Bioactivation of lapachol responsible for DNA scission by NADPH-cytochrome P450 reductase

Environmental Toxicology and Pharmacology

Volumn 3, Issue 4, 1997, Pages 245-250

  Kumagai, Yoshito ^a   Tsurutani, Yoshimi ^a   Shinyashiki, Masaru ^a   Homma Takeda, Shino ^a   Nakai, Yumi ^b   Yoshikawa, Toshikazu ^c   Shimojo, Nobuhiro ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Active oxygen; Bioactivation; DNA scission; Lapachol; NADPH cytochrome P450 reductase; Quinone reduction

Indexed keywords

LAPACHOL; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; LIVER MICROSOME; MALE; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030847714     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(97)00019-7     Document Type: Article

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