Th-1/Th-2 switch regulation in immune responses to inhaled antigens: Role of dendritic cells in the aetiology of allergic respiratory disease

Advances in Experimental Medicine and Biology

Volumn 417, Issue , 1997, Pages 301-306

  Holt, P G ^a   Macaubas, C ^a   Cooper, D ^a   Nelson, D J ^a   McWilliam, A S ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ALLERGY; ANTIGEN BINDING; ANTIGEN PRESENTING CELL; BRONCHUS HYPERREACTIVITY; CELLULAR IMMUNITY; CONFERENCE PAPER; HUMAN; HUMAN CELL; INHALATION; MEMORY CELL; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SEROEPIDEMIOLOGY;

BRONCHUS;

EID: 0030850487     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9966-8_49     Document Type: Conference Paper

References (27)

1. Holt PG. Immunoprophylaxis of atopy: light at the end of the tunnel? Immunol Today 1994; 15:484-9.
2. Holt PG, O'Keeffe PO, Holt BJ, Upham JW, Baron-Hay MJ, Suphioglu C, Knox B, Stewart GA, Thomas WR, Sly PD. T-cell "priming" against environmental allergens in human neonates: sequential deletion of food antigen specificities during infancy with concomitant expansion of responses to ubiquitous inhalant allergens. Ped Allergy Immunol 1995; 6:85-90.
3. Sedgwick JD, Holt PG. Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen inhalation. Cell Immunol 1985; 94:182-94.
4. McMenamin C, Holt PG. The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of IgE production. J Exp Med 1993; 178:889-99.
5. +-TH-2-dependent IgE responses to inhaled antigen in mice by antigen-specific γ/δ T-cells. Science 1994; 265:1859-1861.
6. McMenamin C, McKersey M, Kuhnlein P, Hunig T, Holt PG. γ/δ T-cells downregulate primary IgE responses in rats to inhaled soluble protein antigens. J Immunol 1995; 154:4390-94.
7. Thomas WR, Cooper D, Holt PG. Immunity at body surfaces. The Immunologist 1995; 3:130-132.
8. Friedman A, Weiner HL. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Science, USA 1994; 91:6688-92.
9. Strobel S, Ferguson A. Immune responses to fed protein antigens in mice. 3. Systemic tolerance or priming is related to age at which antigen is first encountered. Pediatr Res 1984; 18:588-94.
10. Mariani F, Price JF, Kemeny DM. The IgG subclass antibody response to an inhalant antigen (Dermatophagoides pteronyssinus) during the first year of life: evidence for early stimulation of the immune system following natural exposure. Clin Exp Allergy 1992; 22:29-33.
11. Hattevig G, Kjellman B, Bjerkstén B. Appearance IgE antibodies to ingested and inhaled allergens during the first 12 years of life in atopic and non-atopic children. Ped Allergy Immunol 1993; 4:182-6.
12. Holt PG. Primary allergic sensitisation to environmental antigens: perinatal T-cell priming as a determinant of responder phentotype in adulthood. J Exp Med 1996; 183:1297-1301.
13. Yabuhara A, Macaubas C, Prescott SL, Venaille T, Holt BJ, Habre W, Sly PD, Holt PG. Th-2-polarised immunological memory to inhalant allergens in atopics is established during infancy and early childhood. Clin Exp Allergy Submitted:
14. Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationshiip: is successful pregnancy a Th2 phenomenon? Immunol Today 1993; 14:353-56.
15. Krishnan L, Guilbert LJ, Wegmann TG, Belosevic M, Mosmann TR. T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resportions. J Immunol 1996; 156:653-62.
16. Chen N, Gao Q, Field EH. Expansion of memory Th2 cells over Th1 cells in neonatal primed mice. Transplantation 1995; 60:1187-93.
17. Holt PG. Postnatal maturation of immune competence during infancy and early childhood. Pediatr Allergy Immunol 1995; 6:59-70.
18. Holt PG, Clough JB, Holt BJ, Baron-Hay MJ, Rose AH, Robinson BWS, Thomas WR. Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence. Clin Exp Allergy 1992; 22:1093-9.
19. Warner JA, Miles EA, Jones AC, Quint DJ, Colwell BM, Warner JO. Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema? Clin Exp Allergy 1994; 24:423-30.
20. Tang MLK, Kemp AS, Thorburn J, Hill DJ. Reduced interferon-γ secretion in neonates and subsequent atopy. Lancet 1994; 344:983-86.
21. Rinas U, Horneff G, Wahn V. Interferon-γ production by cord-blood mononuclear cells is reduced in newborns with a family history of atopic disease and is independent from cord blood IgE-levels. Pediatr Allergy Immunol 1993; 4:60-4.
22. Singh RR, Hahn BH, Sercarz EE. Neonatal peptide exposure can prime T cells, and upon subsequent immunization induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. J Exp Med 1996; 183:1613-1622.
23. Ridge JP, Fuchs EJ, Matzinger P. Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 1996; 271:1723-1726.
24. Schon-Hegrad MA, Oliver J, McMenamin PG, Holt PG. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J Exp Med 1991; 173:1345-56.
25. Holt PG, Haining S, Nelson DJ, Sedgwick JD. Origin and steady-state turnover of class II MHC-bearing Dendritic Cells in the epithelium of the conducting airways. J Immunol 1994; 153:256-61.
26. Nelson DJ, McMenamin C, McWilliam AS, Brenan M, Holt PG. Development of the airway intraepithelial Dendritic Cell network in the rat from class II MHC (Ia) negative precursors: differential regulation of la expression at different levels of the respiratory tract. J Exp Med 1994; 179:203-12.
27. Nelson DJ, Holt PG. Defective regional immunity in the respiratory tract of neonates is attributable to hyporesponsiveness of local Dendritic Cells to activation signals. J Immunol 1995; 155:3517-3524.