The genotoxicity of diaveridine and trimethoprim

Environmental Toxicology and Pharmacology

Volumn 3, Issue 4, 1997, Pages 297-306

  Ono, Tomoko ^a   Sekiya, Tatsuro ^a   Takahashi, Yoshiyuki ^a   Sasaki, Yu F ^b   Izumiyama, Fusako ^b   Nishidate, Emi ^b   Tsuda, Shuji ^c   Ohta, Toshihiro ^d  

^a National Veterinary Assay Laboratory   (Japan)

^b HACHINOHE NATIONAL COLLEGE OF TECHNOLOGY   (Japan)

^c IWATE UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Clastogen; Comet assay; Diaveridine; Micronucleus test; Trimethoprim

Indexed keywords

DIAVERIDINE; TRIMETHOPRIM;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; ESCHERICHIA COLI; GENOTOXICITY; METABOLIC ACTIVATION; MICRONUCLEUS TEST; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SALMONELLA TYPHIMURIUM; STRUCTURAL CHROMOSOME ABERRATION;

EID: 0030863896     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(97)00026-4     Document Type: Article

References (24)

1. Antoccia, A., Degrassi, F., Battistoni, A., Ciliutti, P., Tanzarella, C., 1991. In vitro micronucleus test with kinetochore staining: evaluation of test performance. Mutagenesis 6, 319-324.
2. Egeli, U., Erdogan, G., 1991. The clastogenic effects of pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures. Cell Biol. Toxicol. 7, 347-356.
3. Fairbairn, D.W., Olive, P.L., O'Neill, K.L., 1995. The comet assay: a comprehensive review. Mutat. Res. 339, 37-59.
4. Gatehouse, D., Haworth, S., Cebula, T., Gocke, E., Kier, L., Matsushima, T., Melcion, C., Nohmi, T., Ohta, T., Venitt, S., Zeiger, E., 1994. Recommendations for the performance of bacterial mutation assays. Mutat. Res. 312, 217-233.
5. Hayashi, M., Sofuni, T., Ishidate, M. Jr., 1983. An application of acridine orange fluorescent staining to the micronucleus test. Mutat. Res. 120, 241-247.
6. Kastenbaum, M.A., Bowman, K.O., 1970. Tables for determining the statistical significance of mutation frequencies. Mutat. Res. 9, 527-549.
7. Kato, T., Watanabe, M., Ohta, T., 1994. Induction of the SOS response and mutations by reactive oxygen-generating compounds in various Escherichia coli mutants defective in the mutM, mutY or soxRS loci. Mutagenesis 9, 245-251.
8. Kirkland, D., 1994. Report of the in vitro sub-group: International workshop on standardization of genotoxicity test procedures. Mutat. Res. 312, 211-215.
9. Koyama, H., Utakoji, T., Ono, T., 1970. A new cell line derived from newborn Chinese hamster lung tissue. Gann 61, 161-167.
10. Lee, J.-G., Madden, M.C., Reed, W., Adler, K., Devlin, R., 1996. The use of the single cell gel electrophoresis assay in detecting DNA single strand breaks in lung cells in vitro. Toxicol. Appl. Pharmacol. 141, 195-204.
11. Maron, D.M., Ames, B.N., 1983. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 94, 315-330.
12. Miller, J.H., 1972. Experiments in Molecular Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 352-355.
13. Oda, Y., Nakamura, S., Oki, I., Kato, T., Shinagawa, H., 1985. Evaluation of new system (umu-test) for the detection of environmental mutagens and carcinogens. Mutat. Res. 147, 219-229.
14. Ohta, T., Moriya, M., Kaneda, Y., Watanabe, K., Miyazawa, T., Sugiyama, F., Shirasu, Y., 1980. Mutagenicity screening of feed additives in the microbial system. Mutat. Res. 77, 21-30.
15. Ono, T., Norimatsu, M., Yoshimura, H., 1994. Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells. Mutat. Res. 323, 197-201.
16. Ono, T., Yoshimura, H., 1996. Analysis of micronucleus induction of pyrimethamine in in vitro CHL cells and in in vivo mouse bone marrow cells. Mutagenesis 11, 85-88.
17. Ono, T., Sekiya, T., Takahashi, Y., Sasaki, Y.F., Ohta, T., 1997. Species-specificity of pyrimethamine in the rodent bone marrow micronucleus test. Mutat. Res. 390, 167-170.
18. Sasaki, Y.F., Tsuda, S., Izumiyama, F., Nishidate, E., 1997. Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay. Mutat. Res. 388, 33-44.
19. Sasaki, Y.F., Izumiyama, F., Nishidate, E., Ohta, T., Ono, T., Matsusaka, N., Tsuda, S., in press, a. Simple detection of in vivo genotoxicity of pyrimethamine in rodents by the modified alkaline single cell gel electrophoresis assay, Mutat. Res.
20. Sasaki, Y.F., Izumiyama, F., Nishidate, E., Matsusaka, N., Tsuda, S., in press, b. Detection of rodent liver carcinogen genotoxicity by the alkaline single cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow), Mutat. Res.
21. Schmid, W., 1976. The micronucleus test for cytogenetic analysis. In: Hollaender, A. (Eds.), Chemical Mutagens, vol. 4. Plenum Press, New York, pp. 31-53.
22. Singh, N.P., McCoy, M.T., Tice, R.R., Schneider, E.L., 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191.
23. Singh, N.P., Tice, R.R., Stephens, R.E., Schneider, E.L., 1991. A microgel electrophoresis technique for the direct quantitation of DNA damage and repair in individual fibroblasts cultured on microscope slides. Mutat. Res. 252, 289-296.
24. Yoshimura, H., 1991. Mutagenicity of the coccidiostat diaveridine in the Salmonella/mammalian microsome assay. Mutat. Res. 261, 149-152.