Absence of short-term effects of glucagon-like peptide-1 and of hyperglycemia on plasma leptin levels in man

Metabolism: Clinical and Experimental

Volumn 46, Issue 7, 1997, Pages 723-725

  Shalev, Anath ^a   Vosmeer, Susanne ^a   Keller, Ulrich ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GLUCAGON LIKE PEPTIDE 1; LEPTIN; NEUROPEPTIDE Y;

ADULT; ARTICLE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG RECEPTOR BINDING; ENERGY EXPENDITURE; GENE EXPRESSION REGULATION; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STIMULUS RESPONSE;

EID: 0030859202     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90112-8     Document Type: Article

References (17)

1. Halaas JL, Gajiwala KS, Maifei M, et al: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
2. Schwartz MW, Baskin DG, Bukowski TR, et al: Specificity of leptin action on blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-536, 1996
3. Orskov C, Holst JJ, Knuhtsen S, et al: Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas. Endocrinology 119:1467-1475, 1986
4. Scrocchi LA, Brown TJ, MacLusky N, et al: Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 2:1254-1258, 1996
5. Turton MD, O'Shea D, Gunn I, et al: A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379:69-72, 1996
6. Navarro M, Rodriguez de Fonseca F, Alvarez E, et al: Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: Evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J Neurochem 67:1982-1991, 1996
7. Tartaglia LA, Dembski M, Weng X, et al: Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271, 1995
8. Bullock BP, Heller RS, Habener JF: Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 137:2968-2978, 1996
9. Wei Y, Mojsov S: Tissue-specific expression of the human receptor for glucagon-like peptide-1: Brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett 358:219-224, 1995
10. Mizuno TM, Bergen H, Funabashi T, et al: Obese gene expression: Reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity. Proc Natl Acad Sci USA 93:3434-3438, 1996
11. Kolaczynski JW, Nyce MR, Considine RV, et al: Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes 45:699-701, 1996
12. Valverde I, Merida E, Delgado E, et al: Presence and characterization of glucagon-like peptide-1 (7-36) amide receptors in solubilized membranes of rat adipose tissue. Endocrinology 132:75-79, 1993
13. Oben J, Morgan L, Fletcher J, et al: Effects of the enteropancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1 (7-36) amide, on fatty acid synthesis in explants of rat adipose tissues. J Endocrinol 130:267-272, 1991
14. Ruiz-Grande C, Alarcon C, Merida E, et al: Lipolytic action of glucagon-like peptides in isolated rat adipocytes. Peptides 13:13-16, 1992
15. Shalev A, Hoist JJ, Keller U: Effects of glucagon-like peptide 1 (7-36) amide) on whole body protein metabolism in man. Eur J Clin Invest 27:10-16, 1997
16. Nauck MA, Heimesaat MM, Orskov C, et al: Preserved incretin activity of glucagon-like peptide 1 (7-36 amide) but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91:301-307, 1993
17. Orskov C, Rabenhoj L, Wettergren A, et al: Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptidel in humans. Diabetes 43:535-539, 1994