Divergent subcellular locations of HTLV-I tax and Int-6: A contrast between in vitro protein-protein binding and intracellular protein colocalization

Journal of Biomedical Science

Volumn 4, Issue 5, 1997, Pages 229-234

  Neuveut, Christine ^a   Jin, Dong Yan ^a   Semmes, Oliver J ^a   Diella, Francesca ^b   Callahan, Robert ^b   Jeang, Kuan Teh ^a,c  

^a Natl Institutes Allerg Infect D   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

HTLV; Int 6; Tax; Transformation

Indexed keywords

HYBRID PROTEIN; VIRUS PROTEIN;

ARTICLE; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 0030844154     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/BF02253422     Document Type: Article

References (9)

1. Desbois C, Rousset R, Bantignies F, Jalinot P. Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-I Tax oncoprotein. Science 273:951-953;1996.
2. Diella F, Levi G, Callahan R. In press.
3. Marchetti A, Buttitta F, Miyazaki S, Gallahan D, Smith HG, Callahan R. Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia. J Virol 69:1932-1938;1995.
4. Semmes OJ, Jeang K-T. Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins. J Virol 66:7183-7192; 1992.
5. Semmes OJ, Jeang K-T. Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles. J Virol 70:6347-6357;1996.
6. Siomi H, Shida H, Nam SH, Nosaka T, Maki M, Hatanaka M. Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing. Cell 55:197-209;1988.
7. Slamon DJ, Boyle WJ, Keith DE, Press MF, Golde DW, Souza LM. Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I. J Virol 62:680-686; 1988.
8. Smith MR, Greene WC. Indentification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev 4:1875-1885;1990.
9. Smith MR, Greene WC. Characterization of a novel nuclear localization signal in the HTLV-I tax transactivator protein. Virology 187:316-320;1992.