Cloning, characterization, and expression of a calcitonin receptor from guinea pig brain

Journal of Neurochemistry

Volumn 69, Issue 2, 1997, Pages 455-464

  Sarkar, Atom ^a   Dickerson, Ian M ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Calcitonin receptor; Cyclic AMP; Diencephalon; Inositol phosphate; Reverse transcription polymerase chain reaction; Seven transmembrane G protein coupled receptor

Indexed keywords

ALPHA CALCITONIN GENE RELATED PEPTIDE; AMYLIN; CALCITONIN; CALCITONIN RECEPTOR; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; SALCATONIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; DIENCEPHALON; GENE EXPRESSION; GUINEA PIG; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE DISTRIBUTION; XENOPUS;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0030838494     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69020455.x     Document Type: Article

References (30)

1. Albrandt K., Mull E., Brady E. M. G., Herich J., Moore C. X., and Beaumont K. (1993) Molecular cloning of two receptors from rat brain with high affinity for salmon calcitonin. FEBS Lett. 325, 225-232.
2. Albrandt K., Brady E. M. G., Moore C. X., Mull E., Sierzega M. E., and Beaumont K. (1995) Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene. Endocrinology 136, 5377-5384.
3. Azria M. (1989) The Calcitonins: Physiology and Pharmacology. Karger, Basel, Switzerland.
4. - channel activity in Xenopus oocytes expressing the cystic fibrosis gene. J. Biol. Chem. 266, 19142-19145.
5. 2+/inositol phosphate signaling pathways. Mol. Endocrinol. 6, 551-556.
6. Gomez-Saladin E., Wilson D. L., and Dickerson I. M. (1994) Isolation and in situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematode Caenorhabditis elegans. Cell. Mol. Neurobiol. 14, 9-25.
7. Gorn A. H., Lin H. Y., Yamin M., Auron P. E., Flannery M. R., Tapp D. R., Manning C. A., Lodish H. F., Krane S. M., and Goldring S. R. (1992) Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. J. Clin. Invest. 90, 1726-1735.
8. Gorn A. H., Rudolf S. M., Yamin M., Krane S. M., and Goldring S. R. (1993) The cloning of a human osteoclast calcitonin receptor from a giant cell tumor of bone (osteoclastoma). (Abstr.) J. Bone Miner. Res. 8, S385.
9. Houssami S., Findlay D. M., Brady C. L., Myers D. E., Martin T. J., and Sexton P. M. (1994) Isoforms of the rat calcitonin receptor: consequences for ligand binding and signal transduction. Endocrinology 135, 183-190.
10. Kuestner R. E., Elrod R. D., Grant F. J., Hagen F. S., Kuijper J. L., Matthewes S. L., O'Hara P. J., Sheppard P. O., Stroop S. D., Thompson D. L., Whitmore T. E., Findlay D. M., Houssami S., Sexton P. M., and Moore E. E. (1994) Cloning and characterization of an abundant subtype of the human calcitonin receptor. Mol. Pharmacol. 46, 246-255.
11. Lin H. Y., Harris T. L., Flannery M. S., Aruffo A., Kaji E. H., Gorn A., Kolakowski L. F. Jr., Lodish H. F., and Goldring S. R. (1991) Expression cloning of an adenylate cyclase-coupled calcitonin receptor. Science 254, 1022-1024.
12. Luebke A. E., Dahl G. P., Roos B. A., and Dickerson I. M. (1996) Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. Proc. Natl. Acad. Sci. USA 93, 3455-3460.
13. Moore E. E., Kuestner R. E., Stroop S. D., Grant F. J., Matthewes S. L., Brady C. L., Sexton P. M., and Findlay D. M. (1995) Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript. Mol. Endocrinol. 9, 959-968.
14. Nussenzveig D. R., Mathew S., and Gershengorn M. C. (1995) Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor. Endocrinology 136, 2047-2051.
15. Poyner D. R. (1992) Calcitonin gene-related peptide: multiple actions, multiple receptors. Pharmacol. Ther. 56, 23-51.
16. Prabhakaran M. (1990) The distribution of physical, chemical and conformational properties in signal and nascent peptides. Biochem. J. 269, 691-696.
17. Richter J. D. and Smith L. D. (1984) Stimulation of Xenopus oocyte protein synthesis by microinjected adenovirus RNA. Proc. Natl. Acad. Sci. USA 79, 3789-3793.
18. Sambrook J., Fritsch E. F., and Maniatis T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
19. Seuwen K., Lagarde A., and Pouyssegur J. (1988) Deregulation of hamster fibroblast proliferation by mutated ras oncogene is not mediated by constitutive activation of phosphoinositide-specific phospholipase C. EMBO J. 7, 161-168.
20. Sexton P. M., Houssami S., Hilton J. M., O'keeffe L. M., Center R. J., Gillespie M. T., Darcy P., and Findlay D. M. (1993) Identification of brain isoforms of the rat calcitonin receptor. Mol. Endocrinol. 7, 815-821.
21. Sexton P. M., Houssami S., Brady C. L., Myers D. E., and Findlay D. M. (1994) Amylin is an agonist of the renal porcine calcitonin receptor. Endocrinology 134, 2103-2107.
22. Shyu J.-F., Inoue D., Baron R., and Horne W. C. (1996) The deletion of 14 amino acids in the seventh transmembrane domain of a naturally occurring calcitonin receptor isoform alters ligand binding and selectively abolishes coupling to phospholipase C. J. Biol. Chem. 271, 31127-31134.
23. Uezono Y., Bradley J., Min C., McCarty N. A., Quick M., Riordan J. R., Chavkin C., Zinn K., Lester A., and Davidson N. (1993) Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors Channels 1, 233-241.
24. von Heijne G. (1983) Patterns of amino acids near signal-sequence cleavage sites. Eur. J. Biochem. 133, 17-21.
25. Warshawsky H., Goltzman D., Rouleau M. F., and Bergeron J. J. M. (1980) Direct in vivo demonstration by radioautography of specific binding sites for calcitonin in skeletal and renal tissues of the rat. J. Cell Biol. 85, 682-694.
26. Wong Y. H., Federman A., Pace A. M., Zachary I., Evans T., Pouyssegur J., and Bourne H. R. (1991) Mutant α subunits of Gi2 inhibit cyclic AMP accumulation. Nature 351, 63-65.
27. Yamin M., Flannery M. R., Tapp D. R., Gorn A. H., Krane S. M., and Goldring S. R. (1993) Analysis of a unique murine brain calcitonin receptor (CTR) cDNA and preliminary characterization of the murine CTR gene; evidence for the existence of functionally distinct isoforms of the CTR. (Abstr.) J. Bone Miner. Res. 8, S129.
28. Yamin M., Gorn A. H., Flannery M. R., Jenkins N. A., Gilbert D. J., Copeland N. G., Tapp D. R., Krane S. M., and Goldring S. R. (1994) Cloning and characterization of a mouse brain calcitonin receptor complimentary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology 135, 2635-2643.
29. Zaidi M., Moonga B. S., Bevis P. J. R., Alam A. S. M. T., Legon S., Wimalawansa S., MacIntyre I., and Breimer L. H. (1991) Expression and function of the calcitonin gene products. Vitam. Horm. 46, 87-164.
30. Zolnierowicz S., Cron P., Solinas-Toldo S., Fries R., Lin H. Y., and Hemmings B. A. (1994) Isolation, characterization, and chromosomal localization of the porcine calcitonin receptor gene. Identification of two variants of the receptor generated by alternative splicing. J. Biol. Chem. 269, 19530-19538.