Virulence-associated genes as markers of strain diversity in Helicobacter pylori infection

Journal of Gastroenterology and Hepatology (Australia)

Volumn 12, Issue 9-10, 1997, Pages 666-669

  Ito, Akira ^a   Fujioka, Toshio ^a   Kodama, Kaoru ^a   Nishizono, Akira ^a   Nasu, Masaru ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

CagA; Helicobacter pylori; PCR; Strain diversity; VacA

Indexed keywords

ADULT; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BIODIVERSITY; CONTROLLED STUDY; DUODENUM ULCER; FEMALE; GASTRITIS; GASTRODUODENAL ULCER; GENETIC POLYMORPHISM; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STOMACH ULCER; STRAIN DIFFERENCE;

EID: 0030834819     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1997.tb00532.x     Document Type: Article

References (21)

1. Warren JR. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; i: 1273.
2. Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; i: 1273-5.
3. Lee A, Fox J, Hazell S. Pathogenicity of Helicobaaer pylori: a perspective. Infect. Immunol. 1993; 61: 1601-10.
4. Langenberg W, Rauws EAJ, Widjojokusumo A, Tytgat GNJ, Zanen HC. Identification of Campylobacter pyloridis isolates by restriction endonuclease DNA analysis. J. Clin. Microbiol. 1986; 24: 414-17.
5. Majewski SIH, Goodwin CS. Restriction endonuclease analysis of the genome of Campylobacter pylori with a rapid extraction method: Evidence for considerable genomic variation. J. Infect. Dis. 1988; 157: 465-71.
6. Ito A, Fujioka T, Kubota T, Nasu M. Molecular typing of Helicobacter pylori: Differences in pathogenicity among diverse strains. J. Gastroenterol. 1996; .31: 1-5.
7. Covacci A, Censini S, Bugnoli M et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl Acad. Sci. USA 1993; 90: 5791-5.
8. Cover TL, Tummuru MKR, Cao P, Thompson SA, Blaser MJ. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J. Biol. Chem. 1994; 269: 10 566-73.
9. Phadnis SH, liver D, Janzon L, Normark S, Westblom TU. Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect. Immunol. 1994; 62: 1557-65.
10. Schmitt W, Haas R. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol. Microbiol. 1994; 12: 307-19.
11. Telford JL, Ghiara P, Dell'Orco M et al. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J. Exp. Med. 1994; 179: 1653-8.
12. Tummuru MKR, Cover TL, Blaser MJ. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production. Infect. Immunol. 1993; 61: 1799-809.
13. Wyle FA, Chang KJ. Do strains of Helicobacter pylori differ from one another? Eur. J. Gastroenterol. Hepatol. 1993; 5 (Suppl. 1): S9-15.
14. Figura N, Guglielmetti P, Rossolini A et al. Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J. Clin. Microbiol. 1989; 27: 225-6.
15. Dixon MF, Genta RM, Yardley JH et al. Classification and grading of gastritis; the updated Sydney system. Am. J. Surg. Pathol. 1996; 20: 1161-81.
16. Queiroz DMM, Mendes EN, Rocha GA. Indicator medium for isolation of Campylobacter pylori. J. Clin. Microbiol. 1987; 25: 2378-9.
17. Cover TL, Glupczynski Y, Lage AP et al. Serologic detection of infection with cagA: Helicobacter pylori strains. J. Clin. Microbiol. 1995; 33: 1496-500.
18. Lage AP, Godfroid E, Fauconnier A et al. Diagnosis of Helicobacter pylori infection by PCR: Comparison with other invasive techniques and detection of cagA gene in gastric biopsy specimens. J. Clin. Microbiol. 1995; 33: 2752-6.
19. Atherton JC, Cao P, Peek RM Jr, Tummuru MKR, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori: association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 1995; 270: 17 771-7.
20. Leunk RD, Johnson PT, David BC, Kraft WG, Morgan DR. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J. Med. Microbiol. 1988; 26: 93-9.
21. Xiang Z, Censini S, Bayeli PF et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect. Immunol. 1995; 63: 94-8.