Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat

Neuroscience Letters

Volumn 231, Issue 3, 1997, Pages 135-138

  Smith, Douglas H ^a   Perri, Brian R ^a   Raghupathi, Ramesh ^a   Saatman, Kathryn E ^a   McIntosh, Tracy K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

2,3,5 Triphenyltetrazolium chloride; Brain trauma; Lesion volume; Memory; Neuroprotection; Remacemide hydrochloride

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; REMACEMIDE; SODIUM CHANNEL BLOCKING AGENT; TRIPHENYLTETRAZOLIUM;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INJURY; BRAIN PROTECTION; BRAIN SIZE; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETAMIDES; ANIMALS; BRAIN INJURIES; CEREBRAL CORTEX; MALE; MEMORY DISORDERS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0030847455     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00551-X     Document Type: Article

References (23)

1. Bannan, P.E., Graham, D.I., Lees, K.R. and McCulloch, J., Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat, Brain Res., 664 (1994) 271-275.
2. Bartus, R.T., Hayward, N.J., Elliott, P.J., Sawyer, S.D., Baker, K.L., Dean, R.L., Akiyama, A., Straub, J.A., Harbeson, S.L., Li, Z. and Powers, J., Calpain inhibitor AK295 protects neurons from focal brain ischemia: effects of postocclusion intraarterial administration, Stroke, 25 (1994) 2265-2270.
3. Bose, B., Jones, S.C., Lorig, R., Friel, H.T., Weinstein, M. and Little, J.R., Evolving focal cerebral ischemia in cats: spatial correlation of nuclear magnetic resonance imaging, cerebral blood flow, tetrazolium staining, and histopathology, Stroke, 19 (1988) 28-37.
4. Cole, D.J., Schell, R.M., Drummond, J.C., Pryzbelski, R.J. and Marcantonio, S., Focal cerebral ischemia in rats: effect of hemodilution with '-' cross-linked hemoglobin on brain injury and edema, Can. J. Neurol. Sci., 20 (1993) 30-36.
5. Dietrich, W.D., Alonso, O., Mordecai, R.B., Globus, Y.T. and Ginsberg, M.D., Post-traumatic brain hypothermia reduces histopathological damage following concussive brain injury in the rat, Acta Neuropathol. (Berlin), 87 (1994) 250-258.
6. Faden, A.I., Demediuk, P., Panter, S.S. and Vink, R., The role of excitatory amino acids and NMDA receptors in traumatic brain injury, Science, 244 (1989) 789-800.
7. Katayama, Y., Becker, D.P., Tamura, T. and Hovda, D.A., Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury, J. Neurosurg., 73 (1990) 889-900.
8. McIntosh, T.K., Vink, R., Noble, L., Yamakami, I., Fernyak, S. and Faden, A.I., Traumatic brain injury in the rat: characterization of a lateral fluid percussion model, Neuroscience, 28 (1989) 233-244.
9. Morris, R.G.M., Developments of a water maze procedure for studying spatial learning in the rat, J. Neurosci. Methods, 11 (1984) 47-60.
10. Nilsson, P., Hillered, L., Ponten, U. and Urgerstedt, V., Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats, J. Cerebral Blood Flow Metab., 10 (1990) 631-637.
11. Olney, J.W., Labruyere, J. and Price, M., Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs, Science, 244 (1989) 1360-1362.
12. Palmer, A.M., Marion, D.W., Botscheller, M.L., Swedlow, P.E., Styren, S.D. and DeKosky, S.T., Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model, J. Neurochem., 61 (1993) 2015-2024.
13. Palmer, G.C., Clark, B. and Hutchison, J.B., Antiepileptic and neuroprotective potential of remacemide hydrochloride, Drugs Future, 18 (1993) 1021-1042.
14. Palmer, G.C., Murray, R.J., Wilson, T.C.M., Eisman, M.S., Ray, R.K., Griffith, R.C., Napier, J.J., Fedorchuk, M., Stagnitto, M.L. and Garske, G.E., Biological profile of the metabolites and potential metabolites of the anticonvulsant remacemide, Epilepsy Res., 12 (1992) 9-20.
15. Park, C.K., Mendelow, A.D., Graham, D.I., McCulloch, J. and Teasdale, G.M., Correlation of triphenyltetrazolium chloride perfusion staining with conventional neurohistology in the detection of early brain ischaemia, Neuropathol. Appl. Neurobiol., 14 (1988) 289-298.
16. Perri, B., Murai, H., Smith, D.H., Sinson, G., Saatman, K.E., Bartus, R.T. and McIntosh, T.K., Metabolic quantification of lesion volume following experimental traumatic brain injury in the rat, J. Neurotrauma, 14 (1997) 15-22.
17. Rogawski, M.A., Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines, Trends Pharmacol. Sci., 14 (1993) 325-331.
18. Sharp, F., Jasper, P., Hall, J., Noble, L. and Sagar, S.M., MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex, Ann. Neurol., 30 (1991) 801-809.
19. Smith, D.H. and McIntosh, T.K., Traumatic brain injury and excitatory amino acids. In R.K. Narayan, J.E. Wilberger and J.T. Povlishock (Eds.), Neurotrauma, McGraw-Hill, New York, 1996, pp. 1445-1458.
20. Smith, D.H., Okiyama, K., Gennarelli, T.A. and McIntosh, T.K., Magnesium and ketamine attenuate cognitive dysfunction following experimental brain injury, Neurosci. Lett., 157 (1993) 211-214.
21. Smith, D.H., Okiyama, K., Thomas, M.J., Claussen, B. and McIntosh, T.K., Evaluation of memory dysfunction following experimental brain injury using the Morris water maze, J. Neurotrauma, 8 (1991) 259-269.
22. Toulmond, S., Serrano, A., Benavides, J. and Scatton, B., Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window, Brain Res., 620 (1993) 32-41.
23. Zuccarello, M., Lewis, A.I., Upputuri, S., Farmer, J.B. and Anderson, D.K., Effect of remacemide hydrochloride on subarachnoid hemorrhage-induced vasospasm in rabbits, J. Neurotrauma, 11 (1994) 691-698.