The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

Cell

Volumn 67, Issue 2, 1991, Pages 293-302

  Goodrich, David W ^a   Wang, Nan Ping ^a   Qian, Yue Wei ^a   Lee, Eva Y H P ^a   Lee, Wen Hwa ^a  

^a Center for Molecular Medicine Institute Biotechnology University Texas Health Science Center San Antonio ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN; PHOSPHOPROTEIN; RETINOBLASTOMA PROTEIN; VIRUS LARGE T ANTIGEN;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; HUMAN; HUMAN CELL; OSTEOSARCOMA; PRIORITY JOURNAL;

ANIMAL; ANTIGENS, VIRAL; APHIDICOLIN; BACULOVIRIDAE; BROMODEOXYURIDINE; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; G1 PHASE; HUMAN; HYDROXYUREA; INSECTS; MICROINJECTIONS; MICROSCOPY, FLUORESCENCE; NOCODAZOLE; OSTEOSARCOMA; PHOSPHORYLATION; RECOMBINANT PROTEINS; RETINOBLASTOMA PROTEIN; SIMIAN VIRUS 40; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0026058874     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(91)90181-W     Document Type: Article

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3. Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor
4. Cyclin A and the retinoblastoma gene product complex with a common transcription factor
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11. Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation
12. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
13. Purification of complexes of nuclear oncogene p53 with rat and Escherichia coil heat shock proteins: in vitro dissociation of the hsa70 and dnaK from murine p
14. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
15. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
16. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
17. Identification of germline and somatic mutations affecting the retinoblastoma gene
18. Large T antigens of many polyomaviruses are able to form complexes with the retinobalstoma protein
19. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
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25. An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments
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29. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations
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31. Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen
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34. Mutation and human cancer
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43. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
44. GI/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment
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46. Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes
47. G1 events and regulation of cell proliferation
48. Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas
49. C-terminal truncation of the RB protein leads to functional inactivation
50. The amino-terminal region of the adenovirus serotype 5 Ela protein performs two separate functions when expressed in primary baby rat kidney cells
51. A new SV40 mutant that encodes a small fragment of T antigen transforms established rat and mouse cells
52. The release of growth arrest by microinjection of adenovirus E1A DNA
53. Expression of the RB gene under the control of MuLV-LTR suppresses tumorigenicity of WERI-Rb-27 ratinoblastoma cells in immunodefective mice
54. Dissociation of Rb-binding and anchorage-independent growth from immortalization and tumorigenicity using SV40 mutants producing N-terminally truncated la
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60. Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpesinfected cells
61. Production of large numbers of mitotic mammalian cells by the use of the reversible microtubule inhibitor nocodazole