Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization

Differentiation

Volumn 61, Issue 5, 1997, Pages 321-331

  Nason Burchenal, Kathryn ^a   Maerz, Wolfgang ^a,b   Albanell, Juan ^a   Allopenna, Janet ^a   Martin, Patrick ^a,c   Moore, Malcolm A S ^a   Dmitrovsky, Ethan ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; PHORBOL 13 ACETATE 12 MYRISTATE; RETINOIC ACID; RETINOIC ACID RECEPTOR; TELOMERASE;

ARTICLE; CANCER RESISTANCE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL NUCLEUS INCLUSION BODY; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DOWN REGULATION; DRUG RESISTANCE; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR CLONING; MONOCYTE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DOMAIN; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ATRA;

EID: 0030826222     PISSN: 03014681     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-0436.1997.6150321.x     Document Type: Article

References (47)

1. Ahn M-J, Langenfeld J, Moasser MM, Rusch V, Dmitrovsky E (1995) Growth suppression of transformed human bronchial epithelial cells by all-trans-retinoic acid occurs through specific retinoid receptors. Oncogene 11:2357-2364
2. Ahn M-J, Nason-Burchenal K, Moasser MM, Dmitrovsky E (1995) Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RARα or PML. Oncogene 10:2307-2314
3. Albanell J, Han W, Mellado B, Gunawardane R, Scher HI, Dmitrovsky E, Moore MAS (1996) Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines. Cancer Res 56:1503-1508
4. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, Greider CW, Hurley CB (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 89:10114-10118
5. Bhatia M, Kirkland JB, Meckling-Gill KA (1994) M-CSF and 1,25 dihydroxy vitamin D3 synergize with 12-O-tetradecanoylphorbol-13-acetate to induce macrophage differentiation in acute promyelocytic leukemia NB4 cells. Leukemia 8:1744-1749
6. Blackburn EH (1991) Structure and function of telomeres. Nature 350:569-573
7. Borrow J, Goddard AD, Sheer D, Solomon E (1990) Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249:1577-1580
8. Castaigne S, Chomienne C, Daniel MT, Ballerini P, Berger R, Fenaux P, Degos L (1990) All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 76:1704-1709
9. Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent, A (1993) Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-α locus due to a variant t(11:17) translocation associated with acute promyelocytic leukaemia. EMBO J 12:1161-1167
10. Collins SJ, Robertson KA, Mueller L (1990) Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-α). Mol Cell Biol 10:2154-2163
11. Comic M, Delva L, Guidez, F, Balitrand N, Degos L, Chomienne C (1992) Induction of retinoic acid-binding protein in normal and malignant human myeloid cells by retinoic acid in acute promyelocytic leukemia patients. Cancer Res 52:3329-3334
12. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S (1992) Telomere shortening associated with chromosome instability in immortal cells which express telomerase activity. EMBO J 11:1921-1929
13. de Thé H, Chomienne C, Lanotte M, Degos L, Dejean A (1990) The t(15:17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor a gene to a novel transcribed locus. Nature 347:558-561
14. de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A (1991) The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66:675-684
15. Denizot F, Lang R (1986) Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Meth 89:271-277
16. Dermime S, Grignani F, Clerici M, Nervi C, Sozzi G, Talamo GP, Marchesi E, Formelli F, Parmiani G, Pelicci PG, Gambacorti-Passerini C (1993) Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the PML/RAR alpha protein. Blood 82:1573-1577
17. Duprez E, Lillehaug JR, Gaub MP, Lanotte M (1996) Differential changes of retinoid-X-receptor (RXRa) and its RARa and PML-RARa partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15:17) promyelocytic leukemia NB4 cells. Oncogene 12:2443-2450
18. Duprez E, Ruchaud S, Houge G, Martin-Thouvenin V, Valensi F, Kastner P, Berger R, Lanotte M (1992) A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features. Leukemia 6:1281-1287
19. Dyck JA, Maul GG, Miller WH Jr, Chen JD, Kakizuka A, Evans RM (1994) A novel macromolecular structure is a target of the promyelocyle-retinoic acid receptor oncoprotein. Cell 76:333-343
20. Grignani F, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Grignani F, Peschle C, Nicoletti I. Pelicci PG (1993) The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:423-431
21. Grignani F, Testa U, Fagioli M, Barberi T, Masciulli R, Mariani G, Peschle C, Pelicci PG (1995) Promyelocytic leukemia-specific PML-retinoic acid alpha receptor fusion protein interferes with erythroid differentiation of human erythroleukemia K562 cells. Cancer Res 55:440-443
22. Harley CB, Kim NW, Prowse KR, Weinrich SL, Hirsch KS, West MD, Bacchetti S, Hirte HW, Counter CM, Greider CW, Piatyszek MA, Wright WE, Shay JW (1994) Telomerase, cell immortality, and cancer. Cold Spring Harbor Symp Quant Biol 59:307-315
23. Holt S, Wright WE, Shay JW (1996) Regulation of telomerase activity in immortal cell lines. Mol Cell Biol 16:2932-2939
24. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu LJ, Wang ZY (1988) Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 72:567-572
25. Kakizuka A, Miller WH Jr, Umesono K, Warrell RJ Jr, Frankel SR, Murty VV, Dmitrovsky E, Evans RM (1991) Chromosomal translocation t(15:17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell 66:663-674
26. Kastner P, Perez A, Lutz Y, Rochette-Egly C, Gauh M-P, Durand B, Lanotte M, Berger R, Chambon P (1992) Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. EMBO J 11:629-642
27. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 226:2011-2015
28. Koken MHM, Puvion-Dutilleul F, Guillemin MC, Viron A, Linares-Cruz G, Stuurman N, de Jong L, Szostecki C, Calvo F, Chomienne C, Degos L, Puvion E, de Thé H (1994) The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J 13:1073-1083
29. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R (1991) NB4, a maturation inducible cell line with t(15:17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77:1080-1086
30. Larson R, Kondo K, Vardiman J, Butler A, Golomb H, Rowley J (1984) Evidence for a 15:17 translocation in every patient with acute promyelocytic leukemia. Am J Med 76:827-841
31. Longo L, Pandolfi PP, Biondi A, Rambaldi A, Mencarelli A, Lo Coco F, Diverio D, Pegoraro L, Avanzi G, Tabilio A, Zangrilli D, Alcalay M, Donti E, Grignani F, Pelicci PG (1990) Rearrangements and aberrant expression of the retinoic acid receptor α gene in acute promyelocytic leukemias. J Exp Med 172:1571-1575
32. Miller WH Jr, Kakizuka A, Frankel SR, Warrell RJ Jr, DeBlasio A, Levine K, Evans RM, Dmitrovsky E (1992) Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proc Natl Acad Sci USA 89:2694-2698
33. Moasser M, DeBlasio A, Dmitrovsky E (1994) Response and resistance to retinoic acid are mediated directly through the retinoic acid nuclear receptor gamma in human teratocarcinomas. Oncogene 9:833-840
34. Moasser MM, Reuter VE, Dmitrovsky E (1995) Over-expression of the retinoic acid receptor gamma directly induces terminal differention of human embryonal carcinoma cells. Oncogene 10:1537-1543
35. Moasser MM, Khoo K-S, Maerz WJ, Zelenetz A, Dmitrovsky E (1996) Derivation and characterization of retinoid resistant human embryonal carcinoma cells. Differentiation 60:251-257
36. Morosetti R, Grignani F, Liberatore C, Pelicci P, Schiller G, Kizaki M, Bartram C, Miller C, Koeffler H (1996) Infrequent alterations of the RARα gene in acute myelogenous leukemias, retinoic acid-resistant acute promyelocytic leukemias, myelodysplastic syndromes, and cell lines. Blood 10:4399-4403
37. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 65:55-63
38. Mu ZM, Chin KV, Liu JH, Lozano G, Chang KS (1994) PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol 14:6858-6867
39. Muindi J, Frankel SR, Miller WH Jr, Jakubowski A, Scheinberg DA, Young CW, Dmitrovsky E, Warrell RJ Jr (1992) Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia [published erratum appears in Blood 1992 Aug 1;80(3):855]. Blood 79:299-303
40. Nason-Burchenal K, Gandini D, Botto M, Allopenna J, Seale JRC, Cross NCP, Goldman JM, Dmitrovsky E, Pandolfi PP (1996) Interferon augments PML and PML/RARα expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans-retinoic acid to induce maturation of a retinoid resistant promyelocytic cell line. Blood 88:3926-3936
41. Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ (1996) The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood 87:882-886
42. Rousselot P, Hardas B, Patel A, Guidez F, Gäken J, Castaigne S, Dejean A, de Thé H, Degos L, Farzaneh F, Chomienne C (1994) The PML-RAR alpha gene product of the t(15:17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells. Oncogene 9:545-551
43. Ruchaud S, Duprez E, Gendron MC, Houge G, Genieser HG, Jastorff B, Doskeland SO, Lanotte M (1994) Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line. Proc Natl Acad Sci USA 91:8428-8432
44. Sharma HW, Sokoloski JA, Perez JR, Maltese JY, Sartorelli AC, Stein CA, Nichols G, Khaled Z, Telang NT, Narayanan R (1995) Differentiation of immortal cells inhibits telomerase activity. Proc Natl Acad Sci USA 92:12343-12346
45. Warrell RP Jr, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A, Jakubowski A, Gabrilove J, Gordon MS, Dmitrovsky E (1991) Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans retinoic acid). N Engl J Med 324:1385-1393
46. Weis K, Rambaud S, Lavau C, Jansen J, Carvalho T, Carmo-Fonseca M, Lamond A, Dejean A (1994) Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. Cell 76:345-356
47. Zhang W, Piatyszek MA, Kobayashi T, Estey E, Andreeff M, Deisseroth AB, Wright WE, Shay JW (1996) Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. Clin Cancer Res 2:799-803