effects of the specific angiotensin EI receptor antagonist losartan on urate homeostasis and intestinal urate transport. J Pharmacol Exp Ther 1996;276:187-193.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 187-193
    • Hatch, M.1    Freel, R.2    Shahinfar, F.3    Vaziri, N.4
  • 31
    • 0026077306 scopus 로고
    • Angiotensin actions in the kidney: Renewed insight into the old hormone
    • Ichikawa I. Angiotensin actions in the kidney: Renewed insight into the old hormone. Kidney Im 1991;40: 583-596.
    • (1991) Kidney Im , vol.40 , pp. 583-596
    • Ichikawa, I.1
  • 32
    • 0028074660 scopus 로고
    • Inhibitory effect of the nonpeptide angiotensin II receptor antagonist losartan and its active metabolite, E-3174, on cAMP phosphodiesterase: Additional action of the antagonists
    • Ishizaki H, Ohtawa M. Inhibitory effect of the nonpeptide angiotensin II receptor antagonist losartan and its active metabolite, E-3174, on cAMP phosphodiesterase: Additional action of the antagonists. Biochem Pharmacol 1994;48:201-204.
    • (1994) Biochem Pharmacol , vol.48 , pp. 201-204
    • Ishizaki, H.1    Ohtawa, M.2
  • 33
    • 0002886046 scopus 로고    scopus 로고
    • Renin and angiotensin
    • Hardman J, Limbird L, Molinoff P, Ruddon R, Gilman A, eds. New York:McGraw-Hill
    • Jackson E, Garrison J. Renin and angiotensin. In: Hardman J, Limbird L, Molinoff P, Ruddon R, Gilman A, eds. The Pharmacological Basis of Therapeutics. New York:McGraw-Hill, 1996:733-758.
    • (1996) The Pharmacological Basis of Therapeutics , pp. 733-758
    • Jackson, E.1    Garrison, J.2
  • 34
    • 0029588499 scopus 로고
    • Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans
    • Lo M, Goldberg M, McCrea J, Lu H, Furtek C, Bjornsson T. Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans. Clin Pharmacol Ther 1995;58:641-649.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 641-649
    • Lo, M.1    Goldberg, M.2    McCrea, J.3    Lu, H.4    Furtek, C.5    Bjornsson, T.6
  • 35
    • 0026438921 scopus 로고
    • Inhibitory effects of DuP753 and EXP3174 on responses to angiotensin II in pulmonary vascular bed of the cat
    • McMahon T, Kaye A, Hood J, Minkes R, Nossaman B, Kadowitz P. Inhibitory effects of DuP753 and EXP3174 on responses to angiotensin II in pulmonary vascular bed of the cat. Appl Physiol 1992;73:2054-2061.
    • (1992) Appl Physiol , vol.73 , pp. 2054-2061
    • McMahon, T.1    Kaye, A.2    Hood, J.3    Minkes, R.4    Nossaman, B.5    Kadowitz, P.6
  • 36
    • 0026593853 scopus 로고
    • Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist
    • Munafo A, Christen Y, Nussberger J, et al. Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist. Clin Pharmacol Ther 1992;51: 513-521.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 513-521
    • Munafo, A.1    Christen, Y.2    Nussberger, J.3
  • 37
    • 0028908871 scopus 로고
    • Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist
    • Nagura J, Yasuda S, Fujishima K, et al. Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist. Eur J Pharmacol 1995;274:201-211.
    • (1995) Eur J Pharmacol , vol.274 , pp. 201-211
    • Nagura, J.1    Yasuda, S.2    Fujishima, K.3
  • 38
    • 0025062465 scopus 로고
    • Regulation of liver angiotensinogen and kidney renin mRNA levels by angiotensin II
    • Nakamura A, Iwao H, Fukui K, et al. Regulation of liver angiotensinogen and kidney renin mRNA levels by angiotensin II. Am J Physiol 1990;258:E1-E6.
    • (1990) Am J Physiol , vol.258
    • Nakamura, A.1    Iwao, H.2    Fukui, K.3
  • 39
    • 0026527261 scopus 로고
    • Pilot study of the uricosuric effect of DuP753, a new angiotensin II receptor antagonist, in healthy subjects
    • Nakashima M, Uematsu T, Kosuge K, Kanamura M. Pilot study of the uricosuric effect of DuP753, a new angiotensin II receptor antagonist, in healthy subjects. Eur J Clin Pharmacol 1992;42:333-335.
    • (1992) Eur J Clin Pharmacol , vol.42 , pp. 333-335
    • Nakashima, M.1    Uematsu, T.2    Kosuge, K.3    Kanamura, M.4
  • 40
    • 0025784590 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists: Pharmacological studies on imidazoleacetic acid derivatives
    • Nishikawa K, Shibouta Y, Inada Y, Terashita Z, Kawazoe K, Furukawa Y. Nonpeptide angiotensin II receptor antagonists: Pharmacological studies on imidazoleacetic acid derivatives. J Takeda Res Lab 1991; 50:75-98.
    • (1991) J Takeda Res Lab , vol.50 , pp. 75-98
    • Nishikawa, K.1    Shibouta, Y.2    Inada, Y.3    Terashita, Z.4    Kawazoe, K.5    Furukawa, Y.6
  • 41
    • 0026668349 scopus 로고
    • Effects of semotiadil fumarate (SD-3211) on renal hemodynamics and function in dogs
    • Nishiyama A, Tamaki T, Masumura H, et al. Effects of semotiadil fumarate (SD-3211) on renal hemodynamics and function in dogs. Eur J Pharmacol 1992;218:311-317.
    • (1992) Eur J Pharmacol , vol.218 , pp. 311-317
    • Nishiyama, A.1    Tamaki, T.2    Masumura, H.3
  • 42
    • 0027281668 scopus 로고
    • Inhibition of rabbit aortic angiotensin II(AII) receptor by CV-11974, a new nonpeptide AII antagonist
    • Noda M, Shibouta Y, Inada Y, et al. Inhibition of rabbit aortic angiotensin II(AII) receptor by CV-11974, a new nonpeptide AII antagonist. Biochem Pharmacol 1993;46:311-318.
    • (1993) Biochem Pharmacol , vol.46 , pp. 311-318
    • Noda, M.1    Shibouta, Y.2    Inada, Y.3
  • 43
    • 0027509397 scopus 로고
    • Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans
    • Ohtawa M, Takayama F, Saitoh K, Yoshinaga T, Nakashima M. Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans. Br J Clin Pharmacol 1993;35:290-297.
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 290-297
    • Ohtawa, M.1    Takayama, F.2    Saitoh, K.3    Yoshinaga, T.4    Nakashima, M.5
  • 44
    • 0027519507 scopus 로고
    • Analysis of the inhibitory effects of DuP753 and EXP3174 on responses to angiotensin II in the feline hindquarters vascular bed
    • Osei S, Minkes R, Bellan J, Kadowitz P. Analysis of the inhibitory effects of DuP753 and EXP3174 on responses to angiotensin II in the feline hindquarters vascular bed. J Pharmacol Exp Ther 1993;264:1104-1112.
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 1104-1112
    • Osei, S.1    Minkes, R.2    Bellan, J.3    Kadowitz, P.4
  • 45
    • 0015165769 scopus 로고
    • A specific competitive antagonist of the vascular action of angiotensin II
    • Pals D, Masucci F, Sipos F, Denning G. A specific competitive antagonist of the vascular action of angiotensin II. Circ Res 1971;29:664-672.
    • (1971) Circ Res , vol.29 , pp. 664-672
    • Pals, D.1    Masucci, F.2    Sipos, F.3    Denning, G.4
  • 46
    • 0027158296 scopus 로고
    • Systemic and coronary effects of the angiotensin II receptor antagonist EXP3174 in dogs
    • Richard V, Berdeaux A, Giudicelli J. Systemic and coronary effects of the angiotensin II receptor antagonist EXP3174 in dogs. J Cardiovasc Pharmacol 1993;22:52-57.
    • (1993) J Cardiovasc Pharmacol , vol.22 , pp. 52-57
    • Richard, V.1    Berdeaux, A.2    Giudicelli, J.3
  • 47
    • 0027141433 scopus 로고
    • Comparison of the effects of EXP3174, an angiotensin II antagonist, and enalaprilat on myocardial infarct size in anesthetized dogs
    • Richard V, Ghaleh B, Berdeax A, Giudicelli J. Comparison of the effects of EXP3174, an angiotensin II antagonist, and enalaprilat on myocardial infarct size in anesthetized dogs. Br J Pharmacol 1993;110:969-974.
    • (1993) Br J Pharmacol , vol.110 , pp. 969-974
    • Richard, V.1    Ghaleh, B.2    Berdeax, A.3    Giudicelli, J.4
  • 48
    • 0027324780 scopus 로고
    • EXP3174, a metabolite of losartan (MK954, DuP753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells
    • Sachinidis A, Ko Y, Weisser P, et al. EXP3174, a metabolite of losartan (MK954, DuP753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells. J Hypertension 1993;11:155-162.
    • (1993) J Hypertension , vol.11 , pp. 155-162
    • Sachinidis, A.1    Ko, Y.2    Weisser, P.3
  • 49
    • 0014025361 scopus 로고
    • Localization of diuretic action from the pattern of water and electrolyte excretion
    • Seldin DW, Eknoyan G, Suki WN, Rector FC. Localization of diuretic action from the pattern of water and electrolyte excretion. Ann NY Acad Sci 1966;139:328-343.
    • (1966) Ann NY Acad Sci , vol.139 , pp. 328-343
    • Seldin, D.W.1    Eknoyan, G.2    Suki, W.N.3    Rector, F.C.4
  • 50
    • 0027431141 scopus 로고
    • Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist,2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl]-1H-benzimidazole- 7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2′-(1H- tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116)
    • Shibouta Y, Inada Y, Ojima M, et al. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole- 7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole- 7-carboxylate (TCV-116). J Pharmacol Exp Ther 1993;266:114-120.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 114-120
    • Shibouta, Y.1    Inada, Y.2    Ojima, M.3
  • 51
    • 0029096977 scopus 로고
    • Pharmacokinetics of losartan in renal insufficiency
    • Sica D, Lo M, Shaw W, et al. Pharmacokinetics of losartan in renal insufficiency. J Hypertens (Suppl 1) 1995;13:549-552.
    • (1995) J Hypertens , vol.13 , Issue.1 SUPPL. , pp. 549-552
    • Sica, D.1    Lo, M.2    Shaw, W.3
  • 52
    • 0028894286 scopus 로고
    • Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members
    • Stearns R, Chakravarty P, Chen R, Chiu S. Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members. Drug Metab Dispos 1995;23:207-215.
    • (1995) Drug Metab Dispos , vol.23 , pp. 207-215
    • Stearns, R.1    Chakravarty, P.2    Chen, R.3    Chiu, S.4
  • 53
    • 0026561612 scopus 로고
    • The metabolism of DuP753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices
    • Stearns R, Miller R, Doss G, et al. The metabolism of DuP753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices. Drug Metab Dispos 1992;20:281-287.
    • (1992) Drug Metab Dispos , vol.20 , pp. 281-287
    • Stearns, R.1    Miller, R.2    Doss, G.3
  • 54
    • 0000104361 scopus 로고
    • Angiotensin-receptor blocking drugs
    • Birkennhager WH, Reid JL, eds. Amsterdam:Elsevier
    • Streeten DHP, Anderson GHJ. Angiotensin-receptor blocking drugs. In: Birkennhager WH, Reid JL, eds. Handbook of Hypertension. Amsterdam:Elsevier, 1984:246-271.
    • (1984) Handbook of Hypertension , pp. 246-271
    • Streeten, D.H.P.1    Anderson, G.H.J.2
  • 55
    • 0010439460 scopus 로고
    • The site of action of furosemide and other sulfonamide diuretics in the dog
    • Suki W, Rector FC, Seldin DW. The site of action of furosemide and other sulfonamide diuretics in the dog. J Clin Invest 1965;44:1458-1469.
    • (1965) J Clin Invest , vol.44 , pp. 1458-1469
    • Suki, W.1    Rector, F.C.2    Seldin, D.W.3
  • 56
    • 0028593665 scopus 로고
    • Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension
    • Sweet C, Bradstreet D, Berman R, Jallard N, Saenz A, Weidler D. Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. Am J Hypertens 1994;7:1035-1040.
    • (1994) Am J Hypertens , vol.7 , pp. 1035-1040
    • Sweet, C.1    Bradstreet, D.2    Berman, R.3    Jallard, N.4    Saenz, A.5    Weidler, D.6
  • 57
    • 0027245459 scopus 로고
    • Effects of EXP3174, a non-peptide angiotensin II receptor antagonist, on renal hemodynamics and renal function in dogs
    • Tamaki T, Nishiyama A, Yoshida H, et al. Effects of EXP3174, a non-peptide angiotensin II receptor antagonist, on renal hemodynamics and renal function in dogs. Eur J Pharmacol 1993;236:15-21.
    • (1993) Eur J Pharmacol , vol.236 , pp. 15-21
    • Tamaki, T.1    Nishiyama, A.2    Yoshida, H.3
  • 58
    • 0026004798 scopus 로고
    • Angiotensin II receptor antagonists. from discovery to antihypertensive drugs
    • Timmermans P, Carini D, Chiu A, et al. Angiotensin II receptor antagonists. From discovery to antihypertensive drugs. Hypertension (Suppl III) 1991;18:136-142.
    • (1991) Hypertension , vol.18 , Issue.3 SUPPL. , pp. 136-142
    • Timmermans, P.1    Carini, D.2    Chiu, A.3
  • 59
    • 0027208070 scopus 로고
    • Angiotensin II receptors and angiotensin II receptor antagonists
    • Timmermans PBMWM, Wong PC, Chiu AT, et al. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993;45:205-251.
    • (1993) Pharmacol Rev , vol.45 , pp. 205-251
    • Timmermans, P.B.M.W.M.1    Wong, P.C.2    Chiu, A.T.3
  • 60
    • 0027398576 scopus 로고
    • Hypotensive effect of losartan, a nonpeptide angiotensin II receptor antagonist, in essential hypertension
    • Tsunoda L, Abe K, Hagino T, et al. Hypotensive effect of losartan, a nonpeptide angiotensin II receptor antagonist, in essential hypertension. Am J Hypertens 1993;6:28-32.
    • (1993) Am J Hypertens , vol.6 , pp. 28-32
    • Tsunoda, L.1    Abe, K.2    Hagino, T.3
  • 61
    • 0027077499 scopus 로고
    • Clinical experience with the angiotensin II receptor antagonist losartan: A preliminary report
    • Weber M. Clinical experience with the angiotensin II receptor antagonist losartan: A preliminary report. Am J Hypertens 1992;5:247S-251S
    • (1992) Am J Hypertens , vol.5
    • Weber, M.1
  • 62
    • 0027512175 scopus 로고
    • 1-receptor antagonists, losartan and EXP3174, in water-derived Brattleboro rats
    • 1-receptor antagonists, losartan and EXP3174, in water-derived Brattleboro rats. Br J Pharmacol 1993; 108:684-688.
    • (1993) Br J Pharmacol , vol.108 , pp. 684-688
    • Widdop, R.1    Gardiner, S.2    Kemp, P.3    Bennett, T.4
  • 63
    • 0025823899 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists. Studies with Dup 753 and EXP3174 in dogs
    • Wong PC, Hart SD, Duncia JV, Timmermans PBWM. Nonpeptide angiotensin II receptor antagonists. Studies with Dup 753 and EXP3174 in dogs. Eur J Pharmacol 1991;202:323-330.
    • (1991) Eur J Pharmacol , vol.202 , pp. 323-330
    • Wong, P.C.1    Hart, S.D.2    Duncia, J.V.3    Timmermans, P.B.W.M.4
  • 64
    • 0025305206 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP753, an orally active antihypertensive agent
    • Wong PC, Price WA, Chiu AT, et al. Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP753, an orally active antihypertensive agent. J Pharmacol Exp Ther 1990;252:726-732.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 726-732
    • Wong, P.C.1    Price, W.A.2    Chiu, A.T.3
  • 65
    • 0025275076 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent
    • Wong PC, Price WA, Chiu AT, et al. Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent. J Pharmacol Exp Ther 1990;252:719-725.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 719-725
    • Wong, P.C.1    Price, W.A.2    Chiu, A.T.3
  • 66
    • 0025217443 scopus 로고
    • Hypotensive action of Dup 753, an angiotensin II antagonist, in spontaneously hypertensive rats
    • Wong PC, Price WA, Chiu AT, et al. Hypotensive action of Dup 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Hypertension 1990;15:459-468.
    • (1990) Hypertension , vol.15 , pp. 459-468
    • Wong, P.C.1    Price, W.A.2    Chiu, A.T.3
  • 67
    • 0025086862 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: An active metabolite of Dup 753, an orally active antihypertensive agent
    • Wong PC, Price WA, Chiu AT, et al. Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: An active metabolite of Dup 753, an orally active antihypertensive agent. J Pharmacol Exp Ther 1990;255:211-217.
    • (1990) J Pharmacol Exp Ther , vol.255 , pp. 211-217
    • Wong, P.C.1    Price, W.A.2    Chiu, A.T.3
  • 68
    • 0025370619 scopus 로고
    • Nonpeptide angiotensin II receptor antagonists, studies with EXP9270 and DuP753
    • Wong PC, Price WA, Chui AT, et al. Nonpeptide angiotensin II receptor antagonists, studies with EXP9270 and DuP753. Hypertension 1990;15:823-834.
    • (1990) Hypertension , vol.15 , pp. 823-834
    • Wong, P.C.1    Price, W.A.2    Chui, A.T.3
  • 69
    • 0028896177 scopus 로고
    • Oxidation of the angiotensin II receptor antagonist losartan (DuP753) in human liver microsomes. Role of cytochrome P4503A(4) in formation of the active metabolite EXP3174
    • Yun C, Lee H, Lee H, Rho J, Jeong H, Guengerich F. Oxidation of the angiotensin II receptor antagonist losartan (DuP753) in human liver microsomes. Role of cytochrome P4503A(4) in formation of the active metabolite EXP3174. Drug Metab Dispos 1995;23:285-289.
    • (1995) Drug Metab Dispos , vol.23 , pp. 285-289
    • Yun, C.1    Lee, H.2    Lee, H.3    Rho, J.4    Jeong, H.5    Guengerich, F.6
  • 70
    • 0021205614 scopus 로고
    • Renin- and non-renin-mediated antihypertensive actions of converting enzyme inhibitors
    • Zusman RM. Renin- and non-renin-mediated antihypertensive actions of converting enzyme inhibitors. Kidney Int 1984;25:969-983.
    • (1984) Kidney Int , vol.25 , pp. 969-983
    • Zusman, R.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.