Effect of topically applied sulphur mustard on guinea pig liver

Journal of Applied Toxicology

Volumn 17, Issue 6, 1997, Pages 415-419

  Chauhan, R S ^a   Murty, L V R ^a  

^a Detence R and D Establishment   (India)

Author keywords

Electron microscopy; Guinea pig; Hepatotoxic; Liver; Steatosis; Sulphur mustard

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; MUSTARD GAS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GUINEA PIG; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; STEATOSIS; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CARCINOGENS; GUINEA PIGS; LIVER; MALE; MUSTARD GAS; ORGANELLES;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0030828569     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1263(199711/12)17:6<415::AID-JAT465>3.0.CO;2-D     Document Type: Article

References (16)

1. B. Papirmeister, A. J. Feister, S. I. Robinson and R. D. Ford, Medical Defence against Mustard Gas: Toxic Mechanisms and Pharmacological Implications, pp. 174-198. CRC Press, Boca Raton, FL (1991).
2. S. M. Somani and S. R. Babu, Toxicodynamics of sulphur mustard. Int. J. Clin. Pharmacol. Ther. Toxicol. 27, 419-435 (1989).
3. R. S. Chauhan, L V.R. Murthy and S. C Pant, Electron microscopic study of guinea pig skin exposed to sulphur mustard. Bull. Environ. Contam. Toxicol. 55, 50-57 (1995)
4. A. S. Warthin and C.V. Weller, The general pathology of mustard gas (dichloroethyl sulphide) poisoning. J. Lab. Clin. Med 4, 265-306 (1919).
5. J C Dacre and M Goldman. Toxicology and pharmacology of the chemical warfare agent sulfur mustard Pharmacol Rev 48 (2), 289-326 (1996)
6. 35S-sulphur mustard in rat and comparison with human blood in vitro. Xenobiotica 23, 537-561 (1993)
7. 34C sulphur mustard in rats after intravenous exposure Toxicol Appl Pharmacol. 125, 281-287 (1994)
8. A Fidder, G W H Moes, A G Scheffer, G P. Van der Schas, R A. Bann, L P A de Jong and H P. Benschop, Synthesis, characterization and quantitation of the major adducts formed between sulphur mustard and DNA of calf thymus and human blood Chem Res. Toxicol. 7, 199-204 (1994)
9. H L Meier C L Gross B Papiremeister and J E Daszkiewicz The use of human leukocytes as a model for studying the biochemical effects of chemical warfare (CW) agents In Proceedings of the 4th Annual Chemical Defense Bioscience Review. Aberdeen Proving Ground, Maryland, 30 May-1 June. US Army Medical Research Institute of Chemical Defense. Maryland (1984)
10. R S. Chauhan, K. Sugendran, L V R Murthy, K V. Ramana and S. Dasgupta, Sulphur mustard induced morphological changes in mice and human blood cells. Biomed. Lett. 53, 201-209 (1996)
11. H J. Karnovsky, A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J. Cell Biol. 27, 173A (1965).
12. I D. P. Watton, Microanalysis in Medical Biochemistry, pp. 108-119. J & A Churchill Ltd, London (1914)
13. J. Kao, The influence of metabolism on percutaneous absorption. In Percutaneous Absorption, 2nd Edn, ed. by R L Bronaugh and H I. Maibach, p. 259. Marcel Dekker, New York (1989).
14. G. J. Klain, K. E. Black and S. T. Omaye, Skin penetration and tissue distribution of radioactive butyl-2-chloroethyl sulphide in rat. J. Toxicol.-Cut. Ocul. Toxicol. 9, 505-509 (1989).
15. C. Davison, R. S. Rozman and P. K. Smith, Metabolism of bis-β-chloroethyl sulphide (sulphur mustard). Biochem. Pharmacol. 7, 65-74 (1961).
16. S. Andrejewski and J. Scianowski, Investigation on the toxic influence of sulphur yperite on selected internal rat organs and a histoautoradiographic assay of its distribution in internal organs damaged earlier with sulphur yperite. Patol. Polsk. 29, 51-60 (1978).