Effects of inhibitors of signal transduction pathways on transforming growth factor β1 and osteogenic protein-1-induced insulinlike growth factor binding protein-3 expression in human bone cells

Journal of Cellular Physiology

Volumn 173, Issue 1, 1997, Pages 28-35

  Srinivasan, Narasimhan ^a,b   Baylink, David J ^a,b   Sampath, Kuber ^c   Mohan, Subburaman ^a,b,d  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Jerry L Pettis Memorial VA Medical Center   (United States)

^c CURIS INC   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; GENISTEIN; OKADAIC ACID; OSTEOGENIC PROTEIN 1; PROTEIN KINASE C INHIBITOR; SOMATOMEDIN BINDING PROTEIN 3; STAUROSPORINE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BONE CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BONE AND BONES; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; GENE EXPRESSION REGULATION; GENISTEIN; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; ISOFLAVONES; OKADAIC ACID; OSTEOBLASTS; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAUROSPORINE; TETRADECANOYLPHORBOL ACETATE; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; VANADATES;

EID: 0030858145     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199710)173:1<28::AID-JCP4>3.0.CO;2-L     Document Type: Article

References (31)

1. Atfi, A., Drobetsky, E., Boissonneault, M., Chapdelaine, A., and Chevalier, S. (1994) Transforming growth factor beta down-regulates Src family protein tyrosine kinase signaling pathways. J. Biol. Chem., 269:13600-13603.
2. Bagi, C., van der Meulen, M., Brommage, R., Rosen, D., and Sommer A. (1995) The effect of systemically administered rhIGF-I/IGFBP-3 complex on cortical bone strength and structure in ovariectomized rats. Bone, 16:559-565.
3. Bagi, C.M., Brommage, R., Deleon, L., Adams, S., Rosen, D., and Sommer, A. (1994) Benefit of systemically administered rhIGF-I and rhIGF-I/IGFBP-3 on cancellous bone in ovariectomized rats. J. Bone Min. Res., 9:1301-1312.
4. Baylink, D.J., Finkelman, R.D., and Mohan, S. (1993) Growth factors to stimulate bone formation [review]. J. Bone Min. Res., Suppl. 2, 8:S565-S572.
5. Bonewald, L.F., and Dallas, S.L. (1994) Role of active and latent transforming growth factor β in bone formation. J. Cell Biochem., 55:350-357
6. Centrella, M., Horowitz, M.C., Wozney, J.M., and McCarthy, T.L. (1994) Transforming growth factor β gene family members in bone. Endocr. Rev., 15:27-39.
7. Chomczynski, P., and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal. Biochem., 162:156-159.
8. Dijke, P., Miyazano, K., and Heldin, C.H. (1996) Signaling via heterooligomeric complexes of type I and type II serine/threonine kinase receptors. Curr. Opin. Cell Biol., 8:139-145.
9. Ernst, M., and Rodan, G.A. (1990) Increased activity of insulin-like growth factor (IGF) in osteoblastic cells in the presence of growth hormone (GH): Positive corrrelation with the presence of GH-induced IGF binding protein BP-3. Endocrinology, 127:807-814.
10. Gucev, Z.S., Oh, Y., Kelley, K.M., and Rosenfeld, R.G. (1996) Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor β2-induced growth inhibition in human breast cancer cells. Cancer Res., 56:1545-1550.
11. Halstead, J., Kemp, K., and Ignotz, R.A. (1995) Evidence for involvement of phosphatidylcholine phospholipase C and protein kinase C in transforming growth factor β signaling. J. Biol. Chem., 270:13600-13603.
12. Hoodless, P.A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor M.B., Attisano, L., and Wrana, J.L. (1996) MADR1, a MAD-related protein that functions in BMP-2 signaling pathways. Cell, 85:489-500.
13. Kanzaki, S., Hilliker, S., Baylink, D.J., and Mohan, S. (1994) Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases. Endocrinology, 134:383-392.
14. Knutsen, R., Wergedal, J.E., Sampath, T.K., Baylink, D.J., and Mohan, S. (1993) Osteogenic protein-1 stimulates proliferation and differentiation of human bone cells in vitro. Biochem. Biophys. Res. Commun., 194:1352-1358.
15. Knutsen, R., Honda, Y., Strong, D.D., Sampath, T.K., Baylink, D.J., and Mohan, S. (1995) Regulation of insulin-like growth factor system components by osteogenic protein-1 in human bone cells. Endocrinology, 136:857-865.
16. LaTour, D., Mohan, S., Linkhart, T.A., Baylink, D.J., and Strong, D.D. (1990) Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. Mol. Endocrinol., 4:1806-1814.
17. Lechleider, R.J., Caestecker, M.P., Dehejia, A., Polymeropoulos, M.H., and Roberts, A.B. (1996) Serine phosphorylation, chromosomal localization and transforming growth factor β signal transduction by human bsp-1. J. Biol. Chem., 271:17617-17620.
18. Martin, J.L. and Baxter, R.C. (1991) Transforming growth factor-beta stimulates production of insulin-like growth factor-binding protein-3 by human skin fibroblasts. Endocrinology, 128:1425-1433.
19. Massague, J. (1996) TGFβ signaling: Receptors, transducers, and mad proteins. Cell, 85:947-950.
20. Nakao, Y., Hilliker, S., Baylink, D.J., and Mohan, S. (1994) Studies on the regulation of insulin-like growth factor binding protein 3 secretion in human osteosarcoma cells in vitro. J. Bone Min. Res., 9:865-872.
21. Reddi, A.H. (1994) Bone mophogenetic proteins, bone marrow stromal cells, and mesenchymal stem cells. Clin. Orth. Rel. Res., 313:115-119
22. Sampath, T.K., Maliakal, J.C., Hauschka, P.V., Jones, W.K., Sasak, H., Tucker, R.C., White, K.H., Coughlin, J.E., Tucker, M.M., Pang, R.H.L., Cobett, C., Ozakaynak, E., Oppermann, H., and Rueger, D.C. (1992) Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation in vitro. J. Biol. Chem., 267:20352-20362.
23. Sekelsky, J.J., Newfeld, S.J., Raftery, L.A., Chartoff, E.H., and Gelbart W M. (1995) Genetic characterization and cloning of mothers against dpp, a gene for decapentaplegic function in Drosophila melanogaster. Genetics, 139:1347-1358.
24. Shibuya, H., Yamaguchi, K., Shirakabe, K., Tonegawa, A., Gotoh, Y., Ueno, N., Irie, K., Nishida, E., and Matsumoto, K. (1996) TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction. Science, 272:1179-1182.
25. Weis-Garcia, F., and Massague, J. (1996) Complementation between kinase-defective and activation-defective TGF-β receptors cooperativity for signaling. EMBO J., 15:276-289.
26. Weiser, R., Wrana, J.L., and Massague, J. (1995) GS domain mutations that constitutively activate T beta R-1, the downstream signaling component in the TGF-β receptor complex. EMBO J., 14:2199-2208.
27. Wergedal, J.E., Mohan, S., Lundy, M., and Baylink, D.J. (1990) Skeletal growth factor and other growth factors known to be present in bone matrix stimulate proliferation and protein synthesis in human bone cells. J. Bone Min. Res., 5:179-186.
28. Wozney, J.M. (1992) The bone morphogenetic protein family and osteogenesis. Mol. Rep. Dev., 32:160-167.
29. Yamaguchi, A., Ishizuya, T., Kintou, N., Wada, Y., Katagiri, T., Wozney, J.M., Rosen, V., and Yoshiki, S. (1996) Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem. Biophys. Res. Commun., 220:366-371.
30. Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E., and Matsumoto, K. (1995) Identification of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science, 270:2008-2011.
31. Yan, Z., Winawer, S., and Friedman, E. (1996) Two different signal transduction pathways can be activated by transforming growth factor β1 in epithelial cells. J. Biol. Chem., 269:13231-13237.