Interaction of the Rb tumor suppressor protein with the c-fos promoter in c-fos transfected cells overexpressing c-fos and Rb

Anticancer Research

Volumn 17, Issue 5 A, 1997, Pages 3265-3272

  Pai, Suresh R ^a,b   Bird, R Curtis ^a  

^a AUBURN UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

c fos; Cell cycle; HeLa cells; Overexpression; Promoter; Retinoblastoma gene; Transcription; Tumor suppressor

Indexed keywords

MONOCLONAL ANTIBODY; RETINOBLASTOMA PROTEIN;

ARTICLE; COMPLEX FORMATION; DNA PROTEIN COMPLEX; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; ONCOGENE C FOS; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE;

DEOXYRIBONUCLEOPROTEINS; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-FOS; RETINOBLASTOMA PROTEIN; TRANSFECTION;

EID: 0030828705     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Kruijer W, Cooper JA, Hunter T and Verma IM: Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature 312: 711-716, 1984.
2. Pai SR and Bird RC: Growth of HeLa S3 cells cotransfected with plasmids containing a c-fos gene under the control of the SV40 promoter complex, pRSVcat, and G418 resistance. Biochem Cell Biol 70: 316-323, 1992.
3. Bird RC, Kung T-Y, Wu G and Young-White RR: Variations in c-fos mRNA expression during serum induction and the synchronous cell cycle. Biochem Cell Biol 68: 858-862, 1990.
4. Tsuda T, Hamamori Y, Yamashita T, Fukumoto Y and Takai Y: Involvement of three intracellular messenger systems, protein kinase C, calcium ion and cyclic AMP, in the regulation of c-fos gene expression in Swiss 3T3 cells. FEBS Lett 208: 39-42, 1986.
5. Owen TA, Cosenza SC, Soprano RD and Soprano KJ: Time of c-fos and c-myc expression in human diploid fibroblasts stimulated to proliferate after prolonged periods of quiescence. J Biol Chem 262: 15111-15117, 1987.
6. Greenberg ME and Ziff EB: Stimulation of 3T3 cells induces transcription of the c-fos protooncogene. Nature 311: 433-438, 1984.
7. Muller R, Bravo R, Burkhardt J and Curran T: Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 312: 716-720, 1984.
8. Pai SR and Bird RC: c-fos expression is required during all phases ofthe cell cycle during exponential cell proliferation. Anticancer Res 14: 985-994, 1994.
9. Klein G: The approaching era of the tumor suppressor genes. Science 238: 1539-1545, 1987.
10. Weinberg RA: The molecular basis of retinoblastoma in genetic analysis of tumor suppression. Ciba foundation 142: 99-111, 1989.
11. Weinberg RA: Tumor suppressor genes. Science 254: 1138-1146, 1991.
12. Bookstein R, Shew IY, Chen BL, Scully B and Lee W-H: Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 247: 712-715, 1990.
13. Uzvolgyi E, Classon M, Henriksson M, Huang HJ, Szekely L, Lee WH, Klein G and Sunmegi J: Reintroduction of a normal retinoblastoma gene into retinoblastoma and osteosarcoma cells inhibits the replication associated function of SV40 large T antigen. Cell Growth Differ 2: 297-303, 1991.
14. Lee WH, Shew JY, Hong FD, Sery TW, Donoso LA, Young LJ, Bookstein R and Lee YP: The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 329: 642-645, 1987.
15. Wang NP, Chen P-L, Huang S, Donoso LA, Lee W-H and Lee EY-HP: DNA-binding activity of retinoblastoma protein is intrinsic to its carboxyl-terminal region. Cell Growth Differ 5: 233-239, 1990.
16. Mihara K, Cao X-R, Yen A, Chandler S, Driscoll B, Murphree AL, T'Ang A and Fung Y-KT: Cell cycle dependent regulation of phosphorylation of the human retinoblastoma gene product. Science 246: 1300-1303, 1989.
17. Pai SR and Bird RC: Overexpression of c-fos induces expression of the retinoblastoma tumor suppressor gene in transfected cells. Anticancer Res 14: 2501-2508, 1994.
18. Martelli F, Cenciarelli C, Santarelli G, Polikar B, Felsani A, Caruso M: MyoD induces retinoblastoma gene expression during myogenic differentiation. Oncogene 9: 3579-3590, 1994.
19. Chen P-L, Scully P, Shew J-Y, Wang IY-J and Lee W-H: Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58: 1193-1198, 1989.
20. Xu H-J, Hu S-X, Hashimoto T, Takahashi R and Benedict WF: The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells. Oncogene 4: 807-812, 1989.
21. Furukawa Y, DeCaprio JA, Freedman A, Kanakura Y, Nakamura M, Ernst TJ, Livingston DM and Griffin JD: Expression and state of phosphorylation of the retinoblastoma susceptibility gene in cycling and noncycling human hematopoietic cells. Proc Natl Acad Sci USA 87: 2770-2774, 1990.
22. Ludlow JW, Shon J, Pipas JM, Livingston DM and DeCaprio JA: The retinoblastoma susceptibility gene product undergoes cell cycle dependent dephosphorylation and binding to and release from SV40 large T. Cell 60: 387-396, 1990.
23. Stein GH, Beeson M and Gordon L: Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249: 666-669, 1990.
24. Goodrich DW, Wang NP, Qian Y, Lee EY-HP and Lee W-H: The retinoblastoma gene product regulates progression through the G1 phase of the cell-cycle. Cell 67: 293-302, 91.
25. Shiio Y, Sawada J, Yamamoto T and Inoue J: Activation of retinoblastoma gene expression by Bcl-3: implication tor muscle cell differentiation. Oncogene 12: 1837-1845, 1996.
26. Arber N, Sutler T, Miyake M, Kahn SM, Venkatraj VS, Sobrino A, Warburton D, Holt PR and Weinstein IB: Increased expression of cyclin D1 and the Rb tumor suppressor gene in c-K-ras transformed rat enterocytes. Oncogene 12: 1903-1908, 1996.
27. Kim S-J, Lee H-D, Robbins PD, Busam K, Sporn MB and Roberts AB: Regulation of transforming growth factor ß1 gene expression by the product of the retinoblastoma susceptibility gene. Proc Natl Acad Sci USA 88: 3052-3056, 1991.
28. Kim S-J, Onwuta US, Lee YI, Li R, Botchan MR and Robbins PD: The retinoblastoma gene product regulates Spl-Mediated transcription. Mol Cell Biol 12: 2455-2463, 1992.
29. Pietenpol JA, Stein RW, Moran E, Yaciuk P, Schlegel R, Lyons RM, Pittelkow MR, Munger K, Howley PM and Moses HL: TGF-ß1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell 61: 777-785, 1990.
30. Robbins PD, Horowitz JM and Mulligan RC: Negative regulation of human c-fos expression by the retinoblastoma gene product. Nature 346: 668-671, 1990.
31. Yen A and Varvayanis S: The ratio of retinoblastoma (RB) to fos and RB to myc expression during the cell cycle. Proc Soc Exp Biol Med 210: 205-21, 1995.
32. Zhu L, Zhu L, Xie E and Chang LS: Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol Cell Biol 15: 3552-3562, 1995.
33. Ikezu T, Okamoto T, Murayama Y, Okamoto T, Homma Y, Ogata E and Nishimoto I: Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product. J Biol Chem 269: 31955-31961, 1994.
34. Udvadia AJ, Rogers KT and Horowitz JM: A common set of nuclear factors bind to promoter elements regulated hy the retinoblastoma protein. Cell Growth Differ 3: 597-608, 1992.
35. Kim S-J, Wagner S, Liu F, O'Reilly MA, Robbins PD and Green MR: Retinoblastoma gene product activates expression of the human TGF-beta 2 gene through transcription factor ATF-2. Nature 358: 331-334, 1992.
36. Horowitz JM: Regulation of transcription hy the retinoblastoma protein. Genes Chromosom. Cancer 6: 124-131, 1993.
37. Batsche E, Lipp M and Cremisi C: Transcriptional repression and activation in the same cell type of the human c-MYC promoter by the retinoblastoma gene protein: antagonisation of both effects by SV40 T antigen. Oncogene 9: 2235-2243, 1994.
38. Gong Q, Huang Z and Wicks WD: Interaction of retinoblastoma gene product with transcription factors ATFa and ATF2. Arch Biochem Biophys 319: 445-450, 1995.
39. Dalton S: Cell cycle regulation ofthe human cdc2 gene. EMBO J 11: 1797-1804, 1992.
40. Ouellette MM, Chen J, Wright WE and Shay JW: Complexes containing the retinoblastoma gene product recognize different DNA motifs related to the E2F binding site. Oncogene 7: 1075-1081, 1992.
41. Kim S-J, Onwuta US, Lee YI, Li R, Botchan MR and Robbins PD: The retinoblastoma gene product regulates Spl-mediated transcription. Mol Cell Biol 12: 2455-2463, 1992.
42. Weintraub SJ, Prate, CA and Dean DC: Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358: 259-261, 1992.
43. Hamel PA, Gill RM, Phillips RA and Gallie BL: Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB 1 by the product of the RB 1 gene. Mol Cell Biol 12: 3431-3438, 1992.
44. Shan B, Chang CY, Jones D and Lee WH: The transcription factor E2F-1 mediates the autoregulation of RB gene expression. Mol Cell Biol 14: 299-309, 1994.
45. Shen WJ, Kim HS and Tsai SY: Stimulation of human insulin receptor gene expression by retinoblastoma gene product. J Biol Chem 270: 20525-20529, 1995.
46. Matin A and Hung MC: The retinoblastoma gene product, Rb, represses neu expression through two regions within the neu regulatory sequence. Oncogene 9: 1333-1339, 1994.
47. Park K, Choe J, Osifchin NE, Templelon DJ, Robbins PD and Kim SJ: The human retinoblastoma susceptibility gene promoter is positively autoregulated by its own product. J Biol Chem 269: 6083-6088, 1994.
48. Yamamoto M, Yoshida M, Ono K, Fujita T, Ohtani-Fujita N, Sakai T and Nikaido T: Effect of tumor suppressors on cell cycle-regulatory genes: RB suppresses p34cdc2 expression and normal pS3 suppresses cyclin A expression. Exp Cell Res 210: 94-101, 1994.
49. Adnane J, Shao Z and Robbins PD: The retinoblastoma susceptibility gene product represses transcription when directly bound to the promoter. J Biol Chem 270: 8837-8843, 1995.
50. Chen PL, Riley DJ, Chen-Kiang S and Lee WH: Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc Natl Acad Sci USA 93: 465-469, 1996.
51. Shan B, Zhu X, Chen P-L, Durfee T, Yang Y, Sharp D and Lee W-H: Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: Identification of a gene with properties of the transcription factor E2F Mol Cell Biol 12: 5620-5631, 1992.
52. Novak U, Paradiso L and Hamilton JA: Regulation of the urokinase gene by the retinoblastoma protein. DNA Cell Biol 13: 1063-1069, 1994.
53. Muller H, Lukas J, Schneider A, Warthoe P, Bartek J, Eilers M and Strauss M: Cyclin Dl expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci USA 91: 2945-2949, 1994.
54. Marhin WW, Hei YJ, Chen S, Jiang Z, Gallie BL, Phillips RA and Penn LZ: Loss of Rb and Myc activation co-operate to suppress cyclin Dl and contribute to transformation. Oncogene 12: 43-52, 1996.
55. Chen LI, Nishinaka T, Kwan K, Kitabayashi I, Yokoyama K, Fu YH, Grunwald S and Chiu R: The retinoblastoma gene product RB stimulates Spl-mediated transcription by liberating Spl from a negative regulator. Mol Cell Biol 14: 4380-4389, 1994.
56. Udvadia AJ, Rogers KT, Higgins PD, Murata Y, Martin KH, Humphrey PA and Horowitz JM: Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB co-expression. Proc Natl Acad Sci USA 90: 3265-3269, 1993.
57. Udvadia AJ, Templeton DJ and Horowitz JM: Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression. Proc Natl Acad Sci USA 92: 3953-3957, 1995.
58. Miller AD, Curran T and Verma IM: c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell-56: 51-60, 1984.
59. Ausubel FM, Brent R, Kingston RE, Moore DD, Smith JA, Seidman JG and Struhl K: Current Protocols in Molecular Biology, New York, Greene Publishing Assoc and Wiley-Interscience, 1989.
60. Pai SR and Bird RC: Quick and high-efficiency electroelution of nucleic acid fragments. Gene Analysis Techniques and Applications. 8: 214-216, 1991.
61. Goodwin GH: The analysis of sequence-specific DNA-binding proteins in cell extracts. In: Gel electrophoresis of nucleic acids a practical approach (Rickwood D and Hames BD, eds). Oxford, IRL press, pp 225-247, 1990.
62. Kim YW, Otterson GA, Kratzke RA, Coxon AB and Kaye FJ: Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. Mol Cell Biol 14: 7256-7264, 1994.
63. Janknecht R and Nordheim A: Regulation of the c-fos promoter by the ternary complex factor Sap-la and its coactivator CBP. Oncogene 12: 1961-1969, 1996.
64. Chen P-L, Riley DJ, Chen Y and Lee W-H: Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Gene and Develop 10: 2794-2804, 1996.
65. Wagner S and Green MR: A transcriptional tryst. Nature 352: 189-190, 1991.
66. Bird RC: The cyclin/cyclin-dependent kinase (cdk) complex: regulation of cell cycle progression and nuclear disassembly. In: Nuclear structure and gene expression (Bird RC, Stein GS, Lian JB and Stein JL, eds). San Diego, Academic Press, 1997, 145-174.