Interaction of nonpeptide angiotensin II receptor antagonists with the urate transporter in rat renal brush-border membranes

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 1, 1996, Pages 125-129

  Edwards, Richard M ^a   Trizna, Walt ^a   Stack, Elwood J ^a   Weinstock, Joseph ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; EPROSARTAN; LOSARTAN; SB 203220; UNCLASSIFIED DRUG; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANION EXCHANGE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; HYPERTENSION; HYPERURICOSURIA; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EPITHELIUM; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; URIC ACID URINE LEVEL;

ACRYLATES; ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL TRANSPORT; BIPHENYL COMPOUNDS; CARBON RADIOISOTOPES; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; KIDNEY; KINETICS; LOSARTAN; MALE; MICROVILLI; NAPHTHALENES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANGIOTENSIN; TETRAZOLES; THIOPHENES; URIC ACID;

EID: 0029925086     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. BAKER, E., VICKERY-CLARK, L., OHLSTEIN, E. H., WEINSTOCK, J., EDWARDS, R. AND AIYAR, N.: Pharmacology of a potent long-acting imidazole-5-acrylic acid angiotensin II AT-1 receptor antagonist. FASEB J. 8: A832, 1994
2. BLOMSTEDT, J. W. AND ARONSON, P. S.: pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles. J. Clin Invest. 65: 931-934, 1980.
3. BOIKE, S., ILSON, E., AUDET, P., FREED, M., EVERITT, D., BROWN, L. AND JORKASKY, D.: The angiotensin II receptor antagonist SK&F 108566 does not increase uric acid (UA) excretion in healthy men. J. Am. Soc. Neph 4: 530, 1993.
4. BOUMENDIL-PODEVIN, E. F., PODEVIN, R. A AND PRIOL, C : Uric acid transport in brush border membrane vesicles isolated from rabbit kidney. Am. J. Physiol. 236: F519-F525, 1979.
5. CHIU, A. T., MCCALL, D. E., PRICE, W. A., WONG, P. C., CARINI, D. J., DUNCIA, J. V., JOHNSON, A. L., WEXLER, R. R., YOO, S. E. AND TIMMERMANS, P. B. M. W. M.: Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent. J. Pharmacol Exp. Ther. 252: 711-718, 1990.
6. CHRISTEN, Y., WAEBER, B., NUSSBERGER, J., PORCHET, M., BORLAND, R. M., LEE, R. J., MAGGON, K., SHUM, L., TIMMERMANS, P. B. M. W. M. AND BRUNNER, H. R.: Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers: Inhibition of pressor response to exogenous angiotensin I and II Circulation 83: 1333-1342, 1991.
7. DAN, T. AND KOGA, H.: Uricosurics inhibit urate transporter in rat renal brush border membrane vesicles. Eur. J. Pharmacol. 187: 303-312, 1990.
8. DIAMOND, H. S.: Uricosuric drugs. In Handbook of Experimental Pharmacology, vol. 51, Uric Acid, ed. by W. N. Kelley and I. M. Weiner, p. 459, Springer-Verlag, New York, 1978.
9. EDWARDS, R. M., AIYAR, N., OHLSTEIN, E. H., WEIDLEY, E. F., GRIFFIN, E., EZEKIEL, M , KEENAN, R. M., RUFFOLO, R. R. JR. AND WEINSTOCK, J.: Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J. Pharmacol. Exp. Ther. 260: 175-181, 1992.
10. ILSON, B., BOIKE, S., AUDET, P., FREED, M., EVERITT, D., BROWN, L., ZARIFFA, N. AND JORKASKY, D.: Renal hemodynamic effects of SK&F 108566, a nonpeptide selective angiotensin (AII) receptor AT1 antagonist. J. Am. Soc. Neph. 4: 580, 1993.
11. ILSON, B., BOIKE, S., LAROUCHE, J., FREED, M. AND JORKASKY, D.: The angiotensin II receptor antagonist SB 203220 does not increase uric acid (UA) excretion in healthy men. J. Am. Soc Neph. 5: 562, 1994.
12. KAHN, A. M. AND ARONSON, P. S.: Urate transport via anion exchange in dog renal microvillus membrane vesicles. Am. J. Physiol. 244: F56-F63, 1983.
13. KAHN, A. M. AND WEINMAN, E. J.: Urate transport in the proximal tubule. In vivo and vesicle studies. Am. J. Physiol. 249: F789-F798, 1985.
14. KAHN, A. M., BRANHAM, S. AND WEINMAN, E. J.. Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles. Am. J. Physiol. 245: F151-F158, 1983.
15. LOWRY, O. H., ROSENBROUGH, N. J., FARR, A. L. AND RANDALL, R. J.. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
16. MOLLER, J. V. AND SHEIKH, I.: Renal organic anion transport system: Pharmacological, physiological and biochemical aspects. Pharmacol. Rev. 34: 315-358, 1983.
17. MUNAFO, A., CHRISTEN, Y., NUSSBERGER, J., SHUM, L. Y., BORLAND, R. M., LEE, R. J., WAEBER, B., BIOLLAZ, J. AND BRUNNER, H. R.: Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist. Clin. Pharmacol. Ther 51: 513-521, 1992.
18. NAKASHIMA, M., UEMATSU, T., KOSUGE, K. AND KANAMURA, M.: Pilot study of the uricosuric effect of DuP 753, a new angiotensin II receptor antagonist, in healthy subjects. Eur. J. Clin Pharmacol. 42: 333-335, 1992.
19. ROCH-RAMEL, F., WERNER, D. AND GUISAN, B.: Urate transport in brush-border membrane of human kidney. Am. J. Physiol. 266: F797-F805, 1994.
20. SHAH, S. V., KEMPSON, S. A., NOHTHRUP, T. E. AND DOUSA, T. P.: Renal adaptation to a low phosphate diet in rats. Blockade by actinomycin D. J. Clin. Invest. 64: 955-966, 1979.
21. SWEET, C. S., BRADSTREET, D. C., BERMAN, R. S., JALLARD, N., SAENZ, A. AND WEIDLER, D. J.: Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension. Am. J. Hypertens. 7: 1035-1040, 1994.
22. TSUNODA, K., ABE, K., HAGINO, T., OMATA, K., MISAWA, S., IMAI, Y AND YOSHINAGA, K.: Hypotensive effect of losartan, a nonpeptide angiotensin II receptor antagonist, in essential hypertension. Am. J. Hypertens 6: 28-32, 1993.
23. ULLRICH, K. J. AND RUMRICH, G.: Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions. Am. J. Physiol. 254: F453-F462, 1988.
24. WERNER, D., MARTINEZ, F. AND ROCH-RAMEL, F.: Urate and p-aminohippurate transport in the brush border membrane of the pig kidney. J. Pharmacol Exp. Ther. 252: 792-799, 1990.
25. WONG, P. C., PRICE, W. A., CHIU, A. T., DUNCIA, J. V., CARINI, D. J., JOHNSON, A. L., WEXLER, R. R. AND TIMMERMANS, P. B. M. W. M.: Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP 3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J. Pharmacol. Exp. Ther. 255: 211-217, 1990.