Treatment of neutropenic infection: Trends towards monotherapy?

Supportive Care in Cancer

Volumn 5, Issue 5, 1997, Pages 365-370

  Klastersky, J ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Antibiotics; Infection; Monotherapy; Neutropenia

Indexed keywords

AMIKACIN; AMPHOTERICIN B; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CARBENICILLIN; CEFALOTIN; CEFEPIME; CEFTAZIDIME; GENTAMICIN; IMIPENEM; MEROPENEM; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; TOBRAMYCIN;

AMBULATORY CARE; ANTIBIOTIC THERAPY; BACTEREMIA; CLINICAL TRIAL; GRAM NEGATIVE INFECTION; GRAM POSITIVE BACTERIUM; HOME CARE; HUMAN; INFECTION; MORTALITY; MYCOSIS; NEUTROPENIA; PRIORITY JOURNAL; REVIEW;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CAUSE OF DEATH; CLINICAL TRIALS; FEVER; HUMANS; NEUTROPENIA; RISK FACTORS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 0030845173     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005200050093     Document Type: Review

References (26)

1. Attal M, Schlaifer D, Rubie H, et al (1990) Prevention of gram-positive infections after bone marrow transplantation by systemic vancomycin: a prospective, randomized trial. J Clin Oncol 9:865-870
2. Awada A, Van der Auwera Ph, Meunier F, et al (1992) Streptococcal and enterococcal bacteremia in patients with cancer. Clin Infect Dis 15:33-48
3. Bodey GP, Buckley M, Sathe Y, et al (1966) Quantitative relationships between circulating leucocytes and infection in patients with acute leukemia. Ann Intern Med 64:328-340
4. Bodey GP, Middelman E, Umsawadi T, et al (1972) Infections in cancer patients. Results with gentamicin sulfate therapy. Cancer 29:1697-1701
5. Brown PK (1992) In: Bernard J, Bessi M, Binet JL (eds) Histoire illustrée de l'hématologie de l'antiquité à nos jours. Dacosta
6. Cometta A, Zinner S, De Bock R, et al (1995) Piperacillin-tazobactam plus amikacin versus ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. Antimicrob Agents Chemother 39:445-452
7. De Pauw BE, Derensinski SC, Feld R, et al (1994) Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer. Ann Intern Med 120:834-844
8. EORTC International Antimicrobial Therapy Cooperative Group (1987) Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. N Engl J Med 317:1692-1698
9. EORTC International Antimicrobial Therapy Cooperative Group (1991) Vancomycin added to empirical combination antibiotic therapy for fever in granulocytopenic cancer patients. J Infect Dis 163:951-958
10. EORTC International Antimicrobial Therapy Cooperative Group (1993) Efficacy and toxicity of single daily doses of amikacin and ceftriaxone versus multiple daily doses of amikacin and ceftazidime for infection in patients with cancer and granulocytopenia. Ann Intern Med 119:584-593
11. EORTC International Antimicrobial Therapy Cooperative Group (1995) Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. Antimicrob Agents Chemother 40:1108-1115
12. EORTC International Antimicrobial Therapy Project Group (1978) Three antibiotic regimens in treatment of infection in febrile granulocytopenic patients with cancer. J Infect Dis 137:14-29
13. Freifeld AG, Walsh T, Marshall D, et al (1995) Monotherapy for fever and neutropenia in cancer patients: a randomized comparison of ceftazidime versus imipenem. J Clin Oncol 13:165-176
14. Karp JE, Dick JD, Angelopulos C, et al (1986) Empiric use of vancomycin during prolonged treatment-induced granulocytopenia. Randomized double-blind, placebo-controlled clinical trial in patients with acute leukemia. Am J Med 81:237-242
15. Klastersky J, Daneau D, Swings G, Weerts D (1974) Antibacterial activity in serum and urine as a therapeutic guide in bacterial infections. J Infect Dis 129:187-193
16. Klastersky J, Glauser MP, Schimpff SC, et al (1986) Prospective randomized comparison of three antibiotic regimens of suspected bacteremic infection in febrile granulocytopenic patients. Antimicrob Agent Chemother 29:263-270
17. Lamy T, Michetlet C, Dauriac C et al (1993) Benefit of prophylaxis by intravenous systemic vancomycin in granulocytopeic patients: a prospective, randomized trial among 59 patients. Acta Hematol 90:109-113
18. McCabe WR, Jackson GG (1962) Gram negative bacteremia. II. Clinical, laboratory and therapeutic observations. Arch Intern Med 110:856-864
19. Pizzo PA, Harthorn JW, Hiemenz J, et al (1986) A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. N Engl J Med 315:552-558
20. Rossi C, Klastersky J (1996) Initial empirical antibiotic therapy for neutropenic fever: analysis of the causes of death. Support Care Cancer 4:207-212
21. Rubin M, Hathorn JW, Marshall D, et al (1988) Gram-positive infections and the use of vancomycin in 550 episodes of fever and neutropenia. Ann Intern Med 108:30-35
22. Schimpff S, Satterlee W, Young WM, et al (1971) Empirical therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. N Engl J Med 284:1061-1065
23. Schultz W (1992) In: Bernard J, Bessi M, Binet JL (eds) Histoire illustrée de l'hématologie de l'antiquité à nos jours. Dacosta
24. Sculier JP, Weerts D, Klastersky J (1984) Causes of death in febrile granulocytopenic cancer patients receiving empiric antibiotic therapy. Eur J Cancer Clin Oncol 20:55-60
25. Shenep J, Hughes WT, Robertson PK, et al (1988) Vancomycin ticarcillin and amikacin compared to ticarcillin-clavulanate and amikacin in the empirical treatment of febrile neutropenic children with cancer. N Engl J Med 319:1053-1058
26. Sickles EA, Greene WH, Wiernik PH (1975) Clinical presentation on infection in granulocytopenic patients. Arch Intern Med 135:715-719