Human growth hormone antagonist (G120R) delivered by a murine yolk sac cell-derived mini-organ decreases the growth rate of mice

Stem Cells

Volumn 15, Issue 5, 1997, Pages 364-367

  Wei, Yanzhang ^a   Li, Jinhua ^a   Chen, Wen Y ^a   Wagner, Thomas E ^a  

^a OHIO UNIVERSITY   (United States)

Author keywords

G120R; Gene delivery; IGF 1; Mice; Mini organ; Yolk sac cell

Indexed keywords

HORMONE ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY GROWTH; CELL TRANSPLANTATION; CONTROLLED STUDY; GENE TARGETING; GROWTH RATE; IMPLANTATION; MOUSE; NONHUMAN; YOLK SAC;

ANIMALIA; MURINAE;

EID: 0030845832     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.150364     Document Type: Article

References (7)

1. Wei YZ, Quertermous T, Wagner TE. Directed endothelial differentiation of cultured embryonic yolk sac cells in vivo provides a novel cell-based system for gene therapy. STEM CELLS 1995;13:541-547.
2. Wei YZ, Li JH, Wagner TE. Long-term expression of human growth hormone (hGH) in mice containing allogeneic yolk sac cell derived neovascular implants expressing hGH. STEM CELLS 1996;14:232-238.
3. Chen NY, Chen WY, Bellush L et al. Effects of streptozotocin treatment in growth hormone (GH) and GH antagonist transgenic mice. Endocrinology 1995;136:660-667.
4. Chen WY, Chen NY, Yun J et al. In vitro and in vivo studies of antagonistic effects of human growth hormone analogs. J Biol Chem 1994;269:15892-15897.
5. Chen WY, White ME, Wagner TE et al. Functional antagonism between endogenous mouse growth-hormone (GH) and a GH analog results in dwarf transgenic mice. Endocrinology 1991;129:1402-1408.
6. G120R hGH does not antagonize GH in the rat, but has paradoxical agonist activity, probably via the prolactin receptors. Endocrinology 1996;137:447-454.
7. Murphy LJ, Tachibana K, Friesen HG. Stimulation of hepatic insulin-like growth factor-I gene expression by ovine prolactin: evidence for intrinsic somatogenic activity. Endocrinology 1988;122:2027-2033.