Role of peripheral-type benzodiazepine receptors in steroidogenesis

Clinical Neuropharmacology

Volumn 20, Issue 6, 1997, Pages 473-481

  Gavish, Moshe ^a   Weizman, Ronit ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Benzodiazepines; Cell proliferation; Cell respiration; Peripheral type benzodiazepine receptors; PK 11195; Ro 5 4864; Steroidogenesis

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

ANIMAL TISSUE; BIOSYNTHESIS; CASTRATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HYPOPHYSECTOMY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REVIEW; STEROIDOGENESIS;

EID: 0030830910     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002826-199712000-00001     Document Type: Review

References (74)

1. Mohler H, Okada T. Benzodiazepine receptor: demonstration in the central nervous system. Science 1977;198:849-51.
2. 3H] diazepam binding. Proc Natl Acad Sci USA 1977;74:3805-9.
3. Tallman JF, Paul SM, Skolnick P, Gallager DW. Receptors for the age of anxiety: pharmacology of the benzodiazepines. Science 1980;207:274-81.
4. A receptors. Trends Pharmacol Sci 1995;16:162-7.
5. A receptor shows a ligand-gated receptor superfamily. Nature 1987;328:221-7.
6. Verma A, Snyder SH. Peripheral type benzodiazepine receptors. Annu Rev Pharmacol Toxicol 1989;29:307-22.
7. Davies LP, Huston V. Peripheral benzodiazepine binding sites in heart and their interaction with dipyridamole. Eur J Pharmacol 1981;73:209-11.
8. Fares F, Weizman A, Zlotogorski D, Gavish M. Ontogenetic development of peripheral benzodiazepine binding sites in rat brain, heart and lung. Brain Res 1987;408:381-4.
9. 3H]PK 11195 and autoradiographic localization. Arch Int Pharmacodyn Ther 1983;266:38-49.
10. De Souza EB, Anholt RRH, Murphy KMM, Snyder SH, Kuhar MJ. Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis. Endocrinology 1985;116:567-73.
11. Fares F, Bar-Ami S, Brandes JM, Gavish M. Gonadotropin- and estrogen-induced increase of peripheral-type benzodiazepine binding sites in the hypophyseal-genital axis of rats. Eur J Pharmacol 1987;133:97-102.
12. Katz Y, Amiri Z, Weizman A, Gavish M. Identification and distribution of peripheral benzodiazepine binding sites in male rat genital tract. Biochem Pharmacol 1990;40:817-20.
13. 3H]diazepam binding sites on rat blood platelets. Life Sci 1980;27:1881-8.
14. Gavish M, Weizman A, Karp L, Tyano S, Tanne Z. Decreased peripheral benzodiazepine binding sites in platelets of neuruleptic-treated schizophrenics. Eur J Pharmacol 1986;121:275-9.
15. Olson JMM, Ciliax BJ, Mancini WR, Young AB. Presence of peripheral-type benzodiazepine binding sites on human erythrocyte membranes. Eur J Pharmacol 1988;152:47-53.
16. Anholt RRH, Pedersen PL, De Souza EB, Snyder SH. The peripheral-type benzodiazepine receptor: localization to the mitochondrial outer membrane. J Biol Chem 1996;261:576-83.
17. O'Beirne GB, Woods MJ, Williams DC. Two subcellular locations for peripheral-type benzodiazepine acceptors in rat liver. Eur J Biochem 1990;188:131-8.
18. Basile AS, Klein DC, Skolnick P. Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site. Brain Res 1986;387:127-35.
19. 3H]PK 11195 to cerebral cortex and peripheral tissues of various species: species differences and heterogeneity in peripheral benzodiazepine binding sites. J Neurochem 1987;49:1407-14.
20. Award M, Gavish M. Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon. Life Sci 1991;49:1155-61.
21. McEnery MW, Snowman AM, Trifiletti RR, Snyder SH. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 1992;89:3170-4.
22. Papadopoulos V, Boujrad N, Ikonomovic MD, Ferrara P, Vidic B. Topography of the Leydig cell mitochondrial peripheral-type benzodiazepine receptor. Mol Cell Endocrinol 1994;104:R5-9.
23. Sprengel R, Werner P, Seeburg PH, et al. Molecular cloning and expression of cDNA encoding a peripheraltype benzodiazepine receptor. J Biol Chem 1989;264:20415-21.
24. Riond J, Mattei MG, Kaghad M, et al. Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. Eur J Biochem 1991;195:305-11.
25. Parola AL, Stump DG, Pepperl DJ, Krueger KE, Regan JW, Laird HE II. Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. J Biol Chem 1991;266:14082-7.
26. Garnier M, Dimchev AB, Boujrad N, Price JM, Musto NA, Papadopoulos V. In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Mol Pharmacol 1994;45:201-11.
27. Lin D, Chang YJ, Strauss JF III. Miller WL. The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. Genomics 1993;18:643-50.
28. Casalotti SO, Pelaia G, Yakovlev AG, Csikós T, Grayson DR, Krueger KE. Structure of the rat gene encoding the mitochondrial benzodiazepine receptor. Gene 1992;121:377-82.
29. Ritta MN, Campos MB, Calandra RS. Effect of GABA and benzodiazepines on testicular androgen production. Life Sci 1987;40:791-8.
30. Ritta MN, Calandra RS. Testicular interstitial cells as targets for peripheral benzodiazepines. Neuroendocrinology 1989;49:262-6.
31. Papadopoulos V, Mukhin AG, Costa E, Krueger KE. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem 1990;265:3772-9.
32. Mukhin AG, Papadopoulos V, Costa E, Krueger KE. Mitochondrial benzodiazepine receptors regulate steroid biosynthesis. Proc Natl Acad Sci USA 1989;86:9813-6.
33. Hirsch JD, Beyer CF, Malkowitz L, Beer B, Blume AJ. Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control. Mol Pharmacol 1989;35:157-63.
34. 2 consumption of neuroblastoma cells. Eur J Pharmacol 1989;161:197-202.
35. Wang JKT, Morgan JI, Spector S. Benzodiazepines that bind at peripheral sites inhibit cell proliferation. Proc Natl Acad Sci USA 1984;81:753-6.
36. Kunert-Radek J, Stepien H, Pawlikowski M. Inhibition of rat pituitary tumor cell proliferation by benzodiazepines in vitro. Neuroendocrinology 1994;59:92-6.
37. Pawlikowski M, Stepien H, Kunert-Radek J. Diazepam inhibits proliferation of the mouse spleen lymphocytes in vitro. Pol J Pharmacol Pharm 1986;38:167-70.
38. Pawlikowski M, Kunert-Radek J, Radek A, Stepien H. Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. Acta Neurol Scand 1988;77:231-3.
39. Ikezaki K, Black KL. Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine. Cancer Lett 1990;49:115-20.
40. Katz Y, Eitan A, Gavish M. Increase in peripheral benzodiazepine binding sites in colonic adenocarcinoma. Oncology 1990;47:139-42.
41. Katz Y, Ben-Baruch G, Kloog Y, Menczer J, Gavish M. Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries. Clin Sci 1990;78:155-8.
42. 14C]-deoxyglucose metabolism and peripheral benzodiazepine receptor binding in rat C6 glioma. Neurology 1988;38:1255-62.
43. Batra S, Alenfall J. Characterization of peripheral benzodiazepine receptors in rat prostatic adenocarcinoma. Prostate 1994;24:269-78.
44. Bar-Ami S, Fares F, Gavish M. Effect of hypophysectomy and hormone treatment on the induction of peripheral-type benzodiazepine binding sites in female rat genital axis. Horm Metab Res 1989;21:106-7.
45. Braw RH, Tsafriri A. Effect of PMSG on follicular atresia in the immature rat ovary. J Reprod Fertil 1980;59:267-72.
46. Freedman D, Auersperg N. The effects of pregnant mare serum gonadotropin (PMSG) on rat ovarian granulosa cell proliferation in vitro. Cell Biol Int Rep 1985;9:1.
47. Rao MC, Midgley AR Jr, Richards JS. Hormonal regulation of ovarian cellular proliferation. Cell 1978;14:71-8.
48. Moore WT Jr, Ward DN. Pregnant mare serum gonadotropin: an in vitro biological characterization of the lutropin-follitropin dual activity. J Biol Chem 1980;255:6930-6.
49. Fares F, Bar-Ami S, Haj-Yehia Y, Gavish M. Hormonal regulation of peripheral benzodiazepine binding sites in female rat adrenal gland and kidney. J Recept Res 1989;9:143-57.
50. Fares F, Bar-Ami S, Brandes JM, Gavish M. Changes in the density of peripheral benzodiazepine binding sites in genital organs of the female rat during the oestrous cycle. J Reprod Fertil 1988;83:619-25.
51. Bar-Ami S, Fares F, Gavish M. Altered peripheral benzodiazepine receptor density in human granulosalutein cells in relation to follicular maturity. Mol Cell Endocrinol 1991;82:285-91.
52. Barnea ER, Fares F, Gavish M. Modulatory action of benzodiazepines on human term placental steroidogenesis in vitro. Mol Cell Endocrinol 1989;64:155-9.
53. Gavish M, Bar-Ami S, Weizman R. The endocrine system and mitochondrial benzodiazepine receptors. Mol Cell Endocrinol 1992;88:1-13.
54. Mercer KA, Weizman R, Gavish M. Ontogenesis of peripheral benzodiazepine receptors: demonstration of selective up-regulation in rat testis as a function of maturation. J Recept Res 1992;12:413-25.
55. Anholt RRH, De Souza EB, Kuhar MJ, Snyder SH. Depletion of peripheral-type benzodiazepine receptors after hypophysectomy in rat adrenal gland and testis. Eur J Pharmacol 1985;110:41-6.
56. Arguelles AE, Rosner J. Diazepam and plasma testosterone levels [Letter]. Lancet 1975;2:607.
57. Gavish M, Okun F, Weizman A, Youdim MBH. Modulation of peripheral benzodiazepine binding sites following chronic estradiol treatment. Eur J Pharmacol 1986;127:147-51.
58. Murad F, Haynes RC Jr. Androgens. In: Gilman AG, Goodman LS, Rall TW, Murad F, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan; 1985:1440-58.
59. Amiri Z, Weizman R, Katz Y, et al. Testosterone and cyproterone acetate modulate peripheral but not central benzodiazepine receptors in rats. Brain Res 1991;553:155-8.
60. Poyet P, Labrie F. Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megastrol acetate. Mol Cell Endocrinol 1985;42:283-8.
61. Weizman A, Amiri Z, Katz Y, Snyder SH, Gavish M. Testosterone prevents castration-induced reduction in peripheral benzodiazepine receptors in Cowper's gland and adrenal. Brain Res 1992;572:72-5.
62. Gavish M, Weizman A, Youdim MBH, Okun F. Regulation of central and peripheral benzodiazepine receptors in progesterone-treated rats. Brain Res 1987;409:386-90.
63. Gavish M, Weizman A, Okun F, Youdim MBH. Modulatory effects of thyroxine treatment on central and peripheral benzodiazenbine receptors in the rat. J Neurochem 1986;47:1106-10.
64. Marc V, Morselli PL. Effect of diazepam on plasma corticosterone levels in the rat. J Pharm Pharmacol 1969;21:784-6.
65. Krueger KE, Papadopoulos V. Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J Biol Chem 1990;265:15015-22.
66. Gamier M, Boujrad N, Oke BO, et al. Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: action via peripheral-type benzodiazepine receptor and independent mechanisms. Endocrinology 1993;132:444-58.
67. Guarneri P, Papadopoulos V, Pan B, Costa E. Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'chlorodiazepam. Proc Natl Acad Sci USA 1992;89:5118-22.
68. Papadopoulos V. Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev 1993;14:222-10.
69. Deutsch SI, Mastropaolo J, Hitri A. GABA-active steroids: endogenous modulators of GABA-gated chloride ion conductance. Clin Neuropharmacol 1992;15:325-64.
70. Stocco DM, Clark BJ. Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 1996;17:221-44.
71. Weizman R, Gavish M. Molecular cellular and behavioral aspects of peripheral-type benzodiazepine receptors. Clin Neuropharmacol 1993;16:401-17.
72. Weizman R, Tanne Z, Granek M, et al. Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients. Eur J Pharmacol 1987;138:289-92.
73. Weizman R, Laor N, Karp L, et al. Alteration of platelet benzodiazepine receptors by stress of war. Am J Psychiatry 1994;151:766-7.
74. Gavish M, Laor N, Bidder M. Altered platelet peripheral-type benzodiazepine receptor in posttraumatic stress disorder. Neuropsychopharmacology 1996;14:181-6.