Competitive NMDA and strychnine-insensitive glycine-site antagonists disrupt prepulse inhibition

Pharmacology Biochemistry and Behavior

Volumn 57, Issue 4, 1997, Pages 909-913

  Furuya, Yoshiaki ^a   Ogura, Hiroo ^a  

^a EISAI CO LTD   (Japan)

Author keywords

5,7 Dichlorokyn urenate; CGS 19755; NMDA receptor; Phencyclidine; Prepulse inhibition; Rat; Spontaneous locomotor activity; Strychnine insensitive glycine receptor

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; 5,7 DICHLOROKYNURENIC ACID; GLYCINE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; STRYCHNINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; NEUROTRANSMISSION; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ACOUSTIC STIMULATION; ANIMALS; BINDING, COMPETITIVE; DEPRESSION, CHEMICAL; EXCITATORY AMINO ACID ANTAGONISTS; KYNURENIC ACID; MALE; MOTOR ACTIVITY; PHENCYCLIDINE; PIPECOLIC ACIDS; RATS; RATS, WISTAR; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; STARTLE REACTION; SYNAPTIC TRANSMISSION;

ANIMALIA; STRYCHNOS TOXIFERA;

EID: 0030862847     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00452-2     Document Type: Article

References (34)

1. Baron, S. P.; Woods, J. H.: Competitive and uncompetitive N-methyl-D-aspartate antagonist discrimination in pigeons: CGS 19755 and phencyclidine. Psychopharmacology 118:42-51; 1995.
2. Bennett, D. A.; Bernard, P. S.; Amrick, C. L.; Wilson, D. E.; Liebman, J. M.; Hutchison, A. J.: Behavioral pharmacological profile of CGS 19755, a competitive antagonist at the N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther. 250:454-460; 1989.
3. Braff, D. L.; Geyer, M. A.: Sensorimotor gating and schizophrenia: Human and animal model studies. Arch. Gen. Psychiatry 47: 181-188; 1990.
4. Braff, D. L.; Grillon, C.; Geyer, M. A.: Gating and habituation of the startle reflex in schizophrenic patients. Arch. Gen. Psychiatry 49:206-215; 1992.
5. Carlsson, M.; Carlsson, A.: Interaction between glutamatergic and monoaminergic systems within the basal ganglia - Implications for schizophrenia and Parkinson's disease. Trends Neurosci. 13:272-276; 1990.
6. Castellanos, F. X.; Fine, E. J.; Kaysen, D.; Marsh, W. L.; Rapoport, J. L.; Hallett, M.: Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results. Biol. Psychiatry 39:33-41; 1996.
7. De Sarro, G. B.; De Sarro, A.: Anticonvulsant properties of non-competitive antagonists of the N-methyl-D-aspartate receptor in genetically epilepsy-prone rats: Comparison with CPPene. Neuropharmacology 32:51-58; 1993.
8. Geyer, M. A.; Swerdlow, N. R.; Mansbach, R. S.; Braff, D. L.: Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res. Bull. 25:485-498; 1990.
9. Grillon, C.; Ameli, R.; Charney, D. S.; Krystal, J.; Braff, D. L.: Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biol. Psychiatry 32:939-943; 1992.
10. Hashimoto, A.; Nishikawa, T.; Oka, T.; Takahashi, K.: Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging. J. Neurochem. 60:783-786; 1993.
11. Ishimaru, M.; Kurumaji, A.; Toru, M.: Increase in strychnine-insensitive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis. Biol. Psychiatry 35:84-95; 1994.
12. Javitt, D. C.: Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia. Hillside J. Clin. Psychiatry 9:12-35; 1980.
13. Johansson, C.; Jackson, D. M.; Zhang, J.; Svensson, L.: Prepulse inhibition of acoustic startle, a measure of sensorimotor gating: Effects of antipsychotics and other agents in rats. Pharmacol. Biochem. Behav. 52:649-654; 1995.
14. Johnson, K. M.: Phencyclidine: Behavioral and biochemical evidence supporting a role for dopamine. Fed. Proc. 42:2579-2583; 1983.
15. Kornhuber, J. C.; Kornhuber, M. E.: Presynaptic dopaminergic modulation of cortical input to the striatum. Life Sci. 39:669-674; 1986.
16. 3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients. J. Neural Transm. 77:231-236; 1989.
17. Leander, J. D.; Rathbun, R. C.; Zimmerman, D. M.: Anticonvulsant effects of phencyclidine-like drugs: Relation to N-methyl-D-aspartic acid antagonism. Brain Res. 454:368-372; 1988.
18. Mansbach, R. S.: Effect of NMDA receptor ligands on sensorimotor gating in the rat. Eur. J. Pharmacol. 202:61-66; 1991.
19. Mansbach, R. S.; Geyer, M. A.: Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuro-psychopharmacology 2:299-308; 1989.
20. Mansbach, R. S.; Geyer, M. A.; Braff, D. L.: Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94:507-514; 1988.
21. Olverman, H. J.; Watkins, J. C.: NMDA agonists and competitive antagonists. In: Watkins, J. C.; Collingridge, G. L., eds. The NMDA receptor. Oxford, UK: Oxford University Press; 1989:19-36.
22. Ornitz, E. M.; Hanna, G. L.; de Traversay, J.: Prestimulation-induced startle modulation in attention-deficit hyperactivity disorder and nocturnal enuresis. Psychophysiology 29:437-451; 1992.
23. Paxinos, G.; Watson, C.: The rat brain in stereotaxic coordinates, 2nd ed. New York: Academic Press; 1986.
24. Peng, R. Y.; Mansbach, R. S.; Braff, D. L.; Geyer, M. A.: A D2 dopamine receptor agonist disrupts sensorimotor gating in rats: Implication for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology 3:211-218; 1990.
25. 1A receptor agonists block prepulse inhibition of the acoustic startle reflex. J. Pharmacol. Exp. Ther. 263:486-493; 1992.
26. Rogawski, M. A.: The NMDA receptor, NMDA antagonists and epilepsy therapy. Drugs 44:279-292; 1992.
27. Sherman, A. D.; Davidson, A. T.; Barnah, C.; Hegwood, T. S.; Waziri, R.: Evidence of glutamatergic deficiency in schizophrenia. Neurosci. Lett. 121:77-80; 1991.
28. Sherman, A. D.; Hegwood, T. S.; Baruah, C.; Waziri, R.: Deficient NMDA-mediated glutamate release from synaptosomes of schizophrenics. Biol. Psychiatry 30:1191-1198; 1991.
29. Sipes, T. A.; Geyer, M. A.: Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats. Neuropharmacology 33:441-448; 1994.
30. Sipes, T. A.; Geyer, M. A.: 8-OH-DPAT disruption of prepulse inhibition in rats: Reversal with (+)WAY 100,135 and localization of site of action. Psychopharmacology 117:41-48; 1995.
31. Swerdlow, N. R.; Benbow, C. H.; Zisook, S.; Geyer, M. A.; Braff, D. L.: A preliminary assessment of sensorimotor gating in patients with obsessive-compulsive disorder (OCD). Biol. Psychiatry 33:298-301; 1993.
32. Swerdlow, N. R.; Caine, B. C.; Braff, D. L.; Geyer, M. A.: Neural substrates of sensorimotor gating of the startle reflex: A review of recent findings and their implications. J. Psychopharmacol. 6:176-190; 1992.
33. Swerdlow, N. R.; Paulsen, J.; Braff, D. L.; Butters, N.; Geyer, M. A.; Swenson, M. R.: Impaired prepulse inhibition of acoustic and tactile response in patients with Huntington's disease. J. Neurol. Neurosurg. Psychiatry 58:192-200; 1995.
34. Wood, P. L.: The co-agonist concept: Is the NMDA-associated glycine receptor saturated in vivo? Life Sci. 57:301-310; 1995.