Biotransformation and pharmacokinetics of prodrug 9-(β-D-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(β-D-1,3-dioxolan-4-yl)guanine in mice

Antiviral Research

Volumn 35, Issue 3, 1997, Pages 187-193

  Manouilov, Konstantine K ^a   Manouilova, Lidia S ^a   Boudinot, F Douglas ^a   Schinazi, Raymond F ^b   Chu, Chung K ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

Aminopurine dioxolane; Dioxolane guanine; Mice; Pharmacokinetics; Prodrug

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; ANTIVIRUS AGENT; DRUG METABOLITE; GUANINE DERIVATIVE; PRODRUG; PURINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; DRUG METABOLISM; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

2-AMINOPURINE; ADMINISTRATION, ORAL; ALLOPURINOL; ANIMALS; BIOTRANSFORMATION; BRAIN CHEMISTRY; DIOXOLANES; DRUG INTERACTIONS; FEMALE; GUANINE; GUANOSINE; INJECTIONS, INTRAVENOUS; LIVER; MICE; PRODRUGS; PURINES; XANTHINE OXIDASE;

ANIMALIA; HEPATITIS B VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030839771     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(97)00028-4     Document Type: Article

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