Metabolic investigations in humans by in vivo nuclear magnetic resonance;Explorations metaboliques chez l'homme par resonance magnetique nucleaire in vivo

Diabetes and Metabolism

Volumn 23, Issue 4, 1997, Pages 343-350

  Bloch, G ^b,c   Velho, G ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^c DIF   (France)

Author keywords

Humans; In vivo; Metabolic investigations; Nuclear magnetic resonance

Indexed keywords

GLUCOSE 6 PHOSPHATE; GLYCOGEN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DIABETES MELLITUS; DIAGNOSTIC IMAGING; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GLYCOGENOLYSIS; HUMAN; ISOTOPE LABELING; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE; PATHOPHYSIOLOGY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE;

BIOLOGICAL TRANSPORT; GLUCOSE; HUMANS; LIVER GLYCOGEN; MAGNETIC RESONANCE SPECTROSCOPY; MONITORING, PHYSIOLOGIC; MUSCLES; PHOSPHORYLATION;

EID: 0030827790     PISSN: 03381684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Price TB, Perseghin G, Duleba A et al. NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise. Proc Natl Acad Sci USA, 1996, 93, 5329-5334.
2. 13C nuclear magnetic resonance spectroscopy study. J Clin Invest, 1995, 95, 783-787.
3. Velho G, Petersen KF, Perseghin G et al. Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. J Clin Invest, 1996, 98, 1755-1761.
4. DeFronzo RA, Tobin JE, Andres R. Glucose clamp techniques : a method for quantifying insulin secretion and resistance. Am J Physiol, 1979, 237, E214-E223.
5. 13C-NMR measurements of muscle glycogen during low-intensity exercise. J Appl Physiol, 1991, 70, 1836-1844.
6. 13NMR. Neuromuscular Disorders, 1991, 1, 99-101.
7. 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magn Reson Med, 1992, 27, 13-20.
8. Shulman GI, Rothman DL, Jue T et al. Quantification of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by C nuclear magnetic resonance spectroscopy. N Engl J Med, 1990, 322, 223-228.
9. 31P Nuclear Magnetic Resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest, 1992, 89, 1069-1075.
10. 31P NMR measurement of glucose-6-phosphate in the rat muscle after exercise. Magn Reson Med, 1993, 30, 347-350.
11. Rothman DL, Magnusson I, Cline G et al. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA, 1995, 92, 983-987.
12. 13C NMR visibility of glucose in human skeletal muscle. Magn Reson Med, 1997, 37, 821-824.
13. Shulman RG, Bloch G, Rothman DL. In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis. Proc Natl Acad Sci USA, 1995, 92, 8535-8542.
14. Katz A, Nyomba BL, Bogardus C. No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia. Am J Physiol, 1988, 255, E942-E945.
15. Roussel R, Velho G, Carlier PG et al. In vivo NMR evidence for moderate glucose accumulation in human skeletal muscle during hyperglycemia. Am J Physiol, 1996, 271, E434-E438.
16. Roussel R, Velho G, Carlier PG et al. No accumulation of intracellular free glucose in human skeletal muscle during moderate hyperglycemic hyperinsulinemia. In : "Proc. Fifth Annual Meeting of the International Society for Magnetic Resonance in Medicine, Vancouver, 1997", 1344.
17. Jehenson P, Bloch G. Elimination of surface signals by a surfacespoiling magnetic field gradient. Theoretical optimization and application to human in vivo NMR spectroscopy. J Magn Reson, 1991, 94, 59-72.
18. 13C NMR. Science, 1991, 254, 573-576.
19. 13C2]glucose as substrate. Biochim Biophys Acta, 1991, 1095, 103-113.
20. 13C NMR measurements of liver glycogen in vivo. Magn Reson Med, 1994, 31, 583-588.
21. Shulman GI, Clinc G, Schumann WC et al. Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans. Am J Physiol, 1990, 259, E335-E341.
22. Roden M, Perseghin G, Petersen KF et al. The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest, 1996, 97, 642-648.
23. 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest, 1996, 97, 126-132.
24. 13C nuclear magnetic resonance study. J Clin Invest, 1992, 90, 1323-1327.
25. 13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus. J Clin Invest, 1994, 94, 2369-2376.